Synthesis and characterization of (S)-BINOL-modified cyclotriphosphazene tetradentate ligands

<p>Three novel cyclotriphosphazene derivatives were synthesized by the reaction of hexachlorocyclotriphosphazene (HCCP) with (S)-BINOL and the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride. The bromination reaction was carried out using PBr₃ to give N₃P₃(O₂C₂₀H₁₂)(OC₆H₄-p-CH₂Br)₄ (3). The target ligands were obtained by the reaction of compound 3 with morpholine, imidazole, and pyrazole, respectively. Structure of title compounds were characterized by ¹H NMR, ¹³C NMR, ³¹P NMR, and ESI-MS. The Cu complex of 4 was effective in the cleavage of pUC19 DNA under physiological conditions.</p

Highly Chemoselective Synthesis of Novel 6-<i>O</i>-phosphorylated 6-Hydroxypyridazine-3(2H)-one

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