11 research outputs found
Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female mice
Our previous work revealed the microbiota-dependent beneficial effects of inulin in obese male mice, but the effects in obese female mice were not determined. High-fat diet (HFD)-induced obese female mice were switched to normal diets and gavaged with normal saline or inulin for 10 weeks. Inulin supplementation significantly accelerated weight loss and reversed HFD-induced gut microbiota dysbiosis in obese female mice, and also reduced the ratio of Firmicutes/Bacteroidetes and enriched the abundance of norank_f_Muribaculaceae and Alistipes. In addition, 52 key serum metabolites were distinctly altered after inulin supplementation. Among them, andrographolide and monoacylglycerols (18:4) increased more than 9-fold and 14-fold, respectively, while phosphatidylcholine (PC) (18:1e/2:0), PC (20:1/20:2) and PC (19:1/19:1) decreased. In conclusion, gut microbiota and metabolites were closely associated with the beneficial effects of inulin in accelerating weight loss in obese female mice.</p
Biobased Inverse Vulcanized Polymer from Magnolol as a Multifunctional Ingredient for Carbon-Black-Reinforced Rubber Composites
Inverse
vulcanization provides a facile route to transform industrial
byproduct sulfur into attractive polymeric materials with a variety
of applications. Herein, an inverse vulcanized copolymer (PSM) was
synthesized by copolymerization of biomass magnolol and sulfur. PSM
presents outstanding intrinsic flame retardancy by the formation of
a highly pyrolysis-resistant carbonaceous material during combustion.
Especially, it can serve as a multifunctional ingredient when utilized
in rubber composites. The presence of polysulfide segments and biphenol
moieties enables PSM to cross-link rubber effectively and react with
the oxygenic groups on the surface of carbon black (CB), thus resulting
in the improvement of CB dispersion and stronger interfacial interaction
between a rubber matrix and nanofillers than the conventional sulfur-cross-linked
rubber composite. Incorporation of PSM also significantly retards
the thermo-oxidation aging of the composites due to its radical scavenging
capability. Moreover, the dynamic covalent polysulfide segments in
the system confer the PSM-cross-linked rubber material reprocessability
and recyclability
Biobased Inverse Vulcanized Polymer from Magnolol as a Multifunctional Ingredient for Carbon-Black-Reinforced Rubber Composites
Inverse
vulcanization provides a facile route to transform industrial
byproduct sulfur into attractive polymeric materials with a variety
of applications. Herein, an inverse vulcanized copolymer (PSM) was
synthesized by copolymerization of biomass magnolol and sulfur. PSM
presents outstanding intrinsic flame retardancy by the formation of
a highly pyrolysis-resistant carbonaceous material during combustion.
Especially, it can serve as a multifunctional ingredient when utilized
in rubber composites. The presence of polysulfide segments and biphenol
moieties enables PSM to cross-link rubber effectively and react with
the oxygenic groups on the surface of carbon black (CB), thus resulting
in the improvement of CB dispersion and stronger interfacial interaction
between a rubber matrix and nanofillers than the conventional sulfur-cross-linked
rubber composite. Incorporation of PSM also significantly retards
the thermo-oxidation aging of the composites due to its radical scavenging
capability. Moreover, the dynamic covalent polysulfide segments in
the system confer the PSM-cross-linked rubber material reprocessability
and recyclability
Biobased Inverse Vulcanized Polymer from Magnolol as a Multifunctional Ingredient for Carbon-Black-Reinforced Rubber Composites
Inverse
vulcanization provides a facile route to transform industrial
byproduct sulfur into attractive polymeric materials with a variety
of applications. Herein, an inverse vulcanized copolymer (PSM) was
synthesized by copolymerization of biomass magnolol and sulfur. PSM
presents outstanding intrinsic flame retardancy by the formation of
a highly pyrolysis-resistant carbonaceous material during combustion.
Especially, it can serve as a multifunctional ingredient when utilized
in rubber composites. The presence of polysulfide segments and biphenol
moieties enables PSM to cross-link rubber effectively and react with
the oxygenic groups on the surface of carbon black (CB), thus resulting
in the improvement of CB dispersion and stronger interfacial interaction
between a rubber matrix and nanofillers than the conventional sulfur-cross-linked
rubber composite. Incorporation of PSM also significantly retards
the thermo-oxidation aging of the composites due to its radical scavenging
capability. Moreover, the dynamic covalent polysulfide segments in
the system confer the PSM-cross-linked rubber material reprocessability
and recyclability
The concentrations of Ang II and NA in serum during the progression of HFMD.
<p>All HFMD cases were divided into different subsets of 1, 2, 3, 4, 5 days post infection (dpi) based on the hospitalization and initial onset time. The concentrations of Ang II and NA in serum of cases were determined using ELISA kits. Data are expressed as mean ± SEM. *<i>P</i><0.05.</p
The concentrations of Ang II and NA in tissue lysates of EV71-infected mice.
<p>Mice were sacrificed on 3, 5, 7 dpi, and the brains, skeletal muscle and lungs of mice were removed. Then the tissue was weighted and lysated by cold PBS, followed by centrifugation at 3,000×g for 10 min at 4°C. The concentrations of Ang II and NA were determined using ELISA kits. Data are expressed as mean ± SEM. *<i>P</i><0.05.</p
The concentrations of Ang II and NA in serum.
<p>The concentrations of Ang II and NA in serum were determined using ELISA kits. Data are expressed as mean ± SEM. *<i>P</i><0.001.</p
Correlation analysis of Ang II and NA.
<p>Pearson’s correlation test was used to analyze the relationship between Ang II and NA in serum of all subjects, r = Pearson correlation coefficient.</p
Histopathological alterations in brains, skeletal muscle, lungs of EV71-infected mice.
<p>Mice were sacrificed on 3, 5, 7 dpi. The removed organ or tissue were sliced and stained with H&E. Brain from EV71-infected mice exhibited perivascular cuffing (indicated by red solid arrows). Skeletal muscle from EV71-infected mice appeared necrotizing myositis with muscle fibers rupture (indicated by orange solid arrows) at 5 dpi and 7 dpi. Erythrocyte-filled fluid in the alveolar spaces was found in lungs (indicated by black solid arrows) from EV71-infected mice at 7 dpi. Bar = 100μm.</p
Additional file 3: Figure S2. of Pulmonary edema following central nervous system lesions induced by a non- mouse-adapted EV71 strain in neonatal BALB/c mice
Weight loss after ZZ1350 infection. Body weight of mice (n = 7 for intracerebral inoculation; n = 6 for intramuscular inoculation; n = 6 for intraperitoneal inoculation and n = 5 for normal controls) was recorded every 2 days after ZZ1350 infection. Data are expressed as mean ± SEM. (TIFF 382 kb