A Cognitive Grammatical Study of Possessive Constructions in Orwell’s ‘A Clergyman’s Daughter’

This paper focuses on investigating the syntax and semantics of possessive constructions in A Clergyman’s Daughter at the phrasal level, within the framework of cognitive grammar using Heine’s (1997) model of possessives. The study aims at analyzing the various semantic relations in possessive constructions from a cognitive grammar perspective, and showing that possession does have a privileged status in the semantics of other concepts. This, however, proves the fallacy of the traditional view. It also shows that there is a natural and systematic relationship between possessive constructions and cognitive constructional schemas that give rise to them through conceptual transfer, and are motivated by experiential gestalt. No model alone can account for all semantic relations expressed through prototypical possessive. After analyzing possessive structures using Heine’s (1997) classification of possessives, there remains a group of other semantic relations that Heine (1997) could not have given a label; they are uncategorized. For underlying grammatical structures of these possessives, Lakoff and Johnson’s (1980) model is used, which propose that aspects of the experiential gestalt motivate the wider use of too complex possessive constructions

The Tourism Demarketing Mix: Working to Reduce Revisits to Egyptian Nature Reserves

This study tests the impact of the tourism demarketing mix (product, price, place, promotion) on tourists’ intention to reduce revisits to nature reserves in Egypt. In particular, this work focuses on the moderating role of switching cost. Data were collected from 401 tourists of the Wadi Degla and Petrified Forest nature reserves in Egypt. Path analysis is employed to test the research hypotheses using WarpPLS 6. Findings confirm that the tourism demarketing mix significantly affects tourists’ perception and intention to reduce revisits to the nature reserves. Lower switching cost partially enhanced the relationship between the tourism demarketing mix and tourists’ intention to reduce revisits. Regarding implications, managers can use findings from this study to design marketing plans that contribute to sustainable stewardship of destinations and protect nature reserves. Limitations and conclusions were also provided

Prevalence of Being Obese, Overweight, and Underweight Among Jordanian Children and Adolescents Based on International Growth Standards

Objectives: The rise of obesity and other nutrition-related conditions among children and adolescents is a global challenge, particularly in the Middle East. This study aimed to determine the prevalence of being underweight, overweight, and obese among Jordanian children and adolescents using the body mass index (BMI) percentiles of the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) standards. Methods: This retrospective cross-sectional/longitudinal study analyzed 58,474 (42.6% males; 57.4% females) height, weight, and BMI-for-age records from 31508 healthy Jordanian children and adolescents aged 2–19 years. The data were retrieved from the Ministry of Health’s nationwide electronic database (2017–2023) and assessed using the CDC and WHO growth standards. Logistic regression was performed to assess the variables associated with overweight/obese status. Results: The prevalence of being underweight, overweight, and obese varied by the reference used, as more cases of being obese and underweight were reported when applying the CDC standards. The regression models showed the males had significantly lower odds of being overweight and obese than the females. Increased age was associated with higher odds of being overweight and obese, with annual increases observed across all age groups. Conclusions: Using the WHO and CDC standards, the prevalence of being underweight was higher in the males aged 6 years and older, while being overweight and obese was more prevalent in the females. The observed annual increase in the prevalence of being overweight and obese underscores the need for targeted strategies. Growth references tailored to regional profiles may improve national nutrition policies for Jordanian children and adolescents

Evaluating the validity of international standards of Height, weight, and body mass index on Jordanian children and adolescents

Background: the variations in a child's overall body shape and figure among different countries are attributable to differences in genetics, environmental factors, and the interaction between these elements. This study aims to evaluate the validity, reliability, and appropriateness of ap-plying the international growth standards to Jordanian children and adolescents aged 2-19 years old. Methods: 65828 Jordanian children and adolescents (43% males; 57% females) aged 2-19 years old were selected from the Hakeem Program database and various private schools across Jordan. Height-for-age, weight-for-age, and body mass index (BMI)-for-age were analyzed comparatively for Jordanian children and adolescents against the international growth standards. The z-score for each record was computed based on international equations. Results: Mean z-scores for height-for-age, weight-for-age, and BMI-for-age for both genders showed significant deviation from the international standards across most age intervals. It was found that in most age groups, Jordanian children and adolescents were shorter and lighter than the CDC and WHO standards, except for females at ages ≥ 16 years which were heavier with higher BMI-for-age values than CDC standards based on weight-for-age and BMI-for-age equations. Moreover, Jordanian males at ages ≥ 12 years had lower BMI-for-age values than the CDC standards. Conclusions: Jordanian children and adolescents showed significant deviations in their measurements from international standards and growth reference values. The development of a population-specific growth chart is highly recommended to enhance the accuracy of evaluating children’s and adolescents' wellness

Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats

Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicates that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-1 (GLT-1) and cystine/glutamate antiporter (xCT) but not the glutamate/aspartate transporter (GLAST). Additionally, metabotropic glutamate receptors (mGluRs) expression was affected following exposure to EtOH or NIC. However, little is known about the effects of EtOH and NIC co-consumption on GLT-1, xCT, GLAST, and mGluR1 expression. In this study, peri-adolescent female alcohol preferring (P) rats were given binge-like access to water, sucrose (SUC), SUC-NIC, EtOH, or EtOH-NIC for four weeks. The present study determined the effects of these reinforcers on GLT-1, xCT, GLAST, and mGluR1 expression in the nucleus accumbens (NAc), hippocampus (HIP) and prefrontal cortex (PFC). GLT-1 and xCT expression were decreased in the NAc following both SUC-NIC and EtOH-NIC. In addition, only xCT expression was downregulated in the HIP in both of these latter groups. Also, glutathione peroxidase (GPx) activity in the HIP was reduced following SUC, SUC-NIC, EtOH, and EtOH-NIC consumption. Similar to previous work, GLAST expression was not altered in any brain region by any of the reinforcers. However, mGluR1 expression was increased in the NAc in the SUC-NIC, EtOH, and EtOH-NIC groups. These results indicate that peri-adolescent binge-like drinking of EtOH or SUC with or without NIC may exert differential effects on astroglial glutamate transporters and receptors. Our data further parallel some of the previous findings observed in adult rats

Acceptance of Flu Vaccine among Parents of Diabetic Children in Jordan

Abstract: There is a critical need to understand vaccine decision-making in high-risk groups. This study explored flu vaccine acceptance among Jordanian parents of diabetic children. Employing a cross-sectional approach, 405 parents from multiple healthcare centers across Jordan were recruited through stratified sampling, ensuring a broad representation of socioeconomic backgrounds. A structured questionnaire, distributed both in-person and online, evaluated their knowledge, attitudes, and acceptance of the flu vaccine for their diabetic children. The results indicated that only 6.4% of the study sample reported vaccinating their children against the flu annually, and only 23% are planning to vaccinate their children this year. A multinomial logistic regression analysis revealed notable variability in responses. Specifically, parents with a positive attitude towards the flu vaccine and those with older children had less odds to reject the vaccine (OR = 0.589, 95% CI (0.518–0.670), p &lt; 0.001 and OR = 0.846, 95% CI (0.736–0.974), p = 0.02, respectively). Conversely, prevalent misconceptions regarding vaccine safety and efficacy emerged as significant barriers to acceptance.Our findings advocate for targeted educational programs that directly address and debunk these specific misconceptions. Additionally, strengthened healthcare communication to provide clear, consistent information about the flu vaccine’s safety and benefits is vital to help enhance vaccine uptake among this vulnerable population, emphasizing the need to address specific concerns and misinformation directly.</div

Novel microfluidic development of pH-responsive hybrid liposomes : in vitro and in vivo assessment for enhanced wound healing

Wound healing is a complex biological process crucial for tissue repair, especially in chronic wounds where healing is impaired. Liposomes have emerged as promising vehicles for delivering therapeutics to facilitate wound repair. Liposomes have been explored as effective carriers for therapeutic agents. However, traditional methods of liposome preparation face significant challenges, particularly in achieving consistent stability and precise control over drug encapsulation and release. This study addresses these challenges by pioneering the development of Hybrid Liposomes (HLPs) using microfluidic technology, which provides more controlled characteristics through precisely managed formulation parameters. Notably, the formation of Polydopamine (PDA) polymer within HLPs facilitates pH-responsive drug release, making them well-suited for acidic wound environments. Furthermore, surface modification with Folic Acid (FA) enhances cellular interaction with the HLPs. In vitro and in vivo studies demonstrate the efficacy of HLPs loaded with Hyaluronic Acid (HA) or Phenytoin (PHT) in promoting wound healing. Microfluidics optimizes the stability of HLPs over 90 days, underscoring their potential as a potent, antibiotic-free drug delivery system. In conclusion, this research advances the understanding of microfluidic optimization for HLPs, offering cutting-edge drug delivery systems. The transformative potential of targeted HLPs through microfluidics holds promise for revolutionizing wound healing and inspires optimism for effective therapeutic interventions

The Development of Standardized National Head Circumference Growth Charts for Jordanian Children Aged 0-5 Years:A longitudinal and cross-sectional study

Background: Head circumference (HC) is a key indicator of growth and brain development in children, used to identify abnormalities like microcephaly and macrocephaly. While WHO growth standards are widely adopted, they may not account for regional variations due to genetic, environmental, and socio-economic factors. This study aimed to develop and validate national HC growth charts for Jordanian children aged 0–5 years and compare them with WHO standards. Methods: This study analysed 628456 HC measurements from 250276 Jordanian children (51.6% boys, 48.4% girls) aged 0–1800 days, using data from the Hakeem program. Only healthy children were included. HC measurements followed international guidelines, and data were analysed using the LMS statistical method. Percentiles were calculated, and growth patterns were compared with WHO standards. Results: National HC-for-age growth charts were developed for the 3rd, 15th, 50th, 85th, and 97th percentiles. Median percentiles for Jordanian children aligned with WHO standards, but the 3rd percentile was lower, particularly for girls after 840 days. The 97th percentile diverged after 240 days, with larger HC measurements observed in Jordanian children. Conclusions: This study provides the first validated HC growth charts for Jordanian children, addressing the limitations of international standards in reflecting regional variations. These charts offer clinicians and public health professionals a precise tool for assessing and monitoring growth, promoting better health outcomes in Jordanian children

Validation of the Arabic eHealth Literacy Questionnaire (eHLQ):a Factor and Rasch Analysis Study

Amidst the rapid digitalization of healthcare, there is a need for tools that accurately assess eHealth literacy across cultural contexts. This study focused on the validation of an Arabic version of the eHealth Literacy Questionnaire (eHLQ), a tool to facilitate patient engagement and health outcomes in digital healthcare. Using a convenience sampling method, the study recruited a diverse sample of 657 participants from Jordan (58.9% females and 41.1% males). Confirmatory Factor Analysis and Rasch analysis supported a six-factor model and demonstrated satisfactory item performance within established thresholds. The findings revealed good internal consistency with Cronbach’s α ranging between ranging between 0.71 to 0.84. Differential Item Functioning analysis indicated no gender-specific variations. The validated Arabic eHLQ is a reliable tool that can help in supporting the development of tailored interventions to improve healthcare delivery in Arabic-speaking regions

Health literacy and medication adherence among patients with type 2 diabetes in Jordan: A cross-sectional study

Background: Improving health literacy has been found to play a significant role in enhancing medication adherence in patients with type 2 diabetes.Purpose: The present study aims to evaluate health literacy and its association with medication adherence among diabetic patients in Jordan.Patients and Methods: This cross-sectional study included 400 diabetic patients, predominantly female (68.8%), with a median age of 58 years, attending the endocrinology outpatient clinic at Albasheer Hospital in Amman, Jordan, between August and December 2023. Patients were recruited using convenience sampling, including those aged 18 and older, literate, diagnosed with T2DM for at least one year, and on at least one medication for T2DM. Sample size was calculated based on the Events Per Variable (EPV) criterion to ensure sufficient power for logistic regression analysis. Data were collected using two validated instruments: the Jordanian Diabetic Health Literacy Questionnaire (JDHLQ), assessing health literacy, and the Medication Adherence Report Scale (MARS-5), measuring medication adherence. A binary logistic regression model was constructed to identify variables associated with adherence levels.Results: The study enrolled 400 diabetic patients (females =68.8%). While most of the participants (70.3%) reported high adherence levels, results revealed a window for health literacy improvement as the median for the JDHLQ score was 22 (ranging from 18 to 25) out of a maximum possible score of 32. More than half of the participants replied “never” to “I forget to take my medications”, followed by “I stop taking my medications for a while”.Conclusion: The binary regression model revealed that a higher JDHLQ score significantly increased the odds of a high adherence level. The significant association between improved health literacy and medication adherence necessitates the implementation of educational campaigns for enhancing literacy and hence medication adherence among patients with type 2 diabetes