7 research outputs found

    Liminal Surfaces

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    The poet Ben Okri wrote: ‚ÄúStories are the secret reservoir of values: change the stories individuals and nations live by and tell themselves, and you change the individuals and nations.‚ÄĚ (Stibbe) In the early 21st Century we are facing numerous environmental problems that are being caused by human activity. This era is termed the Anthropocene , a time when accumulated pollutants are causing detrimental ecological change. Ocean creatures are threatened by increasing seawater temperature, acidifying pH levels and melting ice. On land we are experiencing droughts, alteration of biomes, extinctions and an atmosphere that contains less oxygen per breath than it used to. I wondered how humanity had allowed this to happen. What tales have we told ourselves that led to this situation, and how might we devise new tales that might lead to a less polluted future? I see our environment as a structure of surfaces. Material surfaces on which we live, existential surfaces that enfold our thoughts, and liminal surfaces that transition awareness of these through experiential learning. I researched non-toxic printmaking techniques to attach images to surfaces, both physical and cognitive, as a way to bring about recognition that we are part of the natural world, and need to reconnect to it. if we are to begin to solve human-caused environmental damage. The textured surfaces and prints I created in my thesis work are intended to be visually compelling, yet unsettling. An audience for my work would need to articulate new language if they are to assimilate the educable moments it offers. The research presented here uses the concept of surface to unify information about language, cognition, biology and art history as they give context to my artwork about the Anthropocene. I present research that indicates humanity\u27s present difficulty is not a sudden occurrence. Rather, it is the continuance of centuries of behavior built on faulty assumptions derived from metaphorical language and imagery that gave rise to generational practices of acquisitiveness and economic expansion at the expense of the environment. I present a real-world consequence of our actions: the invention of plastic, useful in many ways, but like the sorcerer\u27s apprentice with too many water buckets, is now a profound danger to aquatic ecosystems

    Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u3b2, tau, immunity and lipid processing

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    Author Correction: Genetic meta-analysis of diagnosed Alzheimer‚Äôs disease identifies new risk loci and implicates Aő≤, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

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    An amendment to this paper has been published and can be accessed via a link at the top of the paper

    Author Correction: Genetic meta-analysis of diagnosed Alzheimer\u27s disease identifies new risk loci and implicates Aő≤, tau, immunity and lipid processing.

    No full text
    An amendment to this paper has been published and can be accessed via a link at the top of the paper

    Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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    Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease

    Author Correction: Genetic meta-analysis of diagnosed Alzheimer‚Äôs disease identifies new risk loci and implicates Aő≤, tau, immunity and lipid processing

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