Additional file 1 of External validation of inpatient neonatal mortality prediction models in high-mortality settings

Additional file 1: Table S1. Different types and meanings of datasets in predictive modelling. Table S2. Essential treatments prescribed at admission that were included as predictors. Table S3. Symptoms and signs of severe illness considered as candidate predictors. Table S4. Distribution of predictors for patients included in the SENSS model derivation, updating and external validation. Table S5. Distribution of predictors for patients included in the NETS model derivation, updating and external validation. Table S6. Hospital Specific Candidate Predictor Summaries. Table S7. Distribution of predictors and missingness in SENSS external validation dataset by in-hospital mortality. Table S8. Distribution of predictors in NETS external validation dataset by in-hospital mortality

Additional file 2 of External validation of inpatient neonatal mortality prediction models in high-mortality settings

Additional file 2. Model recalibration approaches evaluated

Additional file 1 of Playing sport injured is associated with osteoarthritis, joint pain and worse health-related quality of life: a cross-sectional study

Additional file 1: Appendix 1. Questions and potential response

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production-9

●), or 4-HPR (■) for 48 h were examined for IFN-γ or IL-12 protein levels by ELISA analysis. The values shown represent the average fold change obtained from 4 donors.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

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anti-CD3,-activated PBMC treated with EtOH, ATRA (10M), an RAR- α agonist, AM580 (10M), or an RAR- α antagonist, RO 41–5254 (10M). Values obtained for each cytokine message was normalized to that obtained for 18S rRNA in the same sample as described in "Materials and Methods". The normalized values were then expressed as a function of the ETOH control sample. The data are representative of all of the donors tested.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production-7

Nts of 48 h, anti-CD3,-activated PBMC treated in the absence or presence of EtOH, ATRA (10M), or the RAR-α agonist, AM580 (10M) and in the presence or absence of EtOH (□) or the RXR agonist (10M, ■). The above data are representative of the results from two different donors examined.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production-8

●), or 4-HPR (■) for 48 h were examined for IL-4 or IL-5. The values shown represent the average fold change obtained from 4 donors.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

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Th ETOH or ATRA (○), 9--RA (□), 13--RA (●), or 4-HPR (■). The values for the level of expression (mean channel number) of CD38 and CD69 on T cells were obtained by flow cytometry of cells from the same culture. Simple regression was performed on these values as described in . Data shown is average fold change calculated from three experiments.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production-3

C treated with EtOH, ATRA (10M), the RAR-α agonist, AM580 (10M), or an RAR- α antagonist, RO 41-5254 (10M). The values shown represent the average obtained from 4 donors ± SEM. Means that express different superscripts are significantly different by at least p < 0.02.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production-4

CD3,-activated PBMC treated with control EtOH, ATRA (10M), AM580 (10M), or an RAR- α antagonist, RO 41–5254 (10M). The values shown represent the average obtained from 4 donors ± SEM. Means that express different superscripts are significantly different by at least p < 0.03.<p><b>Copyright information:</b></p><p>Taken from "The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production"</p><p>http://www.biomedcentral.com/1471-2172/9/16</p><p>BMC Immunology 2008;9():16-16.</p><p>Published online 16 Apr 2008</p><p>PMCID:PMC2394516.</p><p></p