The Changing Association Between Prenatal Participation in WIC and Birth Outcomes in New York City

We analyze the relationship between prenatal WIC participation and birth outcomes in New York City from 1988-2001. The analysis is unique for several reasons. First, we restrict the analysis to women on Medicaid and or WIC who have no previous live births and who initiate prenatal care within the first four months of pregnancy. Our goal is to lessen heterogeneity between WIC and non-WIC participants by limiting the sample to women who initiate prenatal care early and who have no experience with WIC from a previous pregnancy. Second, we focus on measures of fetal growth distinct from preterm birth, since there is little clinical support for a link between nutritional supplementation and premature delivery. Third, we analyze a large sub-sample of twin deliveries. Multifetal pregnancies increase the risk of anemia and fetal growth retardation and thus, may benefit more than singletons from nutritional supplementation. We find no relationship between prenatal WIC participation and measures of fetal growth except among a sub-sample of US-born Blacks between 1990-1992. A similarly sporadic pattern of association exists among US-born Black twins. Our finding that the modest association between WIC and fetal growth is limited to a specific racial and ethnic group during specific years and even specific ages suggests that the protective effect of prenatal WIC on adverse birth outcomes in New York City has been minimal.

Association of Air Pollution with Increased Incidence of Ventricular Tachyarrhythmias Recorded by Implanted Cardioverter Defibrillators

Epidemiologic studies have demonstrated a consistent link between sudden cardiac deaths and particulate air pollution. We used implanted cardioverter defibrillator (ICD) records of ventricular tachyarrhythmias to assess the role of air pollution as a trigger of these potentially life-threatening events. The study cohort consisted of 203 cardiac patients with ICD devices in the Boston metropolitan area who were followed for an average of 3.1 years between 1995 and 2002. Fine particle mass and gaseous air pollution plus temperature and relative humidity were measured on almost all days, and black carbon, sulfate, and particle number on a subset of days. Date, time, and intracardiac electrograms of ICD-detected arrhythmias were downloaded at the patients’ regular follow-up visits (about every 3 months). Ventricular tachyarrhythmias were identified by electrophysiologist review. Risk of ventricular arrhythmias associated with air pollution was estimated with logistic regression, adjusting for season, temperature, relative humidity, day of the week, patient, and a recent prior arrhythmia. We found increased risks of ventricular arrhythmias associated with 2-day mean exposure for all air pollutants considered, although these associations were not statistically significant. We found statistically significant associations between air pollution and ventricular arrhythmias for episodes within 3 days of a previous arrhythmia. The associations of ventricular tachyarrhythmias with fine particle mass, carbon monoxide, nitrogen dioxide, and black carbon suggest a link with motor vehicle pollutants. The associations with sulfate suggest a link with stationary fossil fuel combustion sources

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA).

BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes.MethodsWe estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva. We identified individual CpGs associated with residential-proximity-to-roadways at birth using robust linear regression [[Formula: see text]]. We also estimated association between proximity-to-roadways at birth and methylation of the same sites in blood samples collected at age 7-11 y ([Formula: see text]). We ran the same analyses in the Generation R Study for replication ([Formula: see text]). In Project Viva, we investigated associations of differential methylation at birth with midchildhood cognition using linear regression.ResultsLiving closer to major roadways at birth was associated with higher cord blood (and-more weakly-midchildhood blood) methylation of four sites in LAMB2. For each halving of residential-proximity-to-major-roadways, we observed a 0.82% increase in DNA methylation at cg05654765 [95% confidence interval (CI): (0.54%, 1.10%)], 0.88% at cg14099457 [95% CI: (0.56%, 1.19%)], 0.19% at cg03732535 [95% CI: (0.11%, 0.28)], and 1.08% at cg02954987 [95% CI: (0.65%, 1.51%)]. Higher cord blood methylation of these sites was associated with lower midchildhood nonverbal cognitive scores. Our results did not replicate in the Generation R Study.ConclusionsOur discovery results must be interpreted with caution, given that they were not replicated in a separate cohort. However, living close to major roadways at birth was associated with cord blood methylation of sites in LAMB2-a gene known to be linked to axonal development-in our U.S. cohort. Higher methylation of these sites associated with lower nonverbal cognitive scores at age 7-11 y in the same children. https://doi.org/10.1289/EHP2034

Use of and disparities in access to adaptive devices among U.S. adults with age-related eye diseases

This paper examines adaptive device use among two samples of U.S. adults aged 40 years and older with agerelated macular degeneration, diabetic retinopathy, glaucoma or cataracts from the 2008 and 2016 waves of the nationally-representative cross-sectional National Health Interview Survey (n=2875 and n=6233 respectively). Individuals who replied affirmatively to the question, “do you use any adaptive devices such as telescopic or other prescriptive lenses, magnifiers, large print or talking materials, CCTV, white cane or guide dogs?” were defined as adaptive device users. Descriptive statistics and logistic regression models of adaptive device use were estimated. The main regression models used 2008 data and included explanatory variables for vision-related limitations, other functional limitations, sociodemographic characteristics and the local availability of ophthalmologists and optometrists. 6.1% of the 2008 sample and 4.2% of the 2016 sample used adaptive devices, these percentages were significantly different. 31.4% of the 2008 sample and 24.0% of 2016 sample with multiple vision-related limitations used adaptive devices, these percentages were not significantly different. Based on previous research, adaptive device use among the subgroups with multiple vision-related limitations would be expected to improve functional ability. In the regression models, the likelihood of adaptive device use increased significantly with the number of vision-related limitations, family income and local ophthalmologist availability. The regression results provide evidence of socioeconomic and geographic disparities in adaptive device use in the U.S. Together the descriptive statistics and regression results suggest that public health strategies to increase access to adaptive devices are needed

Career and Mentorship Experiences of Women Educational Administrators in Rural Community Colleges

This study explored the topic of current women administrators and their mentorship experiences. The purpose is to examine if these individuals had a mentor at all and how that relationship evolved. There is a universal graying of administration in Higher Education Leadership and many institutions lack a long-term plan to mentor and replace the administrators after retirement. Many of the current leaders in rural education are approaching retirement opening many opportunities for new leaders to come in. Not only that, but there is a large disparity in the number of women educational leaders. One study by Wallace & Marchant (2009) looked at how females are being prepared for leadership in Australian universities and found an administrative gender gap where women hold only 24% of administrative positions and an age gap where more retirees will leave positions before new employees reach the qualification level. Women are not being prepared for leadership positions and often lack the qualifications to achieve such goals. These findings indicated an issue with learning opportunities, development opportunities, and career mobility. This study aimed to report how mentorship relationships came about and delves into the state of leadership training programs amongst Higher Education Leaders. Along that line it is important to discover if that working relationship helped prepare female administrators for their job and how that experience shaped their career