11 research outputs found

    Systems Analysis of miRNA Biomarkers to Inform Drug Safety

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    microRNAs (miRNAs or miRs) are short non-coding RNA molecules which have been shown to be dysregulated and released into the extracellular milieu as a result of many drug and non-drug-induced pathologies in different organ systems. Consequently, circulating miRs have been proposed as useful biomarkers of many disease states, including drug-induced tissue injury. miRs have shown potential to support or even replace the existing traditional biomarkers of drug-induced toxicity in terms of sensitivity and specificity, and there is some evidence for their improved diagnostic and prognostic value. However, several pre-analytical and analytical challenges, mainly associated with assay standardization, require solutions before circulating miRs can be successfully translated into the clinic. This review will consider the value and potential for the use of circulating miRs in drug-safety assessment and describe a systems approach to the analysis of the miRNAome in the discovery setting, as well as highlighting standardization issues that at this stage prevent their clinical use as biomarkers. Highlighting these challenges will hopefully drive future research into finding appropriate solutions, and eventually circulating miRs may be translated to the clinic where their undoubted biomarker potential can be used to benefit patients in rapid, easy to use, point-of-care test systems

    Negotiating the boundaries to student engagement: the national student Learning and Teaching Network perspective

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    The Student Learning and Teaching Network is an informal community of students who are actively engaged in learning and teaching projects across the UK. It is coordinated by a committee of volunteers, originally from Centres for Excellence in Teaching and Learning (CETL), who have been working together since March 2006 to offer a variety of activities, events and online communities. As a network we have sought to challenge perceptions of students as passive consumers by promoting and empowering students as valid and active members of learning communities. Our members include course reps, peer and staff mentors, student interns, student researchers, students involved in designing learning spaces and student union officers. This session will provide an opportunity to hear from committee members about their experiences challenging the boundaries of student engagement within three distinct learning and teaching projects across UK institutions

    Cord and childhood 25(OH)D levels and total healthcare utilisation in the first three years of life.Adjusted correlation (Beta coefficient, β) between 25(OH) vitamin D levels measured at A) Birth and total healthcare utilization at age three years B) Age three years and total health care utilization by age three years.

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    <p>Cord and childhood 25(OH)D levels and total healthcare utilisation in the first three years of life.Adjusted correlation (Beta coefficient, β) between 25(OH) vitamin D levels measured at A) Birth and total healthcare utilization at age three years B) Age three years and total health care utilization by age three years.</p

    Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop

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    Human pluripotent stem cells (hPSCs) have the potential to transform medicine. However, hurdles remain to ensure safety for such cellular products. Science-based understanding of the requirements for source materials is required as are appropriate materials. Leaders in hPSC biology, clinical translation, biomanufacturing and regulatory issues were brought together to define requirements for source materials for the production of hPSC-derived therapies and to identify other key issues for the safety of cell therapy products. While the focus of this meeting was on hPSC-derived cell therapies, many of the issues are generic to all cell-based medicines. The intent of this report is to summarize the key issues discussed and record the consensus reached on each of these by the expert delegates

    Noninvasive Brain Stimulation to Modulate Neuroplasticity in Traumatic Brain Injury

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