MOESM1 of Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Additional file 1: Figure S1. 1H-NMR bis(3-methoxybenzyl)carborane (1). Figure S2. 1H-NMR1,1′-(4-caboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one) (2). Figure S3. 1H-NMR (Z,Z′)-1,1′-(4-caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) (3). Figure S4. 1H-NMR (1Z,1′Z)-1,1′-(carboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one)-O,O-dipyridin-2-ylmethyldioxime (4). Figure S5. 1H-NMR (1Z,1′Z)-1,1′-(carboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one)-O,O-di(2-phenoxyethyl)dioxime (5). Figure S6. 1H-NMR (1Z,1′Z)-1,1’-(carboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one)-O,O-di(3-phenoxypropyl)dioxime (6). Figure S7. 1H-NMR (1Z,1′Z)-1,1’-(carboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one)-O,O-di(2-piperidin-1-ylethyl)dioxime (7). Figure S8. 1H-NMR (1Z,1′Z)-1,1’-(carboranyldimethyl)-bis(2-methoxy-4,1-phenylene-ethan-1-one)-O,O-di(2-morpholinoethyl)dioxime (8)

Media 1: Fast and effective occlusion culling for 3D holographic displays by inverse orthographic projection with low angular sampling

Originally published in Applied Optics on 20 September 2014 (ao-53-27-6287

Media 2: Fast and effective occlusion culling for 3D holographic displays by inverse orthographic projection with low angular sampling

Originally published in Applied Optics on 20 September 2014 (ao-53-27-6287

Media 3: Fast and effective occlusion culling for 3D holographic displays by inverse orthographic projection with low angular sampling

Originally published in Applied Optics on 20 September 2014 (ao-53-27-6287

Media 1: Fully computed holographic stereogram based algorithm for computer-generated holograms with accurate depth cues

Originally published in Optics Express on 23 February 2015 (oe-23-4-3901

DataSheet1_A porous form Coomassie brilliant blue G250-isorhamnetin fluorescent composite coated with acrylic resin for tumor cell imaging.docx

Four distinct fluorescence complexes, the fluorescent complex-1 (FC-1), fluorescent complex-2 (FC-2), fluorescent complex third (FC-3) and fluorescent complex fourth (FC-4), were created using isorhamnetin and Coomassie brilliant blue G250 as raw materials. The issue of isorhamnetin’s low solubility has been resolved, and isorhamnetin-coomassie brilliant blue G250 now has better biocompatibility. Four different forms of fluorescence compounds’ ultraviolet absorption spectra were identified. It was discovered that FC-2, FC-3, and FC-4, respectively, had double peaks at 483–620 nm. FC-4 had the highest ultraviolet absorption intensity, whereas FC-1 exhibited the most consistent and longest wavelength of ultraviolet absorption. Transmission electron microscopy revealed that the acrylic resin evenly disseminated the Coomassie brilliant blue G250-isorhamnetin complex in an amorphous flocculent form. Human prostate cancer cells (PC3) and human cervical cancer cells (HeLa) were investigated in the (Cell Counting Kit-8) CCK8 experiment under 10 different concentration circumstances, and the proliferation impact was 64.30% and 68.06%, respectively. Shown the complex’s strong anti-tumor properties and minimal cytotoxicity. Through in vitro imaging of tumor cells, it was found that FC-1’s fluorescent complex has high selectivity and can accurately infiltrate tumor cells, proving that it is biocompatible. The design not only addresses the issue of isorhamnein-Coomassie Bright Blue G250’s bioavailability, but it also has an effective visual fluorescence targeting effect.</p

DataSheet1_Symmetry dual functional pyrimidine-BODIPY probes for imaging targeting and activity study.docx

Nondestructive diagnosis of tumor has always been the goal of scientists. Fluorescent dyes have become the rising star in the field of cancer diagnosis because of their excellent characteristics. Therefore, in this work, fluorescence probes d-Y-B and dO-Y-B with anti-tumor activity were constructed by introducing pyrimidine groups with high anti-tumor activity using fluorescence dye BODIPY as parent nucleus. The modified BODIPY group in the structure had the advantage of fluorescent dye, ensuring the strong fluorescence and photosensitivity of the target compound. That ethylenediamine acts as a bridge with two -NH- groups to increase molecular hydrogen bonding, and can bind firmly to multiple proteins. Co-localization of the target compounds d-Y-B and dO-Y-B with the hoechst dye for labeling living cells showed that these compounds had high biocompatibility and photostability for localization to HeLa cells. In vivo imaging in mice can realize specific localization and real-time visualization of tumor cells. The results of cytotoxicity experiments in vitro and computer software simulating molecular docking confirmed the potential of the target compounds as an anticancer agents. The bifunctional probe realized visualization of cancer cells in mice, and can kill cancer cells by anti-proliferation, which may provide a direction for future anticancer drug development.</p

Visualization 1.avi

Visualization 1 shows the two-dimensional sinusoidal pattern illuminated the sample during phase shift

Visualization 1: Accurate calculation of computer-generated holograms using angular-spectrum layer-oriented method

The optical reconstruction of a rotating hall. Originally published in Optics Express on 05 October 2015 (oe-23-20-25440

Incoherent Optoelectronic Differentiation with Optimized Multilayer Films

Fourier-based optical computing operations, such as spatial differentiation, have recently been realized in compact form factors using flat optics. Experimental demonstrations, however, have been limited to coherent light requiring laser illumination and leading to speckle noise and unwanted interference fringes. Here, we demonstrate the use of optimized multilayer films, combined with dual color image subtraction, to realize differentiation with unpolarized incoherent light. Global optimization is achieved by employing neural networks combined with the reconciled level set method to optimize the optical transfer functions of multilayer films at wavelengths of 532 nm and 633 nm. Spatial differentiation is then achieved by subtracting the normalized incoherent images at these two wavelengths. The optimized multilayer films are experimentally demonstrated to achieve incoherent differentiation with a numerical aperture up to 0.8 and a resolution of 6.2 {\mu}m. The use of multilayer films allows for lithography-free fabrication and is easily combined with existing imaging systems opening the door to applications in microscopy, machine vision and other image processing applications