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Nerve-targeted probes for fluorescence-guided intraoperative imaging.
A fundamental goal of many surgeries is nerve preservation, as inadvertent injury can lead to patient morbidity including numbness, pain, localized paralysis and incontinence. Nerve identification during surgery relies on multiple parameters including anatomy, texture, color and relationship to surrounding structures using white light illumination. We propose that fluorescent labeling of nerves can enhance the contrast between nerves and adjacent tissue during surgery which may lead to improved outcomes. Methods: Nerve binding peptide sequences including HNP401 were identified by phage display using selective binding to dissected nerve tissue. Peptide dye conjugates including FAM-HNP401 and structural variants were synthesized and screened for nerve binding after topical application on fresh rodent and human tissue and in-vivo after systemic IV administration into both mice and rats. Nerve to muscle contrast was quantified by measuring fluorescent intensity after topical or systemic administration of peptide dye conjugate. Results: Peptide dye conjugate FAM-HNP401 showed selective binding to human sural nerve with 10.9x fluorescence signal intensity (1374.44 ± 425.96) compared to a previously identified peptide FAM-NP41 (126.17 ± 61.03). FAM-HNP401 showed nerve-to-muscle contrast of 3.03 ± 0.57. FAM-HNP401 binds and highlight multiple human peripheral nerves including lower leg sural, upper arm medial antebrachial as well as autonomic nerves isolated from human prostate. Conclusion: Phage display has identified a novel peptide that selectively binds to ex-vivo human nerves and in-vivo using rodent models. FAM-HNP401 or an optimized variant could be translated for use in a clinical setting for intraoperative identification of human nerves to improve visualization and potentially decrease the incidence of intra-surgical nerve injury
Algorithms for Highly Symmetric Linear and Integer Programs
This paper deals with exploiting symmetry for solving linear and integer
programming problems. Basic properties of linear representations of finite
groups can be used to reduce symmetric linear programming to solving linear
programs of lower dimension. Combining this approach with knowledge of the
geometry of feasible integer solutions yields an algorithm for solving highly
symmetric integer linear programs which only takes time which is linear in the
number of constraints and quadratic in the dimension.Comment: 21 pages, 1 figure; some references and further comments added, title
slightly change
IR and UV Galaxies at z=0.6 -- Evolution of Dust Attenuation and Stellar Mass as Revealed by SWIRE and GALEX
We study dust attenuation and stellar mass of star-forming
galaxies using new SWIRE observations in IR and GALEX observations in UV. Two
samples are selected from the SWIRE and GALEX source catalogs in the
SWIRE/GALEX field ELAIS-N1-00 ( deg). The UV selected sample
has 600 galaxies with photometric redshift (hereafter photo-z) and NUV (corresponding to \rm L_{FUV} \geq 10^{9.6} L_\sun).
The IR selected sample contains 430 galaxies with mJy
(\rm L_{dust} \geq 10^{10.8} L_\sun) in the same photo-z range. It is found
that the mean ratios of the z=0.6 UV galaxies are
consistent with that of their z=0 counterparts of the same . For
IR galaxies, the mean ratios of the z=0.6 LIRGs (\rm
L_{dust} \sim 10^{11} L_\sun) are about a factor of 2 lower than local LIRGs,
whereas z=0.6 ULIRGs (\rm L_{dust} \sim 10^{12} L_\sun) have the same mean
ratios as their local counterparts. This is consistent
with the hypothesis that the dominant component of LIRG population has changed
from large, gas rich spirals at z to major-mergers at z=0. The stellar
mass of z=0.6 UV galaxies of \rm L_{FUV} \leq 10^{10.2} L_\sun is about a
factor 2 less than their local counterparts of the same luminosity, indicating
growth of these galaxies. The mass of z=0.6 UV lunmous galaxies (UVLGs: \rm
L_{FUV} > 10^{10.2} L_\sun) and IR selected galaxies, which are nearly
exclusively LIRGs and ULIRGs, is the same as their local counterparts.Comment: 27 pages, 8 figures, to be published in the Astrophysical Journal
Supplement series dedicated to GALEX result
UV and FIR selected star-forming galaxies at z=0: differences and overlaps
We study two samples of local galaxies, one is UV (GALEX) selected and the
other FIR (IRAS) selected, to address the question whether UV and FIR surveys
see the two sides ('bright' and 'dark') of the star formation of the same
population of galaxies or two different populations of star forming galaxies.
No significant difference between the L () luminosity
functions of the UV and FIR samples is found. Also, after the correction for
the `Malmquist bias' (bias for flux limited samples), the FIR-to-UV ratio v.s.
L relations of the two samples are consistent with each other. In the
range of 9 \la \log(L_{tot}/L_\sun) \la 12, both can be approximated by a
simple linear relation of \log (L_{60}/L_{FUV})=\log(L_{tot}/L_\sun)-9.66.
These are consistent with the hypothesis that the two samples represent the
same population of star forming galaxies, and their well documented differences
in L and in FIR-to-UV ratio are due only to the selection effect. A
comparison between the UV luminosity functions shows marginal evidence for a
population of faint UV galaxies missing in the FIR selected sample. The
contribution from these 'FIR-quiet' galaxies to the overall UV population is
insignificant, given that the K-band luminosity functions (i.e. the stellar
mass functions) of the two samples do not show any significant difference.Comment: 21 pages, 7 figures. Accepted by Ap
Spin Tunneling and Phonon-assisted Relaxation in Mn12-acetate
We present a comprehensive theory of the magnetization relaxation in a
Mn12-acetate crystal in the high-temperature regime (T>1 K), which is based on
phonon-assisted spin tunneling induced by quartic magnetic anisotropy and weak
transverse magnetic fields. The overall relaxation rate as function of the
longitudinal magnetic field is calculated and shown to agree well with
experimental data including all resonance peaks measured so far. The Lorentzian
shape of the resonances, which we obtain via a generalized master equation that
includes spin tunneling, is also in good agreement with recent data. We derive
a general formula for the tunnel splitting energy of these resonances. We show
that fourth-order diagonal terms in the Hamiltonian lead to satellite peaks. A
derivation of the effective linewidth of a resonance peak is given and shown to
agree well with experimental data. In addition, previously unknown spin-phonon
coupling constants are calculated explicitly. The values obtained for these
constants and for the sound velocity are also in good agreement with recent
data. We show that the spin relaxation in Mn12-acetate takes place via several
transition paths of comparable weight. These transition paths are expressed in
terms of intermediate relaxation times, which are calculated and which can be
tested experimentally.Comment: 18 pages, 22 EPS figures, REVTe
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