Image_1_DC Shifts-fMRI: A Supplement to Event-Related fMRI.JPEG

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_3_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_4_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_2_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_1_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_6_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Audio_5_DC Shifts-fMRI: A Supplement to Event-Related fMRI.WAV

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed. Direct-current EEG shifts (DC shifts) have been found linked to the inner brain activity, a fusion DC shifts-fMRI method may have the ability to reveal a more complete response of the brain. In this study, we used DC shifts-fMRI to verify that even when responding to a very simple task, (1) The response of the brain is more complicated than event-related fMRI generally revealed and (2) DC shifts-fMRI have the ability of revealing brain regions whose responses are not in event-related way. We used a classical and simple paradigm which is often used in auditory cortex tonotopic mapping. Data were recorded from 50 subjects (25 male, 25 female) who were presented with randomly presented pure tone sequences with six different frequencies (200, 400, 800, 1,600, 3,200, 6,400 Hz). Our traditional fMRI results are consistent with previous findings that the activations are concentrated on the auditory cortex. Our DC shifts-fMRI results showed that the cingulate-caudate-thalamus network which underpins sustained attention is positively activated while the dorsal attention network and the right middle frontal gyrus which underpin attention orientation are negatively activated. The regional-specific correlations between DC shifts and brain networks indicate the complexity of the response of the brain even to a simple task and that the DC shifts can effectively reflect these non-event-related inner brain activities.</p

Image_1_Single-Trial EEG-fMRI Reveals the Generation Process of the Mismatch Negativity.JPEG

Although research on the mismatch negativity (MMN) has been ongoing for 40 years, the generation process of the MMN remains largely unknown. In this study, we used a single-trial electro-encephalography (EEG)-functional magnetic resonance imaging (fMRI) coupling method which can analyze neural activity with both high temporal and high spatial resolution and thus assess the generation process of the MMN. We elicited the MMN with an auditory oddball paradigm while recording simultaneous EEG and fMRI. We divided the MMN into five equal-durational phases. Utilizing the single-trial variability of the MMN, we analyzed the neural generators of the five phases, thereby determining the spatiotemporal generation process of the MMN. We found two distinct bottom-up prediction error propagations: first from the auditory cortex to the motor areas and then from the auditory cortex to the inferior frontal gyrus (IFG). Our results support the regularity-violation hypothesis of MMN generation.</p

Table_1_Effects of Musical Tempo on Musicians’ and Non-musicians’ Emotional Experience When Listening to Music.PDF

Tempo is an important musical element that affects human’s emotional processes when listening to music. However, it remains unclear how tempo and training affect individuals’ emotional experience of music. To explore the neural underpinnings of the effects of tempo on music-evoked emotion, music with fast, medium, and slow tempi were collected to compare differences in emotional responses using functional magnetic resonance imaging (fMRI) of neural activity between musicians and non-musicians. Behaviorally, musicians perceived higher valence in fast music than did non-musicians. The main effects of musicians and non-musicians and tempo were significant, and a near significant interaction between group and tempo was found. In the arousal dimension, the mean score of medium-tempo music was the highest among the three kinds; in the valence dimension, the mean scores decreased in order from fast music, medium music, to slow music. Functional analyses revealed that the neural activation of musicians was stronger than those of non-musicians in the left inferior parietal lobe (IPL). A comparison of tempi showed a stronger activation from fast music than slow music in the bilateral superior temporal gyrus (STG), which provided corresponding neural evidence for the highest valence reported by participants for fast music. Medium music showed stronger activation than slow music in the right Heschl’s gyrus (HG), right middle temporal gyrus (MTG), right posterior cingulate cortex (PCC), right precuneus, right IPL, and left STG. Importantly, this study confirmed and explained the connection between music tempo and emotional experiences, and their interaction with individuals’ musical training.</p

Graphene-Impregnated Paper-Based Electronic Skins for Robotic Intelligence and Wireless Health Monitoring

Due to favorable electrical, mechanical, and stability properties of two-dimensional graphene (G), electronic skins (E-skins) were fabricated here based on G-impregnated paper (G-I paper) and interdigitated electrodes (IDEs), and multiple signals could be successfully detected, including pressure and humidity. The pressure-sensitive (P-S) E-skin showed a relatively large pressure detection range of 0–18.9 kPa, and its GF values were 0.96 and 0.44 kPa–1 with ranges of 1.5 × 10–2–7.2 and 7.2–18.9 kPa, respectively. For the humidity-sensitive (H-S) E-skin, its GF values were 2.62 × 10–2 and 0.55 with RH ranges of 25–45 and 45–95%, respectively. In addition, the prepared E-skins were applied in the fields of intelligent robotics and wearable devices. Robotic intelligence and wireless health monitoring were successfully realized