Fundamental stellar and accretion disc parameters of the eclipsing binary DQ Velorum

To add to the growing collection of well-studied double periodic variables (DPVs) we have carried out the first spectroscopic and photometric analysis of the eclipsing binary DQ Velorum to obtain its main physical stellar and orbital parameters. Combining spectroscopic and photometric observations that cover several orbital cycles allows us to estimate the stellar properties of the binary components and the orbital parameters. We also searched for circumstellar material around the more massive star. We separated DQ Velorum composite spectra and measured radial velocities with an iterative method for double spectroscopic binaries. We obtained the radial velocity curves and calculated the spectroscopic mass ratio. We compared our single-lined spectra with a grid of synthetic spectra and estimated the temperature of the stars. We modeled the V-band light curve with a fitting method based on the simplex algorithm, which includes an accretion disc. To constrain the main stellar parameters we fixed the mass ratio and donor temperature to the values obtained by our spectroscopic analysis. We obtain donor and gainer masses, the radii, and temperatures for the stellar components. We find that DQ Vel is a semi-detached system consisting of a B3V gainer and an A1III donor star plus an extended accretion disc around the gainer. The disc is filling 89% of the gainer Roche lobe and it has a concave shape that is thicker at its edge than at its centre. We find a significant sub-orbital frequency of 0.19 d^{-1} in the residuals of the V-band light curve, which we interpret as a pulsation of an slowly pulsating B-type (SPB) of a gainer star. We also estimate the distance to the binary (3.1 kpc) using the absolute radii, apparent magnitudes, and effective temperatures of the components found in our study.Comment: 12 pages, 13 Postscript figure

Adaptive Horizon Model Predictive Control and Al'brekht's Method

A standard way of finding a feedback law that stabilizes a control system to an operating point is to recast the problem as an infinite horizon optimal control problem. If the optimal cost and the optmal feedback can be found on a large domain around the operating point then a Lyapunov argument can be used to verify the asymptotic stability of the closed loop dynamics. The problem with this approach is that is usually very difficult to find the optimal cost and the optmal feedback on a large domain for nonlinear problems with or without constraints. Hence the increasing interest in Model Predictive Control (MPC). In standard MPC a finite horizon optimal control problem is solved in real time but just at the current state, the first control action is implimented, the system evolves one time step and the process is repeated. A terminal cost and terminal feedback found by Al'brekht's methoddefined in a neighborhood of the operating point is used to shorten the horizon and thereby make the nonlinear programs easier to solve because they have less decision variables. Adaptive Horizon Model Predictive Control (AHMPC) is a scheme for varying the horizon length of Model Predictive Control (MPC) as needed. Its goal is to achieve stabilization with horizons as small as possible so that MPC methods can be used on faster and/or more complicated dynamic processes.Comment: arXiv admin note: text overlap with arXiv:1602.0861

Binaries with total eclipses in the LMC: potential targets for spectroscopy

35 Eclipsing binaries presenting unambiguous total eclipses were selected from a subsample of the list of Wyrzykowski et al. (2003). The photometric elements are given for the I curve in DiA photometry, as well as approximate Teff and masses of the components. The interest of these systems is stressed in view of future spectroscopic observations.Comment: 4 pages, 1 figure; poster presented at the conference "Close binaries in the 21st Century: new opportunities and challenges", Syros, 27-30 June 200

UVSat: a concept of an ultraviolet/optical photometric satellite

Time-series photometry from space in the ultraviolet can be presently done with only a few platforms, none of which is able to provide wide-field long-term high-cadence photometry. We present a concept of UVSat, a twin space telescope which will be capable to perform this kind of photometry, filling an observational niche. The satellite will host two telescopes, one for observations in the ultraviolet, the other for observations in the optical band. We also briefly show what science can be done with UVSat.Comment: 6 pages, 2 figures, accepted for publication in the Proceedings of the PAS (Proc. of the 2nd BRITE Science conference, Innsbruck

Detached binaries in the Large Magellanic Cloud. A selection of binaries suitable for distance determination

As a result of a careful selection of eclipsing binaries in the Large Magellanic Cloud using the OGLE-II photometric database, we present a list of 98 systems that are suitable targets for spectroscopic observations that would lead to the accurate determination of the distance to the LMC. For these systems we derive preliminary parameters combining the OGLE-II data with the photometry of MACHO and EROS surveys. In the selected sample, 58 stars have eccentric orbits. Among these stars we found fourteen systems showing apsidal motion. The data do not cover the whole apsidal motion cycle, but follow-up observations will allow detailed studies of these interesting objects.Comment: 15 pages, 6 figures, accepted for publication in A&

Discovery of the first dual GSK3 beta inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease

The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. These pathological hallmarks are closely related to the over-activity of the enzyme GSK3β and the downregulation of the defense pathway Nrf2-EpRE observed in AD patients. Herein, we report the synthesis and pharmacological evaluation of a new family of multitarget 2,4-dihydropyrano[2,3-c]pyrazoles as dual GSK3β inhibitors and Nrf2 inducers. These compounds are able to inhibit GSK3β and induce the Nrf2 phase II antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure-activity relationships. The association of both activities has resulted in a remarkable anti-inflammatory ability with an interesting neuroprotective profile on in vitro models of neuronal death induced by oxidative stress and energy depletion and AD. Furthermore, none of the compounds exhibited in vitro neurotoxicity or hepatotoxicity and hence they had improved safety profiles compared to the known electrophilic Nrf2 inducers. In conclusion, the combination of both activities in this family of multitarget compounds confers them a notable interest for the development of lead compounds for the treatment of AD

What drives political participation? Motivations and Mobilization in a Digital Age

The article provides insights into the driving forces that underpin new forms of political participation. Digital technologies offer opportunities for engaging in a wide range of civically-oriented activities, whether liking or sharing political content, joining online political communities or joining discussions, each can contribute to deeper democratic engagement and, for the individual, act as a pathway towards further civic participation. Conventional acts of political participation, demonstrating, petitioning and voting, are argued to be driven primarily by intrinsic motivations relating to self-efficacy and empowerment as the individual feels they can have influence over decision makers. Little research explores whether similar motivations drive participation in less conventional acts, as well as whether mobilisation attempts via social media by peers or political organisations mediate those motivations. Drawing on data from a survey among a representative sample of the UK electorate, we find the offline and online spheres of agency as still fairly distinct. Intrinsic and extrinsic motivations both matter but extrinsic motivations, following norms of behaviour within networks and supporting the activities of peers, have the strongest explanatory power independent of the sphere of activity. The mediating effect of mobilisation tactics has a minimal effect on extrinsic motivations, online or offline, but online intrinsic motivations lose their explanatory power. This finding suggests online political acts are carried out due to mobilisation, although as intrinsic factors offer little explanatory power these acts may lack meaning to the individual. We also found that campaign organisations are the most powerful mobilisers perhaps suggesting social media users are most likely to perform simple acts in support of non-contentious causes