8 research outputs found
Schematized setup of the “spatial compatibility” experiment.
<p>The arrow indicates the direction of chickpeas displacement.</p
Publications on the topic of action observation in the last 3 decades.
<p>The ncbi/PubMed database has been searched for the phrases “action observation” OR “action understanding” in the indicated time-intervals. The resulting number of records has been normalized by the total number of publications indexed in PubMed in the corresponding time-interval. The result has been multiplied by 10<sup>Λ</sup>6 for plotting convenience.</p
Results of the “semantic reference” experiment.
<p>The solid lines represent individual data and the gray bars represent the group averaged values.</p
Set of stimuli used in the present experiment.
<p>The ambiguous contact point used for analysis is labeled as “0”.</p
Schematized setup of the “semantic reference” experiment.
<p>The arrow indicates the direction of chickpeas displacement.</p
Results of the “spatial compatibility” experiment.
<p>The solid lines represent individual data and the gray bars represent the group averaged values.</p
Data_Sheet_1_M1-P15 as a cortical marker for transcallosal inhibition: A preregistered TMS-EEG study.pdf
In a recently published study combining transcranial magnetic stimulation and electroencephalography (TMS-EEG), an early component of TMS-evoked potentials (TEPs), i.e., M1-P15, was proposed as a measure of transcallosal inhibition between motor cortices. Given that early TEPs are known to be highly variable, further evidence is needed before M1-P15 can be considered a reliable index of effective connectivity. Here, we conceived a new preregistered TMS-EEG study with two aims. The first aim was validating the M1-P15 as a cortical index of transcallosal inhibition by replicating previous findings on its relationship with the ipsilateral silent period (iSP) and with performance in bimanual coordination. The second aim was inducing a task-dependent modulation of transcallosal inhibition. A new sample of 32 healthy right-handed participants underwent behavioral motor tasks and TMS-EEG recording, in which left and right M1 were stimulated both during bimanual tasks and during an iSP paradigm. Hypotheses and methods were preregistered before data collection. Results show a replication of our previous findings on the positive relationship between M1-P15 amplitude and the iSP normalized area. Differently, the relationship between M1-P15 latency and bimanual coordination was not confirmed. Finally, M1-P15 amplitude was modulated by the characteristics of the bimanual task the participants were performing, and not by the contralateral hand activity during the iSP paradigm. In sum, the present results corroborate our previous findings in validating the M1-P15 as a cortical marker of transcallosal inhibition and provide novel evidence of its task-dependent modulation. Importantly, we demonstrate the feasibility of preregistration in the TMS-EEG field to increase methodological rigor and transparency.</p