The fourth-revolution in the water sector encounters the digital revolution

The so-called fourth revolution in the water sector will encounter the Big data and Artificial Intelligence (AI) revolution. The current data surplus stemming from all types of devices together with the relentless increase in computer capacity is revolutionizing almost all existing sectors, and the water sector will not be an exception. Combining the power of Big data analytics (including AI) with existing and future urban water infrastructure represents a significant untapped opportunity for the operation, maintenance, and rehabilitation of urban water infrastructure to achieve economic and environmental sustainability. However, such progress may catalyze socio-economic changes and cross sector boundaries (e.g., water service, health, business) as the appearance of new needs and business models will influence the job market. Such progress will impact the academic sector as new forms of research based on large amounts of data will be possible, and new research needs will be requested by the technology industrial sector. Research and development enabling new technological approaches and more effective management strategies are needed to ensure that the emerging framework for the water sector will meet future societal needs. The feature further elucidates the complexities and possibilities associated with such collaborations.Manel Garrido-Baserba and Diego Rosso acknowledge the United States Department of Energy (CERC-WET US Project 525 2.5). Lluís Corominas acknowledges the Ministry of Economy and competitiveness for the Ramon and Cajal grant (RYC2013-465 14595) and the following I3. We thank Generalitat de Catalunya through Consolidated Research Group 2017 SGR 1318. ICRA researchers acknowledge funding from the CERCA program.Peer ReviewedPostprint (author's final draft

Cost-effectiveness of rifampin for 4 months and isoniazid for 6 months in the treatment of tuberculosis infection

SummaryObjectivesTo assess the cost-effectiveness ratio of rifampin for 4 months and isoniazid for 6 months in contacts with latent tuberculosis infection.MethodsThe cost was the sum of the cost of treatment with isoniazid for 6 months or with rifampin for 4 months of all contacts plus the cost of treatment of cases of tuberculosis not avoided. The effectiveness was the number of cases of tuberculosis avoided with isoniazid for 6 months or with rifampin for 4 months. When the cost with one schedule was found to be cheaper than the other and a greater number of tuberculosis cases were avoided, this schedule was considered dominant. The efficacy adopted was 90% for rifampin for 4 months and 69% for isoniazid for 6 months. A sensitivity analysis was made for efficacies of rifampin for 4 months of 80%, 69%, 60% and 50%.ResultsOf the 1002 patients studied, 863 were treated with isoniazid for 6 months and 139 with rifampin for 4 months The cost-effectiveness ratio with isoniazid for 6 month was € 19759.48/avoided case of tuberculosis and € 8736.86/avoided case of tuberculosis with rifampin for 4 months. Rifampin for 4 months was dominant. In the sensitivity analysis, rifampin for 4 months was dominant for efficacies from 60%.ConclusionsRifampin for 4 months was more cost-effective than isoniazid for 6 months

Aproximación a la checklist de los gipsófitos ibéricos

Approximation to the Iberian gypsophytes checklist. The close relationship between some kinds of soils and the flora growing on them has been long known. Gypsum soils stand as a prominent example of this relationship, since some plants exclusively grow on gypsum outcrops. Nowadays this close relationship is known as gypsophily and the plant species exhibiting it are called gypsophytes. As Cavanilles already found out in the 18th century, the Iberian flora is rich in gypsophytes. From then on many botanists have considerably enlarged the list of gypsophytes. However we still lack a more or less conclusive catalogue of the Iberian gypsophytes. Only some publications dealing with the gypsum flora or vegetation may serve as references for the drafting of a preliminary catalogue. This idea has recently inspired a preliminary list of gypsophytes which has been later enlarged with the addition of new species recorded now and then in a number of specific Floras and other works of a general scope. On the basis of this list, 12 botanists adept at gypsum flora have been asked to rank the liking of these species for gypsum soils. The gypsophilous character of 140 species have been thus ranked on a scale ranging from 1 to 5 (with 5 representing an absolute liking for gypsum soils). According to the median values, some 50 species can be considered as either absolute or preferent gypsophytes

Observation of the decay Λb0 → χc1pπ−

The Cabibbo-suppressed decay Λ 0 b → χc1pπ − is observed for the first time using data from proton-proton collisions corresponding to an integrated luminosity of 6 fb−1 , collected with the LHCb detector at a centre-of-mass energy of 13 TeV. Evidence for the Λ 0 b → χc2pπ − decay is also found. Using the Λ 0 b → χc1pK− decay as normalisation channel, the ratios of branching fractions are measured to be B Λ 0 b → χc1pπ − B Λ0 b → χc1pK− = (6.59 ± 1.01 ± 0.22) × 10−2 , B Λ 0 b → χc2pπ − B Λ0 b → χc1pπ− = 0.95 ± 0.30 ± 0.04 ± 0.04 , B Λ 0 b → χc2pK− B Λ0 b → χc1pK− = 1.06 ± 0.05 ± 0.04 ± 0.04 , where the first uncertainty is statistical, the second is systematic and the third is due to the uncertainties in the branching fractions of χc1,2 → J/ψγ decays. Keywords: B physics, Branching fraction, Hadron-Hadron scattering (experiments), QCD, Qua

Blood Phytosterol Concentration and Genetic Variant Associations in a Sample Population

The main objective of this study was to determine plasma levels of PS and to study SNVs rs41360247, rs4245791, rs4148217, and rs11887534 of ABCG8 and the r657152 SNV at the ABO blood group locus in a sample of a population treated at our hospital, and to determine whether these SNVs are related to plasma PS concentrations. The secondary objective was to establish the variables associated with plasma PS concentrations in adults. Participants completed a dietary habit questionnaire and a blood sample was collected to obtain the following variables: campesterol, sitosterol, sitostanol, lanosterol, stigmasterol, biochemical parameters, and the SNVs. In addition, biometric and demographic variables were also recorded. In the generalized linear model, cholesterol and age were positively associated with total PS levels, while BMI was negatively related. For rs4245791, homozygous T allele individuals showed a significantly lower campesterol concentration compared with C homozygotes, and the GG alleles of rs657152 had the lowest levels of campesterol compared with the other alleles of the SNV. Conclusions: The screening of certain SNVs could help prevent the increase in plasma PS and maybe PNALD in some patients. However, further studies on the determinants of plasma phytosterol concentrations are needed

Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome

Non-obstructive azoospermia, a severe form of male infertility caused by spermatogenic failure (SPGF), has a largely unknown genetic basis across ancestries. To our knowledge, this is the first trans-ethnic meta-analysis of genome-wide association studies on SPGF, involving 2255 men with idiopathic SPGF and 3608 controls from European and Asian populations. Using logistic regression and inverse variance methods, we identify two significant genetic associations with Sertoli cell-only (SCO) syndrome, the most extreme SPGF phenotype. The G allele of rs34915133, in the major histocompatibility complex class II region, significantly increases SCO risk (P = 5.25E-10, OR = 1.57), supporting a potential immune-related cause. Additionally, the rs10842262 variant in the SOX5 gene region is also a genetic marker of SCO (P = 5.29E-09, OR = 0.72), highlighting the key role of this gene in the male reproductive function. Our findings reveal shared genetic factors in male infertility across ancestries and provide insights into the molecular mechanisms underlying SCO

Famílies botàniques de plantes medicinals

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome.

We aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood–testis barrier, in the genetic risk of developing male infertility due to a severe spermatogenic failure (SPGF). Genotyping was performed using TaqMan genotyping assays for three PIN1 taggers (rs2287839, rs2233678 and rs62105751). The study cohort included 715 males diagnosed with SPGF and classified as suffering from non-obstructive azoospermia (NOA, n = 505) or severe oligospermia (SO, n = 210), and 1058 controls from the Iberian Peninsula. The allelic frequency differences between cases and controls were analyzed by the means of logistic regression models. A subtype specific genetic association with the subset of NOA patients classified as suffering from the Sertoli cell-only (SCO) syndrome was observed with the minor alleles showing strong risk effects for this subset (ORrs2287839 = 1.85 (1.17–2.93), ORrs2233678 = 1.62 (1.11–2.36), ORrs62105751 = 1.43 (1.06–1.93)). The causal variants were predicted to affect the binding of key transcription factors and to produce an altered PIN1 gene expression and isoform balance. In conclusion, common non-coding single-nucleotide polymorphisms located in PIN1 increase the genetic risk to develop SCO.This work was supported by the Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) (ref. PY20_00212, P20_00583), and the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (ref. SAF2016–78722-R, PID2020–120157RB-I00) and the Proyectos I + D + i del Programa Operativo FEDER 2020 (ref. B-CTS-584-UGR20, B-CTS-260-UGR20). FDC was supported by the “Ramón y Cajal” program (ref. RYC-2014–16458), and LBC was supported by the Spanish Ministry of Economy and Competitiveness through the “Juan de la Cierva Incorporación” program (Grant ref. IJC2018–038026-I, funded by MCIN/AEI/10.13039/501100011033), all of them including FEDER funds. AGJ was funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”(grant ref. FPU20/02926). SGM was funded by a previously mentioned project (ref. PY20_00212). IPATIMUP integrates the i3S Research Unit, which is partially supported by the Portuguese Foundation for Science and Technology (FCT), financed by the European Social Funds (COMPETE-FEDER) and National Funds (projects PEstC/SAU/LA0003/2013 and POCI-01–0145-FEDER-007274). AML is funded by the Portuguese Government through FCT (IF/01262/2014). PIM is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Technology and High Education and from the European Social Fund, available through the Programa Operacional do Capital Humano. ToxOmics—Centre for Toxicogenomics and Human Health, Genetics, Oncology and Human Toxicology, Nova Medical School, Lisbon, is also partially supported by FCT (Projects: UID/BIM/00009/2013 and UIDB/UIDP/00009/2020). SLarriba received support from Instituto de Salud Carlos III (grant DTS18/00101], co-funded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe), and from “Generalitat de Catalunya” (grant 2017SGR191). SLarriba is sponsored by the “Researchers Consolidation Program” from the SNS-Dpt. Salut Generalitat de Catalunya (Exp. CES09/020). This article is related to the Ph.D. Doctoral Thesis of Miriam Cerván-Martín (grant ref. BES-2017–081222 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”)