49 research outputs found
Dampak Pembangunan Infrastruktur Perdesaan Pada Program PNPM Mandiri Perdesaan Di Kabupaten Toli Toli
The purpose of this study was to determine the Development Impact of Rural Infrastructure in PNPM RuralProgram in Toli-Toli. Research conducted on the implementation of PNPM Rural Program in Toli-Toli forfiscal year 2007 and 2008.Primary data obtained from interviews with relevant parties and direct observation in the field, then the datais processed with Descriptive Analysis.The results showed the impact of rural infrastructure development in poor communities in Toli Toli, namely:increasing revenue, impoving public education, improving health and improving the public midset. Impact onvillage institutions, namely: the function and role of local government to be effective, institutions ofparticipatory development and improvement of the quality of facilities.and social infrastructure andeconomic base of societ
Additional file 1 of Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study
Supplementary Table
Simple Fabrication of Glutathione-Responsive PEGylated Micellar Nanocarriers for Dual Drugs Delivery
<div><p>The authors report a feasible simple method to fabricate two kinds of micellar nanocarriers (MPEG-SS-CPT/DOX) with polyethylene glycol (PEG) based on the self-assembly of glutathione (GSH)-responsive amphiphilic PEGylated polymers (MPEG-SS-CPT) in free doxorubicin (DOX) solution, which could carry two anticancer drugs of camptothecin (CPT) and DOX toward cancer cells together. In in vitro release studies, the micelles of MPEG-SS-CPT/DOX could undergo the triggered disassembly to release CPT and DOX under GSH stimulus much faster than without GSH. Furthermore, the MPEG-SS-CPT nanocarriers could release CPT with no change of its original structure after degradation. From the experiments of loading and release of drugs, the cell viability assay, cellular uptake, and flow cytometry studies, it was found that the fibrous micelles modified by PEG with a molecular weight of 350 had greater potential in the field of drug delivery than the other with a molecular weight of 1900.</p></div
Highly Selective Fluorescent Probe Based on Hydroxylation of Phenylboronic Acid Pinacol Ester for Detection of Tyrosinase in Cells
The
detection of tyrosinase, a biomarker for melanoma, is of great
significance. Herein, a fluorescent tyrosinase probe, with resorufin
as the fluorophore and <i>m</i>-tolylboronic acid pinacol
ester as the receptor, is proposed. The response relies on the tyrosinase-catalyzed
hydroxylation of phenylboronic acid pinacol ester at an adjacent position
followed by 1,6-rearrangement elimination to release resorufin. This
probe well quantifies tyrosinase in the range from 1 to 100 U mL<sup>–1</sup> with a detection limit of 0.5 U mL<sup>–1</sup>. Importantly, the probe exhibits high selectivity for tyrosinase
over other biological substances including reactive oxygen species.
In addition, it is successfully applied to the imaging of tyrosinase
in cells. This probe provides a novel platform for selective detection
of tyrosinase in biosystems
DataSheet1_Quantitative source apportionment of heavy metals in atmospheric deposition of a typical heavily polluted city in Northern China: Comparison of PMF and UNMIX.docx
Receptor models are rarely utilized in atmospheric deposition but are often used to identify pollutant sources and quantify their contributions. This article focuses on the soil in atmospheric deposition in a typical polluted city. Atmospheric deposition has become an important route for exogenous heavy metals’ input into ecosystems. In this study, the heavy metals in atmospheric deposition were determined in three monitoring points arranged in Handan City. According to the functional area, fluxes, sources, and accumulation in the soil were explored. The sources of heavy metals were identified by PMF (positive matrix factorization) and UNMIX. The accumulation of heavy metals in the soil was predicted. The results showed that the deposition fluxes in industrial areas were higher than other functional areas. The mean concentrations of 8 heavy metals (Cd, Cr, Cu, Mn, Ni, Pb, Zn, and As) in the atmospheric deposition exceed their background values. PMF identified five major sources and UNMIX analyzed four sources. Similar source apportionment results were acquired via PMF and UNMIX, which were the combustion of fossil fuels, steel-smelting emission, road dust, and industrial sources. Steel-smelter emission was the highest source contributor. Therefore, combining these two models was the most effective approach, and more attention should be paid to mitigating the pollution caused by the industrial activities. The prediction indicated that the accumulation of heavy metals from atmospheric deposition to the soil would increase in 30 years, the growth rate of Cd increased significantly. The results of this study could provide reference in reduction of heavy metal pollution in atmospheric deposition.</p
The complete mitogenome of <i>Paratanakia chii</i> (Cypriniformes; Cyprinidae)
Paratanakia chii is a bitterling fish of the genus Paratanakia, subfamily Acheilognathinae and family Cyprinidae. The mitochondrial DNA sequence of P. chii is reported in this paper. The complete mitochondrial genome of P. chii is 16,575 bp in length, including 13 protein-coding genes (PCGs), 2 rRNA genes, 22 tRNA genes, and 1 displacement loop (D-loop). The genome sequence is consistent with those of most other carp. The majority of PCGs have AT- (Met) start codons and TA- end codons. The A + T contents of the genome, PCGs, transfer RNAs (tRNAs), and ribosomal RNAs (rRNAs) are 56.92%, 58.07%, 56.34%, and 54.21%, respectively. Phylogenetic analysis showed that P. chii is most closely related to Tanankia himantegus. These data will benefit relative ecological and phylogenetic studies.</p
Molecular Magnetic Investigation of a Family of Octanuclear [Cu<sub>6</sub>Ln<sub>2</sub>] Nanoclusters
Reaction
of in situ prepared acylhydrazone ligand with LnÂ(NO<sub>3</sub>)<sub>3</sub>·6H<sub>2</sub>O and CuÂ(OAc)<sub>2</sub>·H<sub>2</sub>O resulted in the formation of novel isostructural octanuclear Cu<sub>6</sub>Ln<sub>2</sub> compounds (Ln = Dy (<b>1</b>), Tb (<b>2</b>), Gd (<b>3</b>), Y (<b>4</b>)) with an unprecedented
octametallic structure, which can be described as an oblate wheel
built up from two structurally similar Cu<sub>3</sub> fragments linked
together by two nodelike mononuclear lanthanide units. A detailed
magnetic analysis reveals that the strong antiferromagnetic Cu···Cu
interactions via the Cu–N–N–Cu–N–N–Cu
linkage and the anticipated ferromagnetic Cu···Gd coupling
makes an overall high-spin ground state in favor of the observation
of significant magnetic caloric and SMM-like properties in the isotropic
and anisotropic derivatives
Comparison of the efficacy of drug treatment regimens in children with STSS.
Standard group: penicillin ± other antibiotics. Group A: carbapenems + glycopeptides/linezolid. Group B: Carbapenems, broad-spectrum antibiotics, and glycopeptides/linezolid alone or in combination, except for Group A. Group C: macrolides/unused antibiotics. Effective: The patient’s signs and symptoms disappeared or recovered completely after drug discontinuation, and laboratory test results returned to normal. Invalid: the patient’s symptoms and signs persisted, did not disappear completely, or even deteriorated after drug discontinuation, or new symptoms and signs appeared and/or new antimicrobial treatment measures were used. *P<0.05, **P<0.001.</p
Minimal data.
IntroductionStreptococcal toxic shock syndrome (STSS) is a severe consequence of infections from Streptococcus pyogenes. The early identification and timely intervention with appropriate anti-infective agents are pivotal for managing pediatric STSS. This study evaluates the effectiveness of various treatment regimens for STSS in children.MethodsClinical data of children with STSS resulting from β-hemolytic streptococcal infections in two hospitals were retrospectively analyzed from January 2009 to April 2023. Additionally, literature from the China National Knowledge Infrastructure on pediatric STSS was examined. Antimicrobial treatments were categorized into four groups based on their compositions, with an additional categorization for adjunct therapeutic drugs.ResultsOf 32 confirmed STSS cases, all displayed sensitivity to ampicillin, β-lactam antibiotics, and vancomycin, but resistance to clindamycin, erythromycin, and tetracycline. From the literature, 23 studies with 50 cases were extracted, leading to a total of 82 patients for evaluation. The efficacy rates varied significantly among the four treatment groups. Notably, the standard penicillin-containing group exhibited the highest efficacy (86.4%), while the group with macrolides/unused antibiotics registered a 0% efficacy rate. The other two groups demonstrated efficacy rates of 32.1% and 42.3%.ConclusionFor pediatric STSS, Streptococcus pyogenes shows notable sensitivity to ampicillin. Implementing timely β-lactam antibiotics, specifically penicillin, in conjunction with clindamycin and intravenous immunoglobulins enhances the treatment success rate.</div
Changes in expressions of mRNAs encoding caspase-3, caspase-8, c-FLIP<sub>L</sub> and c-FLIP<sub>S</sub> in primary human trophoblast cells result from infection are reverted upon IL-10 treatment.
<p>Caspase-3 (A) and caspase-8 (B) were both increased while c-FLIP<sub>S</sub> (C) and c-FLIP<sub>L</sub> (D) were decreased in infected cells relative to uninfected cells. Levels were reduced in infected cells treated with IL-10 compared to infected cells while no changes in treatment IL-10 in untreated cells relative to uninfected cells. * <i>p</i><0.05; ** <i>p</i><0.01.</p