8 research outputs found

    Elementary science textbooks : their contents, text characteristics, and comprehensibility : longitudinal study

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    Includes bibliographical references (leaves 21-24)Supported in part by a grant from the National Science Foundation, #NSFMDR85-50320, and in part by the National Institute of Education, #400-81-003

    Effects of home literacy on children's recall

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    Presented at annual meeting, American Educational Research Association, San Francisco, CA, Apr. 16-20, 1986.Includes bibliographical references (leaves 10-12)Research was carried out under NIE grant no. NIE 400-81-003

    Are first grade basal reading programs really all that much alike? : an analysis of the labyrinth of instructional approaches to decoding, comprehension, and story text comprehensibility in four programs : longitudinal study

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    Running title: First grade reading programs.Includes bibliographical references (leaves 39-41)Performed pursuant to contract no. 400-81-0030 of the National Institute of Educatio

    Mapping the human genetic architecture of COVID-19

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    The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
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