Total Synthesis of (+)-Komarovispirone

(+)-Komaroviquinone photolytically rearranges to (+)-komarovispirone. A rationalization of this isomerization is presented

Total Synthesis of (−)-Barbatusol, (+)-Demethylsalvicanol, (−)-Brussonol, and (+)-Grandione^§

The icetexane-based diterpenes (−)-barbatusol, (+)-demethylsalvicanol, and (−)-brussonol were synthesized. Synthetic demethylsalvicanol was dimerized to produce (+)-grandione using aqueous Diels−Alder conditions

Total Synthesis of (−)-Barbatusol, (+)-Demethylsalvicanol, (−)-Brussonol, and (+)-Grandione^§

The icetexane-based diterpenes (−)-barbatusol, (+)-demethylsalvicanol, and (−)-brussonol were synthesized. Synthetic demethylsalvicanol was dimerized to produce (+)-grandione using aqueous Diels−Alder conditions

Total Synthesis of (+)-19-Deoxyicetexone, (−)-Icetexone, and (+)-5-<i>Epi</i>-icetexone

The first asymmetric total syntheses of 19-deoxyicetexone, icetexone, and 5-epi-icetexone was achieved from epimeric tricyclic dienes

Total Synthesis of (+)-19-Deoxyicetexone, (−)-Icetexone, and (+)-5-<i>Epi</i>-icetexone

The first asymmetric total syntheses of 19-deoxyicetexone, icetexone, and 5-epi-icetexone was achieved from epimeric tricyclic dienes

Total Synthesis of (+)-19-Deoxyicetexone, (−)-Icetexone, and (+)-5-<i>Epi</i>-icetexone

The first asymmetric total syntheses of 19-deoxyicetexone, icetexone, and 5-epi-icetexone was achieved from epimeric tricyclic dienes

Total Synthesis of (+)-19-Deoxyicetexone, (−)-Icetexone, and (+)-5-<i>Epi</i>-icetexone

The first asymmetric total syntheses of 19-deoxyicetexone, icetexone, and 5-epi-icetexone was achieved from epimeric tricyclic dienes

Total Synthesis of (−)-Salviasperanol^§

The achiral enynone shown cyclized to produce a tricyclic dienone that was converted in six steps to (−)-salviasperanol

Total Synthesis of (−)-Salviasperanol^§

The achiral enynone shown cyclized to produce a tricyclic dienone that was converted in six steps to (−)-salviasperanol

A Concise Synthesis of (+)-Salvadione B

The novel hexacyclic triterpene salvadione B was synthesized in seven steps from the chiral quinone shown. The insight gained from this synthesis permitted a two-step, one-pot sequence to introduce the three additional rings and seven chiral centers