5 research outputs found
Nucleophilic Phosphine-Catalyzed Intramolecular Michael Reactions of <i>N</i>‑Allylic Substituted α‑Amino Nitriles: Construction of Functionalized Pyrrolidine Rings via 5-<i>endo</i>-trig Cyclizations
Pyrrolidine
rings are common moieties for pharmaceutical candidates
and natural compounds, and the construction of these skeletons has
received much attention. α-Amino nitriles are versatile intermediates
in synthetic chemistry and have been widely used in the generation
of multiple polyfunctional structures. Herein, a novel nucleophilic
phosphine-catalyzed intramolecular Michael reaction of <i>N</i>-allylic substituted α-amino nitriles has been developed for
the efficient construction of functionalized 2,4-disubstituted pyrrolidines
(<i>N</i>-heterocyclic α-amino nitriles) via 5-<i>endo</i>-trig cyclization. Furthermore, the one-pot sequence
of the synthesis of pyrrolidine and the subsequent transformations
of the functionalized products have also been demonstrated
Asymmetric Construction of Functionalized 1,2-Dihydropyridine and Pyridine Derivatives with Adjacent Stereocenters via a Unified Metal-Free Catalytic Approach
A novel asymmetric catalytic approach
for the construction of enantioenriched
functionalized 1,2-dihydropyridines and pyridine derivatives incorporating
adjacent quaternary and tertiary stereocenters has been reported.
This process involved a metal-free catalytic asymmetric allylic alkylation
and a stereospecifically nonoxidative aromatization approach for the
desired chiral molecules
Asymmetric Construction of Functionalized 1,2-Dihydropyridine and Pyridine Derivatives with Adjacent Stereocenters via a Unified Metal-Free Catalytic Approach
A novel asymmetric catalytic approach
for the construction of enantioenriched
functionalized 1,2-dihydropyridines and pyridine derivatives incorporating
adjacent quaternary and tertiary stereocenters has been reported.
This process involved a metal-free catalytic asymmetric allylic alkylation
and a stereospecifically nonoxidative aromatization approach for the
desired chiral molecules
Asymmetric Construction of Functionalized 1,2-Dihydropyridine and Pyridine Derivatives with Adjacent Stereocenters via a Unified Metal-Free Catalytic Approach
A novel asymmetric catalytic approach
for the construction of enantioenriched
functionalized 1,2-dihydropyridines and pyridine derivatives incorporating
adjacent quaternary and tertiary stereocenters has been reported.
This process involved a metal-free catalytic asymmetric allylic alkylation
and a stereospecifically nonoxidative aromatization approach for the
desired chiral molecules
Asymmetric Construction of Functionalized 1,2-Dihydropyridine and Pyridine Derivatives with Adjacent Stereocenters via a Unified Metal-Free Catalytic Approach
A novel asymmetric catalytic approach
for the construction of enantioenriched
functionalized 1,2-dihydropyridines and pyridine derivatives incorporating
adjacent quaternary and tertiary stereocenters has been reported.
This process involved a metal-free catalytic asymmetric allylic alkylation
and a stereospecifically nonoxidative aromatization approach for the
desired chiral molecules