Resummed prediction for Higgs boson production through bbˉb\bar{b} annihilation at N3^3LL

We present an accurate theoretical prediction for the production of Higgs boson through bottom quark annihilation at the LHC up to next-to-next-to-next-to leading order (N$^3$LO) plus next-to-next-to-next-to-leading logarithmic (N$^3$LL) accuracy. We determine the third order perturbative Quantum Chromodynamics (QCD) correction to the process dependent constant in the resummed expression using the three loop bottom quark form factor and third order quark soft distribution function. Thanks to the recent computation of N$^3$LO corrections to this production cross-section from all the partonic channels, an accurate matching can be obtained for a consistent predictions at N$^3$LO+N$^3$LL accuracy in QCD. We have studied in detail the impact of resummed threshold contributions to inclusive cross-sections at various centre-of-mass energies and also discussed their sensitivity to renormalization and factorization scales at next-to-next-to leading order (NNLO) matched with next-to-next-to leading logarithm (NNLL). At N$^3$LO+N$^3$LL, we predict the cross-section for different centre-of-mass energies using the recently available results in \cite{Duhr:2019kwi} as well as study the renormalization scale dependence at the same order.Comment: 19 pages, 4 figures, 2 table

Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms

Angiogenesis is the hallmark of cancer, and development of aggressiveness of primary tumor depends on de novo angiogenesis. Here, using multiple in vitro and in vivo models, we report that osteopontin (OPN) triggers vascular endothelial growth factor (VEGF)-dependent tumor progression and angiogenesis by activating breast tumor kinase (Brk)/nuclear factor-inducing kinase/nuclear factor-κB (NF-κB)/activating transcription factor-4 (ATF-4) signaling cascades through autocrine and paracrine mechanisms in breast cancer system. Our results revealed that both exogenous and tumor-derived OPN play significant roles in VEGF-dependent tumor angiogenesis. Clinical specimen analysis showed that OPN and VEGF expressions correlate with levels of neuropilin-1, Brk, NF-κB, and ATF-4 in different grades of breast cancer. Consequently, OPN plays essential role in two key aspects of tumor progression: VEGF expression by tumor cells and VEGF-stimulated neovascularization. Thus, targeting OPN and its regulated signaling network could be a novel strategy to block tumor angiogenesis and may develop an effective therapeutic approach for the management of breast cancer

The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C α/c-Src/IκB Kinase α/β-dependent prostate tumor progression and angiogenesis

The regulation of tumor progression towards its malignancy needs the interplay among several cytokines, growth factors, and enzymes, which are controlled in the tumor microenvironment. Here, we report that osteopontin, a small integrin-binding ligand N-linked glycoprotein family of calcified extracellular matrix-associated protein, regulates prostate tumor growth by regulating the expression of cyclooxygenase-2 (COX-2). We have shown that osteopontin stimulates the activation of protein kinase C a/nuclear factor-inducing kinase/nuclear factor-κB-dependent signaling cascades that induces COX-2 expression, which in turn regulates the prostaglandin E2 production, matrix metalloproteinase-2 activation, and tumor progression and angiogenesis. We have revealed that suppression of osteopontin-induced COX-2 expression by the nonsteroidal anti-inflammatory drug celecoxib or blocking the EP2 receptor by its blocking antibody resulted in significant inhibition of cell motility and tumor growth and angiogenesis. The data also showed that osteopontin-induced mice PC-3 xenograft exhibits higher tumor load, increased tumor cell infiltration, nuclear polymorphism, and neovascularization. Interestingly, use of celecoxib or anti-EP2 blocking antibody drastically suppressed osteopontin-induced tumor growth that further indicated that suppression of COX-2 or its metabolites could significantly inhibit osteopontin-induced tumor growth. Human clinical prostate cancer specimen analysis also supports our in vitro and animal model studies. Our findings suggest that blockage of osteopontin and/or COX-2 is a promising therapeutic approach for the inhibition of prostate tumor progression and angiogenesis

A Real-Time Angle- and Illumination-Aware Face Recognition System Based on Artificial Neural Network

Automatic authentication systems, using biometric technology, are becoming increasingly important with the increased need for person verification in our daily life. A few years back, fingerprint verification was done only in criminal investigations. Now fingerprints and face images are widely used in bank tellers, airports, and building entrances. Face images are easy to obtain, but successful recognition depends on proper orientation and illumination of the image, compared to the one taken at registration time. Facial features heavily change with illumination and orientation angle, leading to increased false rejection as well as false acceptance. Registering face images for all possible angles and illumination is impossible. In this work, we proposed a memory efficient way to register (store) multiple angle and changing illumination face image data, and a computationally efficient authentication technique, using multilayer perceptron (MLP). Though MLP is trained using a few registered images with different orientation, due to generalization property of MLP, interpolation of features for intermediate orientation angles was possible. The algorithm is further extended to include illumination robust authentication system. Results of extensive experiments verify the effectiveness of the proposed algorithm

Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis

Hypoxia is a key parameter that controls tumor angiogenesis and malignant progression by regulating the expression of several oncogenic molecules. The nonreceptor protein-tyrosine kinases Syk and Lck play crucial roles in the signaling mechanism of various cellular processes. The enhanced expression of Syk in normal breast tissue but not in malignant breast carcinoma has prompted us to investigate its potential role in mammary carcinogenesis. Accordingly, we hypothesized that hypoxia/reoxygenation (H/R) may play an important role in regulating Syk activation, and Lck may be involved in this process. In this study, we have demonstrated that H/R differentially regulates Syk phosphorylation and its subsequent interaction and cross-talk with Lck in MCF-7 cells. Moreover, Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM), urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor (VEGF) in response to H/R. Overexpression of wild type Syk inhibited the H/R-induced uPA, MMP-9, and VEGF expression but up-regulated MelCAM expression. Our data also indicated that MelCAM acts as a tumor suppressor by negatively regulating H/R-induced uPA secretion and MMP-9 activation. The mice xenograft study showed the cross-talk between Syk and Lck regulated H/R-induced breast tumor progression and further correlated with the expressions of MelCAM, uPA, MMP-9, and VEGF. Human clinical specimen analysis supported the in vitro and in vivo findings. To our knowledge, this is first report that the cross-talk between Syk and Lck regulates H/R-induced breast cancer progression and further suggests that Syk may act as potential therapeutic target for the treatment of breast cancer

Dynamical analysis of interacting non-canonical scalar field model

In this work, considering the background dynamics of flat Friedmann-Lemaitre-Robertson-Walker(FLRW) model of the universe, we investigate a non-canonical scalar field model as dark energy candidate which interacting with the pressureless dust as dark matter in view of dynamical systems analysis. Two interactions from phenomenological point of view are chosen: one is depending on Hubble parameter $H$, another is local, independent of Hubble parameter. In Interaction model 1, an inverse square form of potential as well as coupling function associated with scalar field is chosen and a two dimensional autonomous system is obtained. From the 2D autonomous system, we obtain scalar field dominated solutions representing late time accelerated evolution of the universe. Late time scaling solutions are also realized by the accelerated evolution of the universe attracted in quintessence era. Center Manifold Theory can provide the sufficient conditions on model parameters such that the de Sitter like solutions can be stable attractor at late time in this model. In the Interaction model 2, potential as well as coupling function are considered to be evolved exponentially on scalar field and as a result of which a four dimensional autonomous system is achieved. From the analysis of 4D system, we obtain non-hyperbolic sets of critical points which are analyzed by the Center Manifold Theory. In this model, de Sitter like solutions represent the transient evolution of the universe.Comment: 25 pages, 14 captioned figures and 2 Table