Frequencies of the haplotypes formed by rs17375018, rs7517847, rs1343151 and rs11209032 SNPs in AR patients and healthy control individuals.

<p>AR, allergic rhinitis; OR, odds ratio.</p

China’s Mismatch of Public Awareness and Biodiversity Threats under Economic Trade

China is one of the countries with high biodiversity on the globe, but suffers extreme biodiversity loss due to the increasingly interconnected economy. Understanding the nation-level public awareness of biodiversity under economic trades is crucial for implementing sustainable production and consumption of Sustainable Development Goals (SDGs). This study is the first to assess the public awareness of biodiversity loss associated with China’s interprovincial trades by utilizing social media data and the multiregion input–output (MRIO) table. Results show that China’s interprovincial trades cause heavy threats not only to local species but to distant species. Approximately 60% of provinces displace over half of their consumption-based biodiversity threats to other provinces. Nevertheless, individuals do not clearly realize their responsibility for the distant biodiversity they consumed, with a large mismatch both in popularity (Gini index = 0.51, Robin index = 39.57) and donation (Gini index = 0.69, Robin index = 54.58). To alleviate this phenomenon, our analysis suggests that the expansion of national-level nature reserves may be effectively beneficial to public biodiversity awareness, showing significantly positive partial correlation coefficients with individuals’ popularity and donations. These insights provided by this study offer targeted information for conservation and call for synergistic collaboration between the civil society, especially consumers, and governments to turn the tide of biodiversity loss

The 4 SNP call rates in patients and control individuals and HWE p-values.

<p>AR, allergic rhinitis, SNP; single-nucleotide polymorphism; HWE,Hardy-Weinberg equilibrium.</p

Clinical features and demographic characteristics of the study population.

<p>AR, allergic rhinitis.</p

Frequencies of alleles and genotypes of IL-23R polymorphisms in AR patients and control individuals.

<p>AR, allergic rhinitis; OR, odds ratio; SNP, single-nucleotide polymorphism.</p><p>Logistic regression analysis was used to analyze the genotype allele controlling for age, gender and occupation as the covariables.</p

China’s Mismatch of Public Awareness and Biodiversity Threats under Economic Trade

China is one of the countries with high biodiversity on the globe, but suffers extreme biodiversity loss due to the increasingly interconnected economy. Understanding the nation-level public awareness of biodiversity under economic trades is crucial for implementing sustainable production and consumption of Sustainable Development Goals (SDGs). This study is the first to assess the public awareness of biodiversity loss associated with China’s interprovincial trades by utilizing social media data and the multiregion input–output (MRIO) table. Results show that China’s interprovincial trades cause heavy threats not only to local species but to distant species. Approximately 60% of provinces displace over half of their consumption-based biodiversity threats to other provinces. Nevertheless, individuals do not clearly realize their responsibility for the distant biodiversity they consumed, with a large mismatch both in popularity (Gini index = 0.51, Robin index = 39.57) and donation (Gini index = 0.69, Robin index = 54.58). To alleviate this phenomenon, our analysis suggests that the expansion of national-level nature reserves may be effectively beneficial to public biodiversity awareness, showing significantly positive partial correlation coefficients with individuals’ popularity and donations. These insights provided by this study offer targeted information for conservation and call for synergistic collaboration between the civil society, especially consumers, and governments to turn the tide of biodiversity loss

Additional file 2 of RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Additional file 2

CRSsNP and CRSwNP are two distinct disease entities with respect to remodeling patterns.

<p>The hypothesis was supported by the significantly higher protein concentrations of activin A, follistatin, TGF-β1, and IFNγ and the lower concentrations of IL-5 and ECP, lower ratios of follistatin/activinA in CRSsNP compared with CRSwNP tissue homogenates, in line with predominant fibrosis in CRSsNP and edema in CRSwNP.</p

Protein expression of ECP, IL-5 and IFNγ in nasal tissue from CRSsNP (n = 13), CRSwNP (n = 23) and Control patients (inferior turbinate) (n = 10).

<p>IFNγ protein expression was significantly higher and IL-5 and ECP expression was significantly lower in CRSsNP compared with CRSwNP. Significance is indicated by P value.</p

The ratios of Follistatin/ActivinA and Follistatin/TGF-beta1 in nasal tissue and supernatants.

<p>There was an imbalance between pro-fibrotic (TGF-beta1, activin A) and anti-fibrotic (follistatin) mediators in CRSsNP (n = 9) and CRSwNP (n = 7). Statistical analysis was performed by using the Wilcoxon test (for paired comparisons). Significance is indicated by P value.</p