Hadronization via Coalescence

We review the quark coalescence model for hadronization in relativistic heavy ion collisions and show how it can explain the observed large baryon to meson ratio at intermediate transverse momentum and scaling of the elliptic flows of identified hadrons. We also show its predictions on higher-order anisotropic flows and discuss how quark coalescence applied to open- and hidden-charm mesons can give insight to charm quark interactions in the quark-gluon plasma and $J/\Psi$ production in heavy ion collisions.Comment: 6 pages, 4 figures, Proceedings of 20th Winter Workshop on Nuclear Dynamics, Trelawny Beach, Jamaica, March 15--20, 200

Safe discontinuation of nilotinib in a patient with chronic myeloid leukemia: a case report

Case presentation. We report the case of a 64-year-old Caucasian man diagnosed with chronic-phase chronic myeloid leukemia in April 2005. After 4 years of treatment with imatinib, he became intolerant to the drug and was switched to nilotinib. Two years later, he decided to stop nilotinib. Undetectable molecular response persisted for 30 months after discontinuation of the drug. Introduction. Although there is a considerable amount of data in the literature on safe discontinuation of first-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia, little is known about discontinuation of second-generation tyrosine kinase inhibitor therapy. Most previous studies have been focused on dasatinib, and the few cases of nilotinib withdrawal that have been reported had a median follow-up of 12 months. To the best of our knowledge, the present report is the first to describe nilotinib withdrawal with 30 months of follow-up. Conclusion: Our present case suggests that nilotinib withdrawal is safe for patients with chronic myeloid leukemia who achieve a stable undetectable molecular response. Our patient was homozygous for killer immunoglobulin-like receptor haplotype A, previously reported to be a promising immunogenetic marker for undetectable molecular response. We recommend additional studies to investigate patient immunogenetic profiles and their potential role in complete response to therap

Scalings of Elliptic Flow for a Fluid at Finite Shear Viscosity

Within a parton cascade approach we investigate the scaling of the differential elliptic flow $v_2(p_T)$ with eccentricity $\epsilon_x$ and system size and its sensitivity to finite shear viscosity. We present calculations for shear viscosity to entropy density ratio $\eta/s$ in the range from $1/4\pi$ up to $1/\pi$, finding that the $v_2$ saturation value varies by about a factor 2. Scaling of $v_2(p_T)/\epsilon_x$ is seen also for finite $\eta/s$ which indicates that it does not prove a perfect hydrodynamical behavior, but is compatible with a plasma at finite $\eta/s$. Introducing a suitable freeze-out condition, we see a significant reduction of $v_2(p_T)$ especially at intermediate $p_T$ and for more peripheral collisions. This causes a breaking of the scaling for both $v_2(p_T)$ and the $p_T-$averaged $v_2$, while keeping the scaling of v_2(p_T)/\la v_2\ra. This is in better agreement with the experimental observations and shows as a first indication that the $\eta/s$ should be significantly lower than the pQCD estimates. We finally point out the necessity to include the hadronization via coalescence for a definite evaluation of $\eta/s$ from intermediate $p_T$ data.Comment: 5 pages, 5 figures. Two points in fig.4 has been change

Transport properties of isospin effective mass splitting

We investigate in detail the momentum dependence ($MD$) of the effective in medium Nucleon-Nucleon ($NN$) interaction in the isovector channel. We focus the discussion on transport properties of the expected neutron-proton ($n/p$) effective mass splitting at high isospin density. We look at observable effects from collective flows in Heavy Ion Collisions ($HIC$) of charge asymmetric nuclei at intermediate energies. Using microscopic kinetic equation simulations nucleon transverse and elliptic collective flows in $Au+Au$ collisions are evaluated. In spite of the reduced charge asymmetry of the interacting system interesting $isospin-MD$ effects are revealed. Good observables, particularly sensitive to the $n/p$-mass splitting, appear to be the differences between neutron and proton flows. The importance of more exclusive measurements, with a selection of different bins of the transverse momenta ($p_t$) of the emitted particles, is stressed. In more inclusive data a compensation can be expected from different $p_t$-contributions, due to the microscopic $isospin-MD$ structure of the nuclear mean field in asymmetric matter.Comment: 18 pages, 11 figure

Reaction Dynamics with Exotic Beams

We review the new possibilities offered by the reaction dynamics of asymmetric heavy ion collisions, using stable and unstable beams. We show that it represents a rather unique tool to probe regions of highly Asymmetric Nuclear Matter ($ANM$) in compressed as well as dilute phases, and to test the in-medium isovector interaction for high momentum nucleons. The focus is on a detailed study of the symmetry term of the nuclear Equation of State ($EOS$) in regions far away from saturation conditions but always under laboratory controlled conditions. Thermodynamic properties of $ANM$ are surveyed starting from nonrelativistic and relativistic effective interactions. In the relativistic case the role of the isovector scalar $\delta$-meson is stressed. The qualitative new features of the liquid-gas phase transition, "diffusive" instability and isospin distillation, are discussed. The results of ab-initio simulations of n-rich, n-poor, heavy ion collisions, using stochastic isospin dependent transport equations, are analysed as a function of beam energy and centrality. The isospin dynamics plays an important role in all steps of the reaction, from prompt nucleon emissions to the final fragments. The isospin diffusion is also of large interest, due to the interplay of asymmetry and density gradients. In relativistic collisions, the possibility of a direct study of the covariant structure of the effective nucleon interaction is shown. Results are discussed for particle production, collective flows and iso-transparency. Perspectives of further developments of the field, in theory as well as in experiment, are presented.Comment: 167+5 pages, 77 figures, general revie

Isospin in fragment production

Based on a general approach to binary systems we show that in the low density region asymmetric nuclear matter (ANM) is unstable only against isoscalarlike fluctuations. The physical meaning of the thermodynamical chemical and mechanical instabilities is related to the inequality relations verified by the strength of interaction among different components. Relevance of these results in bulk and neck fragmentation is discussed.Comment: 8 pages, 5 Postscript figures, talk at Cortona 2002 Conference, Oct.7-Oct.12, Italy, World Scientific (in press