Appendix – Supplemental material for Collapse resistance of steel frames with concrete slabs due to penultimate-side column loss

Supplemental material, Appendix for Collapse resistance of steel frames with concrete slabs due to penultimate-side column loss by Guo-Qiang Li, Jing-Zhou Zhang and Jian Jiang in Advances in Structural Engineering</p

Cytotoxic components from the Xisha sponge <i>Fascaplysinopsis reticulata</i>

A new dolabellane diterpenoid, clavirolide H (1), together with eleven known compounds, including two dolabellane diterpenoid (2 and 3), a rare cavernosine-type C17 γ-lactone terpenoid (4), a diketopiperazine (5) and seven sterols (6–12), were isolated from the Xisha sponge Fascaplysinopsis reticulata. Their structures were elucidated by extensive spectroscopic analysis, and the four types of compounds of the above isolates were reported from the genus Fascaplysinopsis for the first time. Selected compounds 1, 4–6 and 9–12 were evaluated for cytotoxic activities against K562, HL-60, Hela, HCT-116, A549, L-02 and BEL-7402 cell lines. Compounds 4–6 and 10–12 showed potent cytotoxicitives against HL-60 with IC50 values ranging from 8.8 to 12.4 μM. Compounds 4 and 5 exhibited weak cytotoxic activities against HeLa with IC50 of 20.7 and 27.4 μM, and 5 also has moderate cytotoxicity against HCT-116 with IC50 of 16.3 μM.</p

A new lignan from the roots of <i>Syringa pinnatifolia</i>

<div><p>Phytochemical investigation of the roots of <i>Syringa pinnatifolia</i> has resulted in the isolation of a new lignan, pinnatifolin A (<b>1</b>), together with seven known compounds (<b>2</b>–<b>8</b>). The structures were elucidated on the basis of extensive spectroscopic methods, including NMR, MS, UV and IR spectra. The seven lignans were screened for their antioxidant activity (DPPH assay), and most of them showed potent antioxidant activity.</p></div

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Terpenoids from the South China Sea soft coral <i>Sinularia multiflora</i>

A rare sinulariane-type norcembranoid sinulariadiolide B (1) with a unique cyano group, and a eunicellin-based diterpenoid multifloralin (2), along with two known related analogues, sinulariadiolide (3) and sclerophytin E (4), were isolated from the extract of the South China Sea soft coral Sinularia multiflora. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison with previously reported data. Compounds 2 and 4 showed potent antifouling activity against barnacle Balanus albicostatus.</p

Two new eunicellin diterpenoids from the South China Sea gorgonian <i>Muricella sibogae</i> and their bioactivities

<p>A systematic re-study on gorgonian <i>Muricella sibogae</i> from South China Sea yielded 10 eunicellin-based diterpenoids including two new ones, sibogins C and D (<b>1</b> and <b>2</b>). Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, IR and MS) and by comparison with data reported in literatures. All the isolates were tested for cytotoxic and antifouling activities. Compounds <b>3</b> and <b>5</b> showed significant antifouling activity against the green mussel <i>Perna viridis</i>, and especially <b>3</b> was suggested as a potent low-toxic antifouling agent with a large LC₅₀/EC₅₀ value of 18.6. This was the first report on the antifouling activity of the eunicellin-type diterpenoids against the green mussel.</p

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay