Supplementary_figure_1 – Supplemental material for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells

<p>Supplemental material, Supplementary_figure_1 for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells by Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li and Marianna Kulka in International Journal of Immunopathology and Pharmacology</p

Supplementary_figure_3 – Supplemental material for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells

<p>Supplemental material, Supplementary_figure_3 for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells by Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li and Marianna Kulka in International Journal of Immunopathology and Pharmacology</p

Supplementary_figure_2 – Supplemental material for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells

<p>Supplemental material, Supplementary_figure_2 for Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells by Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li and Marianna Kulka in International Journal of Immunopathology and Pharmacology</p

Ruthenium(II)-Catalyzed Regioselective Ortho C–H Allenylation of Electron-Rich Aniline and Phenol Derivatives

Ortho C–H allenylation of electron-rich benzene derivatives with propargylic alcohol derivatives has been a challenge, due to their great innate tendency toward a para C–H allenylation via an SN2′-type substitution process. Here, we described a Ru­(II)-catalyzed regioselective ortho C–H allenylation of electron-rich aniline and phenol derivatives, which allows the previously challenging synthesis of a broad range of ortho allenylated aniline and phenol derivatives. More significantly, highly optically active fully substituted allenes can also be prepared with high enantiomeric excess via a highly efficient chirality transfer. No para C–H allenylation product was observed in the current catalytic system, thus showing a complete reversibility of the regioselectivity

Nine sesquiterpenes from <i>Solanum torvum</i>

<p>Three new sesquiterpenes, namely 3<i>β</i>,11-dihydroxy-4,14-oxideenantioeudesmane (<b>1</b>), 1<i>β</i>,10<i>β</i>,12,14-tetrahydroxy-<i>allo</i>-aromadendrane (<b>2</b>) and 1<i>β</i>,10<i>β</i>,13,14-tetrahydroxy-<i>allo</i>-aromadendrane (<b>3</b>), along with six known sesquiterpenes (<b>4</b>–<b>9</b>), were isolated from the roots of <i>Solanum torvum</i>. Compound <b>4</b> and <b>5</b> are epimers, their main difference lies in the C-11 configulation. Normally, epimers do not make a huge difference in C NMR spectra, but in this kind of structure of A, B, C rings, and C ring is sterically strained structure, stericall effects influence strongly the ¹³C NMR chemical shifts, when C-11 configulation changed, it makes a huge difference in the three ring of structure, such as C-6, C-7, C-11. New compound <b>2</b> and <b>3</b> are epimers and similar to compound <b>4</b> and <b>5</b>, their just increase a hydroxy in C-1 and have a same regular pattern in C NMR spectra, otherwise, compound <b>5</b> was firstly confirmed by single-crystal X-ray diffraction.</p

Inhibitors of BRD4 protein from the roots of <i>Astilbe grandis</i> stapf ex E.H. Wilson

A new monoterpene (1) along with eight known compounds were isolated from the roots of Astilbe grandis Stapf ex E.H. Wilson. Their structures were determined by extensive spectroscopic analysis and ECD experiments as (S)-3-(2-hydroxyethyl)-5-(2-methylprop-1-en-1-yl)furan-2(5H)-one (1), caffeic acid (2), mandelic acid (3), sonchifolinin B (4), α-viniferin (5), euscaphic acid (6), cianidanol (7), β-sitosterol (8), and stigmasterol (9), respectively. Compounds 5 and 6 exhibited inhibitory effects against BRD4 protein with IC50 values of 13.20 and 17.39 µM, respectively. In vitro, compounds 5 and 6 showed moderate cytotoxicity to A549 cells, HCC827 cells and Hela cells with IC50 values ranging from 31.98 to 154.90 µM.</p

Efficient Determination of the Enantiomeric Purity and Absolute Configuration of Flavanones by Using (<i>S</i>)‑3,3′-Dibromo-1,1′-bi-2-naphthol as a Chiral Solvating Agent

The enantiomeric purity and absolute configuration of flavanones were first determined using (<i>S</i>)-3,3′-dibromo-1,1′-bi-2-naphthol as a chiral solvating agent by means of ¹H NMR spectroscopy. The enantiomeric purity results closely matched those based on chiral HPLC analysis

Interaction modes of ursolic acid (A) and astragaloside IV (B) with HNE.

<p>For each ligand (blue), a putative binding mode from molecular docking calculations was prepared using PyMol. The important residues for ligand–NE hydrophobic interactions are represented by yellow rod-like structures and hydrogen bonding interactions are represented by gray rod-like structures. Hydrogen bonds are represented by black dotted lines.</p

Anti-HNE activity of six selected pentacyclic triterpenes (mean ± SD), n = 3.

<p>Inhibitory ratios are expressed as mean ± standard error.</p>*<p>P<0.05 vs. the control group.</p>**<p>P<0.01 vs. the control group.</p