102 research outputs found
Serviceability performance of buildings founded on rubber–soil mixtures for geotechnical seismic isolation
Base isolation is a low-damage seismic design strategy that can be used for constructing resilient structures. Geotechnical seismic isolation (GSI) is a new category of emerging base isolation techniques that has attracted global interest in the past decade. Research on GSI based on rubber-soil mixtures (RSM) has focused on structural performance under earthquake actions, whilst there are concerns over the serviceability limit states (SLS) requirements in relation to (i) human comfort under strong winds and (ii) ground settlement under gravity, which may induce cracking and durability issues in structures. This article presents the first study on the serviceability performance of buildings constructed with the GSI-RSM system. The finite element model of a coupled soil-foundation-structure system has been validated by data recorded from geotechnical centrifuge testing. The numerical estimates of ground settlement have also been compared with analytical predictions. It is concluded that the GSI-RSM system can satisfactorily fulfill the SLS requirements
Serviceability performance of buildings founded on rubber–soil mixtures for geotechnical seismic isolation
Base isolation is a low-damage seismic design strategy that can be used for constructing resilient structures. Geotechnical seismic isolation (GSI) is a new category of emerging base isolation techniques that has attracted global interest in the past decade. Research on GSI based on rubber-soil mixtures (RSM) has focused on structural performance under earthquake actions, whilst there are concerns over the serviceability limit states (SLS) requirements in relation to (i) human comfort under strong winds and (ii) ground settlement under gravity, which may induce cracking and durability issues in structures. This article presents the first study on the serviceability performance of buildings constructed with the GSI-RSM system. The finite element model of a coupled soil-foundation-structure system has been validated by data recorded from geotechnical centrifuge testing. The numerical estimates of ground settlement have also been compared with analytical predictions. It is concluded that the GSI-RSM system can satisfactorily fulfill the SLS requirements
Geotechnical seismic isolation based on high-damping polyurethane:centrifuge modelling
Geotechnical seismic isolation (GSI) is a new category of low-damage resilient design methods that are in direct contact with geomaterials and of which the isolation mechanism primarily involves geotechnics. Various materials have been explored for placing around the foundation system in layer form to facilitate the beneficial effects of dynamic soil-foundation-structure interaction, as one of the GSI mechanisms. To reduce the thickness of the GSI foundation layer and to ensure uniformity of its material properties, the use of a thin and homogeneous layer of high-damping polyurethane (HDPU) was investigated in this study via centrifuge modelling. HDPU sheets were installed in three different configurations at the interface between the structural foundation and surrounding soils for realising GSI. It was found that using HDPU for GSI can provide excellent seismic isolation effects in all three configurations. The average rates of structural demand reduction amongst the eight earthquake events ranged from 35 to 80%. A clear correlation between the period-lengthening ratio and the demand reduction percentage can be observed amongst the three GSI configurations. One of the configurations with HDPU around the periphery of the foundation only is particularly suitable for retrofitting existing structures and does not require making changes to the structural systems or architectural features.</p
Geotechnical seismic isolation based on high-damping polyurethane:centrifuge modelling
Geotechnical seismic isolation (GSI) is a new category of low-damage resilient design methods that are in direct contact with geomaterials and of which the isolation mechanism primarily involves geotechnics. Various materials have been explored for placing around the foundation system in layer form to facilitate the beneficial effects of dynamic soil-foundation-structure interaction, as one of the GSI mechanisms. To reduce the thickness of the GSI foundation layer and to ensure uniformity of its material properties, the use of a thin and homogeneous layer of high-damping polyurethane (HDPU) was investigated in this study via centrifuge modelling. HDPU sheets were installed in three different configurations at the interface between the structural foundation and surrounding soils for realising GSI. It was found that using HDPU for GSI can provide excellent seismic isolation effects in all three configurations. The average rates of structural demand reduction amongst the eight earthquake events ranged from 35 to 80%. A clear correlation between the period-lengthening ratio and the demand reduction percentage can be observed amongst the three GSI configurations. One of the configurations with HDPU around the periphery of the foundation only is particularly suitable for retrofitting existing structures and does not require making changes to the structural systems or architectural features.</p
Performance of geotechnical seismic isolation system using rubber-soil mixtures in centrifuge testing
Geotechnical seismic isolation (GSI) system involves the dynamic interaction between structure and low-modulus foundation material, such as rubber-soil mixtures (RSM). Whilst numerical studies have been carried out to demonstrate the potential benefits of GSI-RSM system, experimental research is indispensable for confirming its isolation mechanism and effectiveness in reducing structural demand. In this regard, centrifuge modelling with an earthquake shaker under an acceleration field of 50 g adopted in this study can mimic the actual nonlinear dynamic response characteristics of RSM and subsoil in a coupled soil-foundation-structure system. This is the first time the performance of GSI-RSM system was examined in a geotechnical centrifuge. It was found that an average of 40-50% reduction of structural demand can be achieved. The increase in both the horizontal and rotation responses of the foundation was also evidenced. The unique augmented rocking mechanism with reversible foundation rotation was highlighted.</p
Fundamental Role of Neurochemicals Aberration in the Pathogenesis of Autism Spectrum Disorders
AIM: The aim of this research was to establish the perturbation of reliable biomarkers implicated in the pathophysiology of autism to help in the early diagnosis and to be as targets in the treatment of autism spectrum disorders (ASDs) in children and to spotlight into the complex crosstalk between these biomarkers.
PATIENS AND METHODS: This study included 90 autistic children aged from 2 to 7 years old, who were classified into two groups, the atypical autism of 30 children and the childhood autism. The childhood autism group was further divided into mild-moderate autism group and severe autism group each of 30 children. The control group included 30 matched healthy children. All the participants were subjected to full psychiatric examinations, psychological investigations, and biochemical measurements, including gamma-aminobutaric acid (GABA), serotonin, dopamine (DA) in plasma, and brain-derived neurotrophic factor (BDNF) in serum.
RESULTS: The autistic groups showed a highly significant increase in GABA, serotonin, DA, and BDNF levels compared to the control. Of note, the levels of GABA, DA, and BDNF were significantly increased with the increased disease severity. Furthermore, a significant positive correlation between BDNF levels and both GABA and DA levels in the childhood autism group has been recorded.
CONCLUSION: The present clinical setting provides new insight into the fundamental role of BDNF in the brain of autistic children as any alterations of its level due to GABA increment cause change in serotonin and DA levels which have empirical evidence in the pathophysiology of ASD. The results received in this research, create a fertile base for the setup of particular targets in the intervention of this ailment
Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019
Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe