4,272 research outputs found

    Education and Occupation in The Misophonia Podcast

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    Misophonia is a disorder that involves a negative response to specific stimuli, commonly repetitive sounds, or movements. It is not in the DSM-5-TR, and in many cases, people with misophonia self-diagnose. They unite over their shared symptoms, such as the intense “anger, distress, disgust, and anxiety” they feel (Remmert et al., 2022, p. 2). The Misophonia Podcast is one platform where people who identify as having misophonia can share their experiences, providing over a hundred public testimonies from people with a range of backgrounds. Through these casual interviews, the guests with misophonia reveal details regarding their individual experiences with the disorder, including triggers/activators, coping mechanisms, and the emotions they experience. Little research exists on misophonia and its treatments (Ferrer-Torres et al., 2022, p. 18), leaving people with misophonia on their own to discover what strategies work best for them. As lifestyle choices may reflect a complex relationship with one’s mental disorder, this study analyzes how education level and occupation type may relate to the social support, coping mechanisms, and attitudes people have regarding their misophonia. The only significant correlation found was between job alone time and variety of coping mechanisms, but further research is needed to determine whether this correlation stems from the nature of the podcast and how the data was collected. The lack of significant findings suggests complexity within the misophonia community; people with misophonia can have similar experiences despite their varied lifestyles

    Frontier Lab for AI Readiness (FLAIR) Project

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    The Department of Teaching Innovation and Learning Technologies (TILT) at Fort Hays State University aims to establish the “Frontier Lab for AI Readiness” (FLAIR) to harness innovative artificial intelligence methods for the growth and development of Northwest Kansas. This initiative would position FHSU as the epicenter for AI training, education, and advancement on the Great Plains. FLAIR\u27s objectives are threefold: First, it will offer educational opportunities to FHSU students and the Northwest Kansas community, including certificates, badges, and apprenticeships, through genuine interdisciplinary collaborations. This lab will equip learners for an AI-focused workforce. Second, FLAIR would connect with the community to tackle rural-specific challenges by applying AI to support sectors like agriculture, education, healthcare, small businesses, data analysis, and community infrastructures. Last, it will ensure that AI\u27s transformative power benefits the regional economy by working closely with local enterprises to boost workforce development. By launching FLAIR, FHSU aims to become a leader in applied AI, foster interdisciplinary and community-wide technological collaborations, and chart a sustainable course for Northwest Kansas. As the integration of AI becomes more widespread, FHSU would be poised to lead its application in rural settings

    Higher-order compatible finite element schemes for the nonlinear rotating shallow water equations on the sphere

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    This is the final version. Available from Elsevier via the DOI in this record.We describe a compatible finite element discretisation for the shallow water equations on the rotating sphere, concentrating on integrating consistent upwind stabilisation into the framework. Although the prognostic variables are velocity and layer depth, the discretisation has a diagnostic potential vorticity that satisfies a stable upwinded advection equation through a Taylor–Galerkin scheme; this provides a mechanism for dissipating enstrophy at the gridscale whilst retaining optimal order consistency. We also use upwind discontinuous Galerkin schemes for the transport of layer depth. These transport schemes are incorporated into a semi-implicit formulation that is facilitated by a hybridisation method for solving the resulting mixed Helmholtz equation. We demonstrate that our discretisation achieves the expected second order convergence and provide results from some standard rotating sphere test problems.Natural Environment Research Council (NERC)Natural Environment Research Council (NERC)Engineering and Physical Sciences Research Council (EPSRC)Engineering and Physical Sciences Research Council (EPSRC

    A domain-specific language for the hybridization and static condensation of finite element methods

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    In this paper, we introduce a domain-specific language (DSL) for concisely expressing localized linear algebra on finite element tensors and its integration within a code-generation framework. This DSL is general enough to facilitate the automatic generation of element-based dense linear algebra kernels necessary for the implementation of static condensation methods and local solvers for a variety of problems. We demonstrate its use for the static condensation of continuous Galerkin problems, and systems arising from hybridizing finite element discretizations. We also describe how this DSL can be used to execute local post-processing procedures to construct superconvergent approximations to mixed problems. This work also features high-level implementations of static condensation and hybrid-mixed methods as preconditioners conforming to PETSc's interface for solving linear systems. These preconditioning interfaces provide reduced operators, which are obtained from locally assembled expressions, with the necessary context to specify full solver configurations on the resulting linear systems. We validate our implementations within the context of model second-order elliptic problems. Finally, we conclude with a performance comparison highlighting the use of a hybrid-mixed method as an efficient preconditioner in a semi-implicit method for the nonlinear rotating shallow water equations

    Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism

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    \ua9 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.Children diagnosed with acute myeloid leukaemia (paediatric AML [pAML]) have limited treatment options and relapse rates due to chemoresistance and refractory disease are over 30%. Current treatment is cytotoxic and in itself has long-lasting harsh side effects. New, less toxic treatments are needed. The bone marrow microenvironment provides chemoprotection to leukaemic cells through cell communication and interaction with mesenchymal stem cells (MSCs), but this is not well defined in pAML. Using primary patient material, we identify a cell contact-independent mechanism of MSC-mediated chemoprotection involving extrinsic soluble factors that is abrogated through inhibition of the JAK/STAT and ERK pathways

    Conservation must capitalise on climate’s moment

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    The health of the natural environment has never been a greater concern, but attention to biodiversity loss is being eclipsed by the climate crisis. We argue that conservationists must seize the agenda to put biodiversity at the heart of climate policy

    Identification of single-site gold catalysis in acetylene hydrochlorination

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    There remains considerable debate over the active form of gold under operating conditions of a recently validated gold catalyst for acetylene hydrochlorination. We have performed an in situ x-ray absorption fine structure study of gold/carbon (Au/C) catalysts under acetylene hydrochlorination reaction conditions and show that highly active catalysts comprise single-site cationic Au entities whose activity correlates with the ratio of Au(I):Au(III) present. We demonstrate that these Au/C catalysts are supported analogs of single-site homogeneous Au catalysts and propose a mechanism, supported by computational modeling, based on a redox couple of Au(I)-Au(III) species

    Observation of An Evolving Magnetic Flux Rope Prior To and During A Solar Eruption

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    Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of magnetic flux rope structure, a volumetric current channel, in producing explosive events. The flux rope is observed as a hot channel prior to and during a solar eruption from the Atmospheric Imaging Assembly (AIA) telescope on board the Solar Dynamic Observatory (SDO). It initially appears as a twisted and writhed sigmoidal structure with a temperature as high as 10 MK and then transforms toward a semi-circular shape during a slow rise phase, which is followed by fast acceleration and onset of a flare. The observations suggest that the instability of the magnetic flux rope trigger the eruption, thus making a major addition to the traditional magnetic-reconnection paradigm.Comment: 13 pages, 3 figure
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