Rapidly identify compounds from danshen by using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer and predict its mechanisms of intervening thrombotic diseases

Danshen, having good efficacies of dilating the coronary artery, improving microcirculation and preventing thrombosis, is widely used in clinic to treat various thrombotic diseases in China. This study aimed to identifying and analyzing the chemical constituents of Danshen from different planting areas based on UHPLC-LTQ-Orbitrap MS and comprehensively predicting the potential pharmacological targets and pathways of the main chemical constituents that involve in the treatment of thrombotic diseases by using network pharmacology. As a result, we identified 870 single peaks from total ion current and accurately identified 19 compounds from Danshen in this study. Further analysis showed that these compounds had three types of accumulation patterns and contents of most compounds had significant differences in samples from different planting areas. Network pharmacological analysis showed that Tanshinone IIA, Tanshinone IIB, Dehydromiltirone, Cryptotanshinone, Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone might intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system. This study provides a scientific basis for exploring the mechanism of Danshen in treating thrombotic diseases and controlling the quality of Danshen-related preparations. </p

MOESM1 of Transparent PAN:TiO2 and PAN-co-PMA:TiO2 Nanofiber Composite Membranes with High Efficiency in Particulate Matter Pollutants Filtration

Additional file 1: Figure S1. (a) SEM of cross-sectional PAN@TiO2 nanofiber membrane (b) SEM at 10 μm and (c) TEM imagine at 500 nm of PAN@TiO2 nanofiber membrane. (TiO2 content of 3%). Figure S2. EDS image of PAN@TiO2 nanofiber membrane. Figure S3. EDS image of C Kα1 (a) and Ti Kα1 (b). Figure S4. XRD of PAN-TiO2 nanofiber membrane. Figure S5. FTIR of PAN:TiO2 and PAN-co-PMA:TiO2 NFM(Nanofiber Membrane). Figure S6. Simulated polluted air test device. Figure S7. SEM of PAN nanofibers with(a) and without (b) the TiO2, PM2.5 filtration efficiency of PAN nanofibers &PAN:TiO2 nanofibers in Simulated polluted air test device (120min)

Highly Intrinsic Thermally Conductive Electrospinning Film with Intermolecular Interaction

A series of poly­(vinylidene fluoride) (PVDF)/poly­(vinyl alcohol) (PVA) composite films with different ratios were prepared by electrospinning. Because of the intermolecular interaction force, the highest thermal conductivity of the above film is 2.434 W m–1 K–1, which is about 60% higher than that of the pure PVDF film without a strong intermolecular interaction force. Infrared and wide-angle X-ray diffraction (WXAD) proved that PVDF as a thermal bridge enhances the internal interaction force and makes the internal structure more regular. The laser method shows that the film with strong intermolecular interaction has higher thermal diffusivity. Using molecular dynamics to explore the thermal expansion rate of the system, it is found that the intermolecular interaction force and the thermal bridge can effectively inhibit the activity of the molecular chain and reduce its free volume. After an in-depth study of the influence of the intermolecular interaction force and the thermal bridge on polymers, it is found that electrospinning can conveniently and effectively improve the ordering of the polymer structure. Integration of the electrospinning method and intermolecular interaction leads to the remarkable improvement of intrinsic thermal conductivity for polymer blends

Synthesis of 12-Connected Three-Dimensional Covalent Organic Framework with lnj Topology

The structural exploration of three-dimensional covalent organic frameworks (3D COFs) is of great significance to the development of COF materials. Different from structurally diverse MOFs, which have a variety of connectivity (3–24), now the valency of 3D COFs is limited to only 4, 6, and 8. Therefore, the exploration of organic building blocks with higher connectivity is a necessary path to broaden the scope of 3D COF structures. Herein, for the first time, we have designed and synthesized a 12-connected triptycene-based precursor (triptycene-12-CHO) with 12 symmetrical distributions of aldehyde groups, which is also the highest valency reported until now. Based on this unique 12-connected structure, we have successfully prepared a novel 3D COF with lnj topology (termed 3D-lnj-COF). The as-synthesized 3D COF exhibits honeycomb main pores and permanent porosity with a Brunauer–Emmett–Teller surface area of 1159.6 m2 g–1. This work not only provides a strategy for synthesizing precursors with a high connectivity but also provides inspiration for enriching the variety of 3D COFs