Optimization of Reaction Conditions in the Production of Gadolinium Diethylenetriamine Pentaacetate-Folate

A previous study has performed the laboratory-scale synthesis and characterization of Gadolinium Diethylenetriaminepentaacetate-Folate. Some parameters associated with the synthesis have been defined. In current study was focused on establishment the parameters for scaling up the production of Gadolinium Diethylenetriaminepentaacetate-Folate as a targeted MRI contrast agent. For the purpose of subsequent scaling up the synthesis, the parameters particularly those determining the yield of the reaction product should be established. This report presents the use of The Placket Burman Design and the Response Surface Methodology in establishing the parameters. Thus, following the Placket Burman Design, a number of synthesis reactions were carried out, each with different reaction conditions, with respect to parameters to include: mole ratio of reactants (i.e mole of Gd3+ to DTPA-Folate), time of reaction, temperature, stirring rate, pH and solvent volume. Using this method, a conclusion could be drawn that the three factors were found to be significant. To get final conclusions on the optimal synthesis reaction conditions, the Response Surface Methodology was then applied. For this purpose, again, some synthesis reactions experiments were performed. These were done, in accordance to the Response Surface Methodology, verified by analysis of countour plots, helped to locate the optimal value of the factors. The resulted data showed that for optimal yield of the synthesis reaction there were three dominant parameters. They were mole ratio of reactants, stirring rate process, and the volume of water

Implementasi Linear Congruent Method untuk Pengacakan Soal pada Game Perhitungan Jarimatika Berbasis Android

Perjalanan teknologi telah mengalami langkah maju yang sangat menakjubkan, terutama bidang komputer pada khususnya. Kecanggihan komputer terletak pada banyaknya data penyampaian informasi. SDIT baitul izzah merupakan sekolah dasar yang memiliki basis agama yang kuat, sistem pembelajaran pada SDIT baitul izzah berbeda dengan sekolah dasar yang konvensional. Metode linear congruent method (LCM) merupakan proses menurunkan secara acak nilai variabel tidak pasti secara berulang-ulang untuk mensimulasikan model. Bermain sambil belajar dan merasa tertantang dengan teknik jarimatika tidak membebani memori otak peserta didik. Teknik berhitung jarimatika mampu menyeimbangkan kerja otak kanan dan kiri, hal itu dapat ditunjukkan pada waktu berhitung mereka akan mengotak-atik jari-jari tangan kanan dan kirinya secara seimbang. bagaimana membuat perhitungan jarimatika berbasis smartphone android menggunakan metode Linear Congruent Method. Tujuan penelitian ini adalah untuk membuat perhitungan jarimatika berbasis androi

Association of Calpastatin (CAST) Gene with Growth Traits and Carcass Characteristics in Bali Cattle

Calpastatin (CAST) gene is well known as an inhibitor of muscle protein degradation and relates to muscle growth and meat tenderness. The objective of this study was to determine the association of CAST gene with growth traits and carcass characteristics in Bali cattle. A number of data from 35 Bali bulls were collected from BPTU Bali Cattle to obtain growth traits, carcass characteristics, and blood samples. Polymorphism of CAST gene in Bali bulls was analyzed by using PCR-RFLP and DNA sequencing. The association of CAST gene with growth traits and carcass characteristics were analyzed by using General Linear Model (GLM). The result showed that there were two genotypes (GG and AG) of CAST gene with allele frequencies of 0.857 and 0.143, respectively, for G and A. Notably, mutation A to G occurred in 253 bp CAST fragment gene in Bali Cattle. Genotypes GG and AG of CAST gene significantly affected (P<0.05) the back-fat thickness and longissimus dorsi without a significant effect on the growth traits. It could be concluded that CAST gene had a potency as a marker gene for carcass quality in Bali cattle

Analisi Pengaruh Store Name, Brand Name, Dan Price Discounts Terhadap Purchase Intentions Konsumen Infinite Tunjungan Plaza

Andy Gunawan:SkripsiAnalisis pengaruh store name, brand name dan price discounts terhadap purchase intention konsumen infnite tunjungan plaza Di era globalisasi ini, persaingan dagang antara Perusahaan – Perusahaan baik lokal maupun global menjadi semakin ketat, oleh karena itu Perusahaan selalu berusaha untuk meningkatkan ketertarikan minat beli konsumen. Beberapa variabel yang menjadi fokus Perusahaan adalah store name, brand name, dan price discount. Tujuan penelitian ini adalah untuk menganalisa pengaruh store name, brand name, dan price discount terhadap purchase intention. Obyek yang diangkat dalam penelitian ini adalah infinite tunjungan plaza surabaya, dan sampelnya adalah konsumen infinite tunjungan plaza.Hasil penelitian store name berpengaruh positif terhadap purchase intention. Brand name berpengaruh positif terhadap purchase intention. Price discount berpengaruh positif terhadap purchase intention

Pengaruh Motivasi dan Kepuasan Kerja terhadap Kinerja Karyawan Muntaza Tours & Travel Cibubur.

Motivation and Satisfiction are the two factors of a few relatively large factors suspected to influencePerformance on the Muntaza Tours and Travel Cibubur. These research aimed to determine the effect ofMotivation and Satisfiction toward Performance on Muntaza Tours and Travel Cibubur.Research conducted at the Muntaza Tours and travel by taking 36 employees as the research sample.Data were collected by questionnaire instruments covered by the five rating scale from strongly disagreeto strongly agree. Quantitative research was conducted by describing and analyzing research data. Themultiple linier regression analysis and multiple determination coeficient are the statistic approach to dataanalysis.The study produced three major findings consistent with the hypothesis put forward, that are: 1)Motivation has a significant effect on performance in a positive direction; 2) Satisfiction has a significanteffect on Performance in a positive direction; 3) Motivation and Satisfiction simultaneously influence 94.10%Performance variability. Base on the research finding, in order to increase Performance can be done by increasing Motivationand Satisfiction