2,623 research outputs found
Leveraging OpenStack and Ceph for a Controlled-Access Data Cloud
While traditional HPC has and continues to satisfy most workflows, a new
generation of researchers has emerged looking for sophisticated, scalable,
on-demand, and self-service control of compute infrastructure in a cloud-like
environment. Many also seek safe harbors to operate on or store sensitive
and/or controlled-access data in a high capacity environment.
To cater to these modern users, the Minnesota Supercomputing Institute
designed and deployed Stratus, a locally-hosted cloud environment powered by
the OpenStack platform, and backed by Ceph storage. The subscription-based
service complements existing HPC systems by satisfying the following unmet
needs of our users: a) on-demand availability of compute resources, b)
long-running jobs (i.e., days), c) container-based computing with
Docker, and d) adequate security controls to comply with controlled-access data
requirements.
This document provides an in-depth look at the design of Stratus with respect
to security and compliance with the NIH's controlled-access data policy.
Emphasis is placed on lessons learned while integrating OpenStack and Ceph
features into a so-called "walled garden", and how those technologies
influenced the security design. Many features of Stratus, including tiered
secure storage with the introduction of a controlled-access data "cache",
fault-tolerant live-migrations, and fully integrated two-factor authentication,
depend on recent OpenStack and Ceph features.Comment: 7 pages, 5 figures, PEARC '18: Practice and Experience in Advanced
Research Computing, July 22--26, 2018, Pittsburgh, PA, US
How Prosecutors and Defense Attorneys Differ in Their Use of Neuroscience Evidence
Much of the public debate surrounding the intersection of neuroscience and criminal law is based on assumptions about how prosecutors and defense attorneys differ in their use of neuroscience evidence. For example, according to some commentators, the defense’s use of neuroscience evidence will abdicate criminals of all responsibility for their offenses. In contrast, the prosecution’s use of that same evidence will unfairly punish the most vulnerable defendants as unfixable future dangers to society. This “double- edged sword” view of neuroscience evidence is important for flagging concerns about the law’s construction of criminal responsibility and punishment: it demonstrates that the same information about the defendant can either be mitigating or aggravating depending on who is raising it. Yet empirical assessments of legal decisions reveal a far more nuanced reality, showing that public beliefs about the impact of neuroscience on the criminal law can often be wrong. This Article takes an evidence-based and multidisciplinary approach to examining how courts respond to neuroscience evidence in capital cases when the defense presents it to argue that the defendant’s mental state at the time of the crime was below the given legal requisite due to some neurologic or cognitive deficiency
ANAC017 coordinates organellar functions and stress responses by reprogramming retrograde signaling
Mitochondria adjust their activities in response to external and internal stimuli to optimize growth via the mitochondrial retrograde response (MRR) signaling pathway. The Arabidopsis (Arabidopsis thaliana) NAC domain transcription factor ANAC017 has previously been identified as a regulator of the MRR. We show here that overexpression of ANAC017 in Arabidopsis leads to growth retardation, altered leaf development with decreased cell size and viability, and early leaf senescence. RNA-seq analyses revealed increased ANAC017 expression leads to higher expression of genes related to mitochondrial stress, cell death/autophagy, and leaf senescence under non-limiting growth conditions, as well as extensive repression of chloroplast function. Gene regulatory network analysis indicated that a complex hierarchy of transcription factors exists downstream of ANAC017. These involve a set of up-regulated ANAC and WRKY transcription factors associated with organellar signaling and senescence. The network also includes a number of ethylene- and gibberellic acid-related transcription factors with established function in stress responses and growth regulation, which down-regulate their target genes. A number of BASIC LEUCINE-ZIPPER MOTIF transcription factors involved in the endoplasmic reticulum unfolded protein response or balancing of energy homeostasis via the SNF1-RELATED PROTEIN KINASE1 were also down-regulated by ANAC017 overexpression. Our results show that the endoplasmic reticulum membrane-tethering of the constitutively expressed ANAC017, and its controlled release, are crucial to fine-tune a fast reactive but potentially harmful signaling cascade. Thus, ANAC017 is a master regulator of cellular responses with mitochondria acting as central sensors
Shared semantics : exploring the interface between human and chimpanzee gestural communication
Career development grant, University ofOslo (PI: Patel-Grosz); EU Horizon 2020Marie Skłodowska-Curie R&I Program,Grant/Award Number: 945408 (Recipient:Patel-Grosz); H2020 European ResearchCouncil, Grant/Award Number: 802719(PI: Hobaiter); RFIEA+LABEX,Grant/Award Number: ANR-11-LABX-0027-01 (Recipient: Patel-Grosz)Striking similarities across ape gestural repertoires suggest shared phylogenetic origins that likely provided a foundation for the emergence of language. We pilot a novel approach for exploring possible semantic universals across human and nonhuman ape species. In a forced-choice task, n = 300 participants watched 10 chimpanzee gesture forms performed by a human and chose from responses that paralleled inferred meanings for chimpanzee gestures. Participants agreed on a single meaning for nine gesture forms; in six of these the agreed form-meaning pair response(s) matched those established for chimpanzees. Such shared understanding suggests apes' (including humans') gesturing shares deep evolutionary origins.Peer reviewe
Multi-lepton signals from the top-prime quark at the LHC
We analyze the collider signatures of models with a vector-like top-prime
quark and a massive color-octet boson. The top-prime quark mixes with the top
quark in the Standard Model, leading to richer final states than ones that are
investigated by experimental collaborations. We discuss the multi-lepton final
states, and show that they can provide increased sensitivity to models with a
top-prime quark and gluon-prime. Searches for new physics in high multiplicity
events are an important component of the LHC program and complementary to
analyses that have been performed.Comment: 7 pages, 4 figures, 2 table
Apraxia and motor dysfunction in corticobasal syndrome
Background: Corticobasal syndrome (CBS) is characterized by multifaceted motor system dysfunction and cognitive disturbance; distinctive clinical features include limb apraxia and visuospatial dysfunction. Transcranial magnetic stimulation (TMS) has been used to study motor system dysfunction in CBS, but the relationship of TMS parameters to clinical features has not been studied. The present study explored several hypotheses; firstly, that limb apraxia may be partly due to visuospatial impairment in CBS. Secondly, that motor system dysfunction can be demonstrated in CBS, using threshold-tracking TMS, and is linked to limb apraxia. Finally, that atrophy of the primary motor cortex, studied using voxel-based morphometry analysis (VBM), is associated with motor system dysfunction and limb apraxia in CBS. Â Methods: Imitation of meaningful and meaningless hand gestures was graded to assess limb apraxia, while cognitive performance was assessed using the Addenbrooke's Cognitive Examination - Revised (ACE-R), with particular emphasis placed on the visuospatial subtask. Patients underwent TMS, to assess cortical function, and VBM. Â Results: In total, 17 patients with CBS (7 male, 10 female; mean age 64.4+/2 6.6 years) were studied and compared to 17 matched control subjects. Of the CBS patients, 23.5% had a relatively inexcitable motor cortex, with evidence of cortical dysfunction in the remaining 76.5% patients. Reduced resting motor threshold, and visuospatial performance, correlated with limb apraxia. Patients with a resting motor threshold <50% performed significantly worse on the visuospatial sub-task of the ACE-R than other CBS patients. Cortical function correlated with atrophy of the primary and pre-motor cortices, and the thalamus, while apraxia correlated with atrophy of the pre-motor and parietal cortices. Â Conclusions: Cortical dysfunction appears to underlie the core clinical features of CBS, and is associated with atrophy of the primary motor and pre-motor cortices, as well as the thalamus, while apraxia correlates with pre-motor and parietal atrophy
Holding and restraining children for clinical procedures within an acute care setting: an ethical consideration of the evidence
This critical reflection on the ethical concerns of current practice is underpinned by a systematic synthesis of current evidence focusing on why and how children are held or restrained for clinical procedures within acute care and the experiences of those present when a child is held against their wishes. Empirical evidence from a range of clinical settings internationally demonstrates that frequently children are held for procedures to be completed; younger children and those requiring procedures perceived as urgent are more likely to be held. Parents and health professionals express how holding children for procedures can cause feelings of moral distress expressed as uncertainty, guilt and upset and that this act breaches the trusting and protective relationship established with children. Despite this, children’s rights and alternatives to holding are not always respected or explored. Children’s experiences and perceptions are absent from current literature.
Children and young people have a moral right to have their voice and protests heard and respected and for these to inform judgements of their best interests and the actions of health professionals. Without robust evidence, debate and recognition that children are frequently held against their wishes in clinical practice for procedures which may not be urgent, children’s rights will continue to be compromised
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