Additional file 1 of Long-term exposure to ambient PM2.5 and its components on menarche timing among Chinese adolescents: evidence from a representative nationwide cohort

Supplementary Material

Iridium/Copper Co-catalyzed <i>Anti</i>-Stereoselective Ring Opening of Oxabenzonorbornadienes with Grignard Reagents

Cooperative catalysis has been widely considered as one of the most powerful strategies to improve synthetic efficiency. A new iridium/copper cocatalyst was developed for the ring-opening reaction of oxabenzonorbornadienes with a wide variety of Grignard reagents, which afforded the corresponding <i>anti</i>-2-substituted 1,2-dihydronaphthalen-1-ols in high yields (up to 99% yield) under mild conditions. The effects of catalyst loading, Lewis acid, Grignard reagent loading, and reaction temperature on the yield were investigated. To the best of our knowledge, it represents the first example of ring-opening reactions of oxabicyclic alkenes with Grignard reagent nucleophiles in a <i>trans</i>-stereoselective manner

Palladium-Catalyzed <i>syn</i>-Stereocontrolled Ring-Opening of Oxabicyclic Alkenes with Sodium Arylsulfinates

Palladium-catalyzed <i>syn</i>-stereocontrolled ring-opening reactions of oxabenzonorbornadienes with a wide range of sodium arylsulfinates were investigated, affording the desired products in good to excellent yields under an air atmosphere. This protocol provides a low-cost new viable and convenient method toward the synthesis of <i>cis</i>-2-aryl-1,2-dihydronaphthalen-1-ol with good functional group tolerance. In addition, the <i>cis</i> configuration of <b>3da</b> was established by X-ray diffraction analysis, and a plausible mechanism for the ring-opening reaction was proposed

Additional file 1: of Higher serum 25(OH)D level is associated with decreased risk of impairment of glucose homeostasis: data from Southwest China

Table S1. The diagnosis of pre-diabetes (n = 1514). (DOCX 16 kb

Additional file 2: of Higher serum 25(OH)D level is associated with decreased risk of impairment of glucose homeostasis: data from Southwest China

Table S2. Multiple logistic regression odds ratio (OR) and 95% confidence interval (CI) for the association of tertiles of serum 25(OH)D (ng/ml) with pre-diabetes1 (DOCX 18 kb

Seminário Suporte à pesquisa e gestão de dados científicos: panorama atual e desafios, 1.: materiais de divulgação

Primeiro Seminário Suporte à pesquisa e gestão de dados científicos: panorama atual e desafios, realizado entre os dias 18 e 19 de setembro de 2017, no Auditório do Espaço Físico Integrado, da UFSC. Contém banner e folder produzidos para divulgação do evento, elaborados pela estagiária Aila Lima. Banner armazenado na arara 26 do arquivo deslizante da Memória Documental BU.PGCIN/UFSC e Biblioteca Universitária/UFSC

Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study

<div><p>Cardioprotection of dexrazoxane (DZR) against doxorubicin (DOX)-induced cardiotoxicity is contentious and the indicator is controversial. A pairwise comparative metabolomics approach was used to delineate the potential metabolic processes in the present study. Ninety-six BALB/c mice were randomly divided into two supergroups: tumor and control groups. Each supergroup was divided into control, DOX, DZR, and DOX plus DZR treatment groups. DOX treatment resulted in a steady increase in 5-hydroxylysine, 2-hydroxybutyrate, 2-oxoglutarate, 3-hydroxybutyrate, and decrease in glucose, glutamate, cysteine, acetone, methionine, asparate, isoleucine, and glycylproline.DZR treatment led to increase in lactate, 3-hydroxybutyrate, glutamate, alanine, and decrease in glucose, trimethylamine N-oxide and carnosine levels. These metabolites represent potential biomarkers for early prediction of cardiotoxicity of DOX and the cardioprotective evaluation of DZR.</p></div

Platinum-Catalyzed Asymmetric Ring-Opening Reactions of Oxabenzonorbornadienes with Phenols

A platinum­(II)-catalyzed asymmetric ring opening of oxabenzonorbornadienes with phenols was developed, which afforded the corresponding <i>cis</i>-2-(un)­substituted phenoxy-1,2-dihydronaphthalen-1-ol products rather than the <i>trans</i> ones in excellent yields (up to 99%) with moderate to good enantioselectivities (up to 87% ee) under mild conditions. In addition, the <i>cis</i>-configuration of product <b>2b</b> was confirmed by X-ray diffraction analysis. Based on the results, a potential mechanism for the present catalytic reaction was proposed

DZR protected against DOX-induced myocardial damage.

<p>Histopathology of HE staining of left ventricular walls indicated myocardial damage and cardioprotective effects of DZR(<b>A</b>). Magnification200x. DZR abrogated DOX-induced increase serum creatine kinase (<b>B</b>),CK-MB(<b>C</b>), cardiac LDH(D), cTNT(E), as well as decrease cardiac total glutathione (F) and GSH/GSSH ratio (G).</p

Overall profiling of the eight groups and abnormal metabolism in cancer.

<p>Score plot of the eight groups (A) shows treatment differences. The summary of pairwise metabolomics analysis of the model represents the cumulative R2X, R2Y and Q2 levels (<b>B</b>). The score plot and S-plot of the pairwise analysis of cancer and control groups reveal altered metabolites including creatine, UDP-glucose, VLDL/LDL, glycerol, TMAO, taurine, carnosine, lactate, acetone, glutamate, and aspartate (<b>C</b>).</p