Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients

Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Base

K-band spectroscopy of pre-cataclysmic variables

Aims. There exists now substantial evidence for abundance anomalies in a number of cataclysmic variables (CVs), indicating that the photosphere of the secondary star incorporates thermonuclear processed material. However, the spectral energy distribution in CVs is usually dominated by the radiation produced by the accretion process, severely hindering an investigation of the stellar components. On the other hand, depending on how the secondary star has acquired such material, the above mentioned abundance anomalies could also be present in pre-CVs, i.e. detached white/red dwarf binaries that will eventually evolve into CVs, but have not yet started mass transfer, and therefore allow for an unobstructed view on the secondary star at infrared wavelengths. Methods. We have taken K-band spectroscopy of a sample of 13 pre-CVs in order to examine them for anomalous chemical abundances. In particular, we study the strength of the 12CO and 13CO absorption bands that have been found diminished and enhanced, respectively, in similar studies of CVs. Results. All our systems show CO abundances that are within the range observed for single stars. The weakest 12CO bands with respect to the spectral type are found in the pre-CV BPM 71214, although on a much smaller scale than observed in CVs. Furthermore there is no evidence for enhanced 13CO. Taking into account that our sample is subject to the present observational bias that favours the discovery of young pre-CVs with secondary stars of late spectral types, we can conclude the following: 1) our study provides observational proof that the CO anomalies discovered in certain CVs are not due to any material acquired during the common envelope phase, and 2) if the CO anomalies in certain CVs are not due to accretion of processed material during nova outburst, then the progenitors of these CVs are of a significantly different type than the currently known sample of pre-CVs

Precise mass and radius values for the white dwarf and low mass M dwarf in the pre-cataclysmic binary NN Serpentis

We derive precise system parameters for the pre-cataclysmic binary, NN Ser. From light curve fitting we find an orbital inclination of i = 89.6 +/- 0.2 deg. From the HeII absorption line we find K_{WD}= 62.3 +/- 1.9 km/s. The irradiation-induced emission lines from the surface of the secondary star give a range of observed radial velocities. The corrected values give a radial velocity of K_{sec}= 301 +/- 3 km/s, with an error dominated by the systematic effects of the model. This leads to a binary separation of a = 0.934 +/- 0.009 R_{sun}, radii of R_{WD} = 0.0211 +/- 0.0002 R_{sun} and R_{sec} = 0.149 +/- 0.002 R_{sun} and masses of M_{WD} = 0.535 +/- 0.012 M_{sun} and M_{sec} = 0.111 +/- 0.004 M_{sun}. The masses and radii of both components of NN Ser were measured independently of any mass-radius relation. For the white dwarf, the measured mass, radius and temperature show excellent agreement with a `thick' hydrogen layer of fractional mass M_{H}/{M}_{WD} = 10^{-4}. The measured radius of the secondary star is 10% larger than predicted by models, however, correcting for irradiation accounts for most of this inconsistency, hence the secondary star in NN Ser is one of the first precisely measured very low mass objects to show good agreement with models. ULTRACAM r', i' and z' photometry taken during the primary eclipse determines the colours of the secondary star as (r'-i')_{sec}= 1.4 +/- 0.1 and (i'-z')_{sec} = 0.8 +/- 0.1 which corresponds to a spectral type of M4 +/- 0.5. This is consistent with the derived mass, demonstrating that there is no detectable heating of the unirradiated face, despite intercepting radiative energy from the white dwarf which exceeds its own luminosity by over a factor of 20.Comment: 20 pages, 17 figures, 8 tables, minor changes, accepted for publication in MNRA

Astroclimatic Characterization of Vallecitos: A candidate site for the Cherenkov Telescope Array at San Pedro Martir

We conducted an 18 month long study of the weather conditions of the Vallecitos, a proposed site in Mexico to harbor the northern array of the Cherenkov Telescope Array (CTA). It is located in Sierra de San Pedro Martir (SPM) a few kilometers away from Observatorio Astron\'omico Nacional. The study is based on data collected by the ATMOSCOPE, a multi-sensor instrument measuring the weather and sky conditions, which was commissioned and built by the CTA Consortium. Additionally, we compare the weather conditions of the optical observatory at SPM to the Vallecitos regarding temperature, humidity, and wind distributions. It appears that the excellent conditions at the optical observatory benefit from the presence of microclimate established in the Vallecitos.Comment: 16 pages, 16 figures, Publication of the Astronomical Society of the Pacific, accepte

The planets around NN Serpentis : still there

We present 25 new eclipse times of the white dwarf binary NN Ser taken with the high-speed camera ULTRACAM on the William Herschel Telescope and New Technology Telescope, the RISE camera on the Liverpool Telescope and HAWK-I on the Very Large Telescope to test the two-planet model proposed to explain variations in its eclipse times measured over the last 25 yr. The planetary model survives the test with flying colours, correctly predicting a progressive lag in eclipse times of 36 s that has set in since 2010 compared to the previous 8 yr of precise times. Allowing both orbits to be eccentric, we find orbital periods of 7.9 ± 0.5 and 15.3 ± 0.3 yr, and masses of 2.3 ± 0.5 and 7.3 ± 0.3 MJ. We also find dynamically long-lived orbits consistent with the data, associated with 2:1 and 5:2 period ratios. The data scatter by 0.07 s relative to the best-fitting model, by some margin the most precise of any of the proposed eclipsing compact object planet hosts. Despite the high precision, degeneracy in the orbit fits prevents a significant measurement of a period change of the binary and of N-body effects. Finally, we point out a major flaw with a previous dynamical stability analysis of NN Ser, and by extension, with a number of analyses of similar systems

DE Canum Venaticorum : a bright, eclipsing red dwarf–white dwarf binary

Context. Close white dwarf–red dwarf binaries must have gone through a common-envelope phase during their evolution. DE CVn is a detached white dwarf–red dwarf binary with a relatively short (∼8.7 h) orbital period. Its brightness and the presence of eclipses makes this system ideal for a more detailed study. Aims. From a study of photometric and spectroscopic observations of DE CVn we derive the system parameters that we discuss in the framework of common-envelope evolution. Methods. Photometric observations of the eclipses are used to determine an accurate ephemeris. From a model fit to an average lowresolution spectrum of DE CVn, we constrain the temperature of the white dwarf and the spectral type of the red dwarf. The eclipse light curve is analysed and combined with the radial velocity curve of the red dwarf determined from time-resolved spectroscopy to derive constraints on the inclination and the masses of the components in the system. Results. The derived ephemeris is HJDmin = 2 452 784.5533(1) + 0.3641394(2) × E. The red dwarf in DE CVn has a spectral type of M3V and the white dwarf has an effective temperature of 8 000 K. The inclination of the system is 86+3◦ −2 and the mass and radius of the red dwarf are 0.41 ± 0.06 M and 0.37+0.06 −0.007 R, respectively, and the mass and radius of the white dwarf are 0.51+0.06 −0.02 M and 0.0136+0.0008 −0.0002 R, respectively. Conclusions. We found that the white dwarf has a hydrogen-rich atmosphere (DA-type). Given that DE CVn has experienced a common-envelope phase, we can reconstruct its evolution and we find that the progenitor of the white dwarf was a relatively lowmass star (M ≤ 1.6 M). The current age of this system is 3.3−7.3 × 109 years, while it will take longer than the Hubble time for DE CVn to evolve into a semi-detached system

Interparticle interactions:Energy potentials, energy transfer, and nanoscale mechanical motion in response to optical radiation

In the interactions between particles of material with slightly different electronic levels, unusually large shifts in the pair potential can result from photoexcitation, and on subsequent electronic excitation transfer. To elicit these phenomena, it is necessary to understand the fundamental differences between a variety of optical properties deriving from dispersion interactions, and processes such as resonance energy transfer that occur under laser irradiance. This helps dispel some confusion in the recent literature. By developing and interpreting the theory at a deeper level, one can anticipate that in suitable systems, light absorption and energy transfer will be accompanied by significant displacements in interparticle separation, leading to nanoscale mechanical motion

Low-lying GT(+) strength in Co-64 studied via the Ni-64(d,He-2)Co-64 reaction

The Ni-64(d,He-2)Co-64 reaction was studied at the AGOR cyclotron of KVI, Groningen, with the Big-Bite Spectrometer and the EuroSuperNova detector using a 171-MeV deuteron beam. An energy resolution of about 110 keV was achieved. In addition to the J(pi) = 1(+) ground state, several other 1(+) states could be identified in Co-64 and the strengths of the corresponding Gamow-Teller transitions were determined. The obtained strength distribution was compared with theoretical predictions and former (n,p) experimental results and displayed a good agreement. Due to the good energy resolution, detailed spectroscopic information was obtained, which supplements the data base needed for network calculations for supernova scenarios

Sensitivity of a tonne-scale NEXT detector for neutrinoless double beta decay searches

The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta decay of Xe-136 using high-pressure xenon gas TPCs with electroluminescent amplification. A scaled-up version of this technology with about 1 tonne of enriched xenon could reach in less than 5 years of operation a sensitivity to the half-life of neutrinoless double-beta decay decay better than 1E27 years, improving the current limits by at least one order of magnitude. This prediction is based on a well-understood background model dominated by radiogenic sources. The detector concept presented here represents a first step on a compelling path towards sensitivity to the parameter space defined by the inverted ordering of neutrino masses, and beyond.Comment: 22 pages, 11 figure