Effect of tube type on serum metabolites.

<p>Stars in boxplots indicate significant differences in concentration between methionine sulfoxide in serum W tubes with clotting activator and serum gel-barrier tubes. (Friedman test, significance level p<0.01).</p

Stability of metabolites in plasma during shipment simulation.

<p>Example of (A), (D) decreasing and (B), (C) increasing metabolite concentration of plasma samples at room temperature (RT) and on cool packs (CP). Stars in boxplots indicate significant difference in concentration compared to baseline (0 h). (Wilcoxon signed rank test, significance level p<0.01).</p

Impact of transportation simulation on metabolite concentrations in serum samples.

<p>* Metabolites with coefficient of variance across all plates above 25% in reference samples.</p><p>Metabolites that showed significant changes in serum concentration on cool packs for 3, 6 or 24 h compared to baseline (0 h) (Friedman test, p<0.01) and acceptable delay time for each metabolite during transportation (Wilcoxon signed rank test, p<0.01).</p

Stability of metabolites in serum during shipment simulation.

<p>Example of (A)-(C) increasing and (D) decreasing metabolite concentration during transportation simulation of serum samples on cool packs (CP). Stars in boxplots indicate significant difference in concentration compared to baseline (0 h). (Wilcoxon signed rank test, significance level p<0.01).</p

Median ICC with confidence intervals of serum metabolites.

<p>(A) Metabolites with median ICC-values below 0.65 and (B) metabolites with median ICC values above 0.65 are displayed.</p