Positive tipping points in a rapidly warming world

The challenge of meeting the UNFCCC CoP21 goal of keeping global warming ‘well below 2 °C and to pursue efforts towards 1.5 °C’ (‘the 2–1.5 °C target’) calls for research efforts to better understand the opportunities and constraints for fundamental transformations in global systems dynamics which currently drive the unsustainable and inequitable use of the Earth's resources. To this end, this research reviews and introduces the notion of positive tipping points as emergent properties of systems–including both human capacities and structural conditions — which would allow the fast deployment of evolutionary-like transformative solutions to successfully tackle the present socio-climate quandary. Our research provides a simple procedural synthesis to help identify and coordinate the required agents’ capacities to implement transformative solutions aligned with such climate goal in different contexts. Our research shows how to identify the required capacities, conditions and potential policy interventions which could eventually lead to the emergence of positive tipping points in various social–ecological systems to address the 2–1.5 °C policy target. Our insights are based on the participatory downscaling of global Shared Socio-economic Pathways (SSPs) to Europe, the formulation of pathways of solutions within these scenarios and the results from an agent-based economic modelling

One transition, many transitions? A corpus-based study of societal sustainability transition discourses in four civil society’s proposals

When the civil society makes ‘transition’ its label, it cannot be assumed that different civil society actors share compatible varieties of localist or radical transformationists discourses. This study has comparatively analyzed the discourses in four civil society sustainability transition proposals using a corpus-based methodology. We found that the proposals are similar as they identify the economy as an object and an entry point for transition, frame the economy as embedded in the socio–ecological system, ascribe agency to grassroots movements for transitions from the bottom–up. We also found crucial differences among the discourses regarding the role of the State, the degree of reform or radical innovation, the degree of imaginative character of the sustainability vision, the degree of opposition to capitalism. We suggest that insights on how the civil society employs notions of transition with respect to the themes of politics, emotions and place can help advance theorizations and practices of societal sustainability transitions led by the civil society

Transformative innovation and translocal diffusion

This paper develops a conceptual understanding of transformative innovations as shared activities, ideas and objects across locally rooted sustainability initiatives that explore and develop alternatives to incumbent and (perceived) unsustainable regimes that they seek to challenge, alter or replace. We synthesize empirical work from two European research projects (TRANSIT and ARTS), in which initiatives and networks were empirically studied, to develop a broader conceptual understanding of the emergence of transformative innovation. The development of initiatives can occur through growing, replicating, partnering, instrumentalising and embedding. This is supported through translocal networks that connect initiatives by sharing ideas, objects and activities across local contexts. This translocal characteristic of transformative innovations harnesses an enormous potential for sustainability transitions, but requires further understanding a

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Sustainable Urban Systems: Co-design and Framing for Transformation

Rapid urbanisation generates risks and opportunities for sustainable development. Urban policy and decision makers are challenged by the complexity of cities as social–ecological–technical systems. Consequently there is an increasing need for collaborative knowledge development that supports a whole-of-system view, and transformational change at multiple scales. Such holistic urban approaches are rare in practice. A co-design process involving researchers, practitioners and other stakeholders, has progressed such an approach in the Australian context, aiming to also contribute to international knowledge development and sharing. This process has generated three outputs: (1) a shared framework to support more systematic knowledge development and use, (2) identification of barriers that create a gap between stated urban goals and actual practice, and (3) identification of strategic focal areas to address this gap. Developing integrated strategies at broader urban scales is seen as the most pressing need. The knowledge framework adopts a systems perspective that incorporates the many urban trade-offs and synergies revealed by a systems view. Broader implications are drawn for policy and decision makers, for researchers and for a shared forward agenda

Just Sustainability Transitions:Politics, Power, and Prefiguration in Transformative Change Toward Justice and Sustainability

Facing the world's ecological, economic, and social challenges requires us to connect the concepts of justice, sustainability, and transitions. Bridging and discussing heterogeneous fields, we argue that these concepts need to complement each other, and we present just sustainability transitions (JUSTRAs) to do so. To define JUSTRAs, we review the state-of-theart literature, focusing on the understanding of these three concepts and their pairings in various disciplinary fields and empirical settings (e.g., environmental justice, just transitions, sustainability transitions, energy justice, food justice, urban justice). We center marginalized voices to highlight the processes of radical transformative change that JUSTRAs seek. We offer three analytical lenses that further the understanding of JUSTRAs: politics, power, and prefiguration. We argue that these complementary lenses are necessary to remake the world in both critical and pragmatic ways. Finally, we present a research agenda on JUSTRAs, foregrounding three complementary modes of inquiry: analyzing, critiquing, designing

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial.

Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled between December 2017 and September 2019. Patients were randomized to receive 1 gr of clarithromycin or placebo intravenously once daily for 4 consecutive days. The primary endpoint was 28-day all-cause mortality. Secondary outcomes were 90-day mortality; sepsis response (defined as at least 25% decrease in SOFA score by day 7); sepsis recurrence; and differences in peripheral blood cell populations and leukocyte transcriptomics. Fifty-five patients were allocated to each arm. By day 28, 27 (49.1%) patients in the clarithromycin and 25 (45.5%) in the placebo group died (risk difference 3.6% [95% confidence interval (CI) - 15.7 to 22.7]; P = 0.703, adjusted OR 1.03 [95%CI 0.35-3.06]; P = 0.959). There were no statistical differences in 90-day mortality and sepsis response. Clarithromycin was associated with lower incidence of sepsis recurrence (OR 0.21 [95%CI 0.06-0.68]; P = 0.012); significant increase in monocyte HLA-DR expression; expansion of non-classical monocytes; and upregulation of genes involved in cholesterol homeostasis. Serious and non-serious adverse events were equally distributed. Clarithromycin did not reduce mortality among patients with sepsis with respiratory and multiple organ dysfunction. Clarithromycin was associated with lower sepsis recurrence, possibly through a mechanism of immune restoration. Clinical trial registration clinicaltrials.gov identifier NCT03345992 registered 17 November 2017; EudraCT 2017-001056-55

The relational shift in urban ecology: from place and structures to multiple modes of coproduction for positive urban futures

This perspective emerged from ongoing dialogue among ecologists initiated by a virtual workshop in 2021. A transdisciplinary group of researchers and practitioners conclude that urban ecology as a science can better contribute to positive futures by focusing on relationships, rather than prioritizing urban structures. Insights from other relational disciplines, such as political ecology, governance, urban design, and conservation also contribute. Relationality is especially powerful given the need to rapidly adapt to the changing social and biophysical drivers of global urban systems. These unprecedented dynamics are better understood through a relational lens than traditional structural questions. We use three kinds of coproduction—of the social-ecological world, of science, and of actionable knowledge—to identify key processes of coproduction within urban places. Connectivity is crucial to relational urban ecology. Eight themes emerge from the joint explorations of the paper and point toward social action for improving life and environment in urban futures