380 research outputs found

    The antecedents of modernization in African geography.

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    Dept. of Geography. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1983 .G736. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.A.)--University of Windsor (Canada), 1983

    A willingness to pay for maintenance and operation of rural DWS schemes

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    Improved planning methodology is sought for sustainable and replicable rural water schemes. Improved methodology should have a mechanism to recover the necessary resources for operation and maintenance costs from water users. This paper analyses the differences between the users’ willingness to pay in rural markets and village DWS schemes of Nepal based on information collected through a questionnaire survey of 205 households and institutional survey of 12 DWS water user committees. Due to different socio-economic scenarios among rural villages and rural market centres, core problems in management and operation of their DWS schemes are immensely different. Weak institutional capability is the prime problem in rural village DWS schemes. On the contrary, technicalities such as insufficient water quantity and inconvenient locations of water points are the major problems in rural market centres. Moreover, users’ satisfaction level is influential for operation and maintenance of both rural DWS schemes

    Low significance of evidence for black hole echoes in gravitational wave data

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    Recent detections of merging black holes allow observational tests of the nature of these objects. In some proposed models, non-trivial structure at or near the black hole horizon could lead to echo signals in gravitational wave data. Recently, Abedi et al. claimed tentative evidence for repeating damped echo signals following the gravitational-wave signals of the binary black hole merger events recorded in the first observational period of the Advanced LIGO interferometers. We reanalyse the same data, addressing some of the shortcomings of their method using more background data and a modified procedure. We find a reduced statistical significance for the claims of evidence for echoes, calculating increased p-values for the null hypothesis of echo-free noise. The reduced significance is entirely consistent with noise, and so we conclude that the analysis of Abedi et al. does not provide any observational evidence for the existence of Planck-scale structure at black hole horizons.Comment: As accepted by Physical Review

    What is the impact of long-term COVID-19 on workers in healthcare settings? A rapid systematic review of current evidence.

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    Long COVID is a devastating, long-term, debilitating illness which disproportionately affects healthcare workers, due to the nature of their work. There is currently limited evidence specific to healthcare workers about the experience of living with Long COVID, or its prevalence, pattern of recovery or impact on healthcare. Our objective was to assess the effects of Long COVID among healthcare workers and its impact on health status, working lives, personal circumstances, and use of health service resources. We conducted a systematic rapid review according to current methodological standards and reported it in adherence to the PRISMA 2020 and ENTREQ statements. We searched relevant electronic databases and identified 3770 articles of which two studies providing qualitative evidence and 28 survey studies providing quantitative evidence were eligible. Thematic analysis of the two qualitative studies identified five themes: uncertainty about symptoms, difficulty accessing services, importance of being listened to and supported, patient versus professional identity and suggestions to improve communication and services for people with Long COVID. Common long-term symptoms in the survey studies included fatigue, headache, loss of taste and/or smell, breathlessness, dyspnoea, difficulty concentrating, depression and anxiety. Healthcare workers struggled with their dual identity (patient/doctor) and felt dismissed or not taken seriously by their doctors. Our findings are in line with those in the literature showing that there are barriers to healthcare professionals accessing healthcare and highlighting the challenges of receiving care due to their professional role. A more representative approach in Long COVID research is needed to reflect the diverse nature of healthcare staff and their occupations. This rapid review was conducted using robust methods with the codicil that the pace of research into Long COVID may mean relevant evidence was not identifie

    A genome-wide association study of self-rated health

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    Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs

    Architecture of the major component of the type III secretion system export apparatus

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    Type III secretion systems (T3SSs) are bacterial membrane–embedded nanomachines designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion through T3SS is governed by a subset of inner membrane proteins termed the 'export apparatus'. We show that a key member of the Shigella flexneri export apparatus, MxiA, assembles into a ring essential for secretion in vivo. The ring-forming interfaces are well-conserved in both nonflagellar and flagellar homologs, implying that the ring is an evolutionarily conserved feature in these systems. Electron cryo-tomography revealed a T3SS-associated cytoplasmic torus of size and shape corresponding to those of the MxiA ring aligned to the secretion channel located between the secretion pore and the ATPase complex. This defines the molecular architecture of the dominant component of the export apparatus and allows us to propose a model for the molecular mechanisms controlling secretion
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