Supplemental Figure S5 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S5. P5CS protein knockdown did not alter AKT or MAPK pathways or cause changes in apoptosis or autophagy.</p

Supplemental Figure Legends from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental figure legends for supplemental figures.</p

Supplemental Figure S2 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S2. Cell line melanoma tumor progression model shows levels of intracellular metabolites in each cell line.</p

Supplemental Figure S8 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S8. Proline supplementation did not restore protein synthesis in 1205 Lu cells by day 5.</p

Supplemental materials and methods from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental materials and methods for supplemental experiments.</p

SUPPLEMENTARY METHODS from The Role of Cholesterol in Cancer

DETAILS OF VARIOUS ANALYZES USED IN THE STUDY.</p

Supplemental Figure S9 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S9. P5CS protein knockdown did not inactivate the mTOR pathway.</p

Supplemental Figure S3 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S3. Ornithine, but not citrulline, supplementation partially reversed effects observed with P5CS protein knockdown.</p

Supplemental Figure S4 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S4. P5CS protein levels decreased in xenografted tumor lysates.</p

Supplemental Figure S6 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Supplemental Figure S6. P5CS protein knockdown did not consistently affect hydrogen peroxide or ROS levels.</p