7 research outputs found
Modulating the Reactivity of Functionalized <i>N</i>,<i>S</i>-Ketene Acetal in MCR: Selective Synthesis of Tetrahydropyridines and Thiochromeno[2,3-<i>b</i>]pyridines via DABCO-Catalyzed Tandem Annulation
An efficient and straightforward three-component synthetic
protocol
was developed to synthesize 1,2,3,4-tetrahydropyridine derivatives
or thiochromeno[2,3-<i>b</i>]pyridine derivatives from β-aroylthioacetanilides
or β-(2-haloaroyl)thioacetanilides, aldehydes, and aroyl acetonitriles
via DABCO-catalyzed tandem [3 + 2 + 1] annulation and S<sub>N</sub>Ar reaction. This synthetic approach has the prominent features of
high chemo-, stereo- (or enantio-), and unusual regioselectivity.
In the domino processes, at least seven reactive sites were involved,
and up to three covalent bonds and one functionalized pyridine ring
were generated. This facile and efficient reaction is a quite general
for the preparation of tetrahydropyridine derivatives or thiochromeno[2,3-<i>b</i>]pyridine derivatives
Modulating the Reactivity of Functionalized <i>N</i>,<i>S</i>-Ketene Acetal in MCR: Selective Synthesis of Tetrahydropyridines and Thiochromeno[2,3-<i>b</i>]pyridines via DABCO-Catalyzed Tandem Annulation
An efficient and straightforward three-component synthetic
protocol
was developed to synthesize 1,2,3,4-tetrahydropyridine derivatives
or thiochromeno[2,3-<i>b</i>]pyridine derivatives from β-aroylthioacetanilides
or β-(2-haloaroyl)thioacetanilides, aldehydes, and aroyl acetonitriles
via DABCO-catalyzed tandem [3 + 2 + 1] annulation and S<sub>N</sub>Ar reaction. This synthetic approach has the prominent features of
high chemo-, stereo- (or enantio-), and unusual regioselectivity.
In the domino processes, at least seven reactive sites were involved,
and up to three covalent bonds and one functionalized pyridine ring
were generated. This facile and efficient reaction is a quite general
for the preparation of tetrahydropyridine derivatives or thiochromeno[2,3-<i>b</i>]pyridine derivatives
Modulating the Reactivity of Functionalized <i>N</i>,<i>S</i>-Ketene Acetal in MCR: Selective Synthesis of Tetrahydropyridines and Thiochromeno[2,3-<i>b</i>]pyridines via DABCO-Catalyzed Tandem Annulation
An efficient and straightforward three-component synthetic
protocol
was developed to synthesize 1,2,3,4-tetrahydropyridine derivatives
or thiochromeno[2,3-<i>b</i>]pyridine derivatives from β-aroylthioacetanilides
or β-(2-haloaroyl)thioacetanilides, aldehydes, and aroyl acetonitriles
via DABCO-catalyzed tandem [3 + 2 + 1] annulation and S<sub>N</sub>Ar reaction. This synthetic approach has the prominent features of
high chemo-, stereo- (or enantio-), and unusual regioselectivity.
In the domino processes, at least seven reactive sites were involved,
and up to three covalent bonds and one functionalized pyridine ring
were generated. This facile and efficient reaction is a quite general
for the preparation of tetrahydropyridine derivatives or thiochromeno[2,3-<i>b</i>]pyridine derivatives
Inferred phylogenetic relationship among representative <i>Babesia</i> and <i>Theileria</i> species based on the combined data of 18S rDNA and RPS8 (coding and non-coding regions) gene sequences.
<p>The combined data of 18S rDNA and RPS8 (coding and non-coding regions) gene sequences were analyzed utilizing maximum likelihood (ML), using <i>Toxoplasma gondii</i> as outgroup. The numbers along branches indicate bootstrap probability (BP) values. The accession numbers of the isolates used in the phylogenetic tree were listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079860#pone-0079860-t001" target="_blank">Table 1</a>. High statistically supported nodes had BP≥85; while poorly statistically supported nodes had BP<60.</p
Inferred phylogenetic relationship among representative <i>Babesia</i> and <i>Theileria</i> species based on 18S rDNA sequences.
<p>The 18S rDNA sequences were analyzed utilizing Bayesian analysis (Bayes) and maximum likelihood (ML), using <i>Toxoplasma gondii</i> as outgroup. The numbers along branches indicate posterior probability (PP) and bootstrap probability (BP) values resulting from different analyses in the order: Bayes/ ML. Highly statistically supported nodes were BP≥85; PP≥0.98; while poorly statistically supported nodes were BP<60; PP<0.90.</p
The alignment of RPS8 (coding and non-coding regions) sequences from <i>B. bovis</i> and <i>Theileria</i> species.
<p><i>B. bovis</i> (GenBank accession no. JN400409); <i>B. microti</i> (GenBank accession no. FO082874); <i>T. annulata</i> (GenBank accession no. NC_011099); <i>B. bovis</i> (GenBank accession no. NW_001820855) were aligned using the ClustalW2 program. The non-coding region is marked with gray shading.</p
Inferred phylogenetic relationship among representative <i>Babesia</i> and <i>Theileria</i> species based on RPS8 (coding and non-coding regions) gene sequences.
<p>The RPS8 (coding and non-coding regions) gene sequences were analyzed utilizing Bayesian analysis (Bayes) and maximum likelihood (ML), using <i>Toxoplasma gondii</i> as outgroup. The numbers along branches indicate posterior probability (PP) and bootstrap probability (BP) values resulting from different analyses in the order: Bayes/ ML. The accession numbers of the isolates used in the phylogenetic tree were listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079860#pone-0079860-t001" target="_blank">Table 1</a>. High statistically supported nodes had BP≥85; PP≥0.98; while poorly statistically supported nodes had BP<60; PP<0.90.</p