49 research outputs found

    Successful cricothyrotomy for emergency airway management : a case report

    Get PDF
    A 60 year-old male was brought to our emergency department by ambulance due to sudden onset of dyspnea. On examination, he was in coma since his level of consciousness decreased during transport, blood pressure was 199/111mmHg, heart rate was100 beats per minute, respirations were 10 per minute, blood oxygen saturation level(SpO2)was100% via assisted ventilation with Bag-Valve-Mask, and stridor was heard on auscultation. Those findings indicated airway emergency and endotracheal intubation was required. However, attempts at intubation were unsuccessful due to restriction of mouth opening. Muscle relaxant was then given to perform rapid sequence intubation, which caused vomiting. Failure to ventilation and intubation resulted in cardiopulmonary arrest. Chest compression was started immediately and decision for cricothyrotomy was made. 10 minute after cricothyrotomy, he revived. Subsequently, systemic management including therapeutic normothermia was performed at intensive care unit, then he regained consciousness. He was discharged 1 month after admission

    Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

    Get PDF
    Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

    The role of potassium on the remediation for the radiocesium contaminated soil

    Get PDF
    The Tokyo Electric Company's Fukushima Dai-ichi Nuclear Power Plant accident contaminated a large area of agricultural land with radioactive cesium. If the contamination levels were high, topsoil removal or inversion tillage were the major countermeasures used to decrease the radioactivity of the soil. However, a substantial level of radioactive cesium remained in the soil, even after decontamination and some fields weren't decontaminated. To mitigate radioactive cesium transfer from soil to plant, we tested increasing potassium levels in the soil. In this paper, we demonstrate how we developed these countermeasures in Fukushima

    Possible solubilization of various mineral elements in the rhizosphere of Lupinus albus L

    Get PDF
    Lupinus albus L. (lupin) has a high tolerance for phosphorus deficient conditions as its roots can solubilize the unavailable phosphorus in the rhizosphere soil. The roots may also be able to solubilize other elements, but this requires further investigation. In this study, therefore, we conducted two experiments to comprehensively investigate the effects of lupin roots on the mineral dynamics of the rhizosphere soil. First, a mixed cropping experiment was conducted, in which lupin shared a rhizosphere with soybean (Glycine max (L.) Merr.) in a long-term experimental field with four fertilizer treatments: complete fertilization (+NPK), without nitrogen (-N), without phosphorus (-P), and without potassium (-K). The results of shoot dry weight of plants cultivated alone indicated that lupin is highly tolerant to all N, P, and K deficiencies, while soybean can adapt to N deficiency with the help of rhizobia but is less tolerant to P and K deficiencies than lupin. When mixed-cropped with lupin, the concentrations of many elements in the soybean leaf increased, particularly with the -N and -P treatments. Furthermore, soybean growth was significantly improved when cropped with lupin in the -N and -P treatments. Second, a comparison of the elemental profiles of hydroponically and field-soil-grown plants was conducted. Under hydroponic conditions, the rhizosphere effect is negligible when the culture medium is well circulated. The lupin/soybean ratios for leaf mineral concentrations were considerably larger in the field cultivated plants when compared with the hydroponic cultivations for elements such as sodium, potassium, cesium, phosphorus, iron, copper, and molybdenum, as there were lower concentrations of these elements in the soybean leaves in the field. These results indicate that lupin roots can solubilize a variety of insoluble elements in the soil, which may be the reason why lupin can adapt to various nutrient deficient soils. In the lupin rhizosphere, the solubilization of cesium, which is generally strongly fixed by soil minerals and not easily leached, was particularly pronounced. This implies that the surface structure of clay minerals might be altered in the lupin rhizosphere, resulting in the fixed forms of various elements becoming available

    Synthesis of γ-Lactams from Acrylamides by Single-Carbon Atom Doping Annulation

    Full text link
    A protocol for single-carbon atom doping annulation is reported, which enables the conversion of acrylamides into homologated γ-lactams through the cleavage of two σ-bonds and the formation of four new σ-bonds at the single carbon center. The key strategy is the use of N-heterocyclic carbenes as an atomic carbon equivalent by acting as carbon atom donors through the loss of a 1,2-diimine moiety. Experimental and computational studies reveal that the reaction proceeds through a spirocyclic intermediate, followed by the disassembly of the N-heterocyclic carbene skeleton via proton transfer.Fujimoto H., Nakayasu B., Tobisu M.. Synthesis of γ-Lactams from Acrylamides by Single-Carbon Atom Doping Annulation. Journal of the American Chemical Society 145, 19518 (2023); https://doi.org/10.1021/jacs.3c07052

    Non-Stabilized Vinyl Anion Equivalents from Styrenes by N-Heterocyclic Carbene Catalysis and Its Use in Catalytic Nucleophilic Aromatic Substitution

    Full text link
    A protocol for the catalytic nucleophilic activation of unactivated styrenes is reported, which enables the generation of a non-stabilized alkenyl anion equivalent as a transient intermediate. In the reaction, N-heterocyclic carbenes add across styrenes to generate ylide intermediates, which can then be used in intramolecular nucleophilic aromatic substitution reactions of aryl fluorides, chlorides, and methyl ethers. The method allows for straightforward access to complex polyaromatic compounds.Ito S., Fujimoto H., Tobisu M.. Non-Stabilized Vinyl Anion Equivalents from Styrenes by N-Heterocyclic Carbene Catalysis and Its Use in Catalytic Nucleophilic Aromatic Substitution. Journal of the American Chemical Society, 144, 15, 6714-6718, April 11, 2022. © 2022 American Chemical Society. https://doi.org/10.1021/jacs.2c02579

    Synthesis of γ-Lactams from Acrylamides by Single-Carbon Atom Doping Annulation

    No full text
    Fujimoto H., Nakayasu B., Tobisu M.. Synthesis of γ-Lactams from Acrylamides by Single-Carbon Atom Doping Annulation. Journal of the American Chemical Society 145, 19518 (2023); https://doi.org/10.1021/jacs.3c07052.A protocol for single-carbon atom doping annulation is reported, which enables the conversion of acrylamides into homologated γ-lactams through the cleavage of two σ-bonds and the formation of four new σ-bonds at the single carbon center. The key strategy is the use of N-heterocyclic carbenes as an atomic carbon equivalent by acting as carbon atom donors through the loss of a 1,2-diimine moiety. Experimental and computational studies reveal that the reaction proceeds through a spirocyclic intermediate, followed by the disassembly of the N-heterocyclic carbene skeleton via proton transfer

    Phosphine-Catalyzed Intermolecular Acylfluorination of Alkynes via a P(V) Intermediate

    No full text
    We report on the phosphine-catalyzed intermolecular carbofluorination of alkynes using acyl fluorides as fluorinating reagents. This reaction promises to be a useful method for the synthesis of highly substituted monofluoroalkene derivatives, since acyl fluorides can be easily prepared from the corresponding carboxylic acid derivatives and the reaction proceeds under ambient conditions without the need for a transition-metal catalyst. Experimental and computational studies indicate that a five-coordinated fluorophosphorane is involved as the key intermediate in the fluorination step
    corecore