Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Validating the Use of Rectus Muscle Fragment Welding to Control Presacral Bleeding During Rectal Mobilization

The incidence of presacral bleeding during rectal mobilization is low, but such bleeding may be massive and even fatal. Haemostasis can be difficult to achieve using conventional methods because of the complex interlacing of the venous network at the sacral periosteum. Historically, pelvic packing and metallic thumbtacks have been the more commonly used methods in our institution. However, the need for repeat surgery to remove the packs and the difficulties encountered in tack application have forced us to explore other methods. In 1994, the procedure termed muscle fragment welding, which uses electrocautery through a rectus muscle fragment, was introduced to control presacral bleeding. From January 1999 to February 2002, six of 416 patients undergoing pelvic surgery in our institution developed massive presacral haemorrhage and, therefore, this technique was used. Haemostasis was immediate and permanent. No major untoward postoperative events such as re-bleeding or infection were noted. One case developed a second-degree burn in the right elbow due to a misplaced ground conduction plate. Rectus muscle fragment welding is, in our experience, an effective and practical method of controlling presacral haemorrhage

Randomized Controlled Trial to Determine the Effectiveness of the Nivatvongs Technique Versus Conventional Local Anaesthetic Infiltration for Outpatient Haemorrhoidectomy

BackgroundConventional local anaesthesia in outpatient haemorrhoidectomy, using a diamond-shaped perianal block, is reliable, safe and inexpensive. It allows for early ambulation and short hospital stay. However, without sedation, local infiltration is perceived to be both uncomfortable and painful. Nivatvongs described a technique in which the anaesthetic is injected intra-anally into the insensitive area above the dentate line, allegedly causing less pain.MethodsThis randomized, controlled, parallel-group, single-blind clinical trial compared the effectiveness of the conventional and Nivatvongs techniques in reducing the pain of anaesthetic infiltration in adult patients undergoing outpatient haemorrhoidectomy. A total of 112 patients were randomized into either treatment (n = 57) or control groups (n = 55). Assigned surgeon-anaesthetists performed the local anaesthetic infiltration. The Milligan-Morgan technique was used for haemorrhoidectomy. Pain was assessed using a standardized visual analogue scale. Patient and surgeon satisfaction were measured with a pre-validated questionnaire.ResultsMedian scores for pain assessment during local anaesthetic infiltration were 2 and 3 in the control and treatment groups, respectively. Patient satisfaction with the method of anaesthetic infiltration and the procedure itself were 3 and 2, respectively, for both groups. The surgeon's overall satisfaction with the technique of anaesthetic infiltration was similar in the two groups. There was no significant difference in any of the outcomes measured.ConclusionBoth local anaesthetic techniques for outpatient haemorrhoidectomy were generally effective and well tolerated. The Nivatvongs technique did not confer any significant additional benefit

Attenuated familial adenomatous polyposis presenting as an abdominal wall mass

A case is discussed involving a 25-year-old female with attenuated familial adenomatous polyposis that presented as an abdominal wall mass. The patient eventually underwent a restorative proctocolectomy with ileal pouch anal anastomosis. [Arch Clin Exp Surg 2017; 6(1.000): 53-55

Por el excelentissimo señor duque de Medina-Coeli ... en exclusion del pretendido derecho de reversion à la Corona ... y en exclusion assimismo de la demanda, que puso el Conde de la Gomera ... y oy sigue su hermano don Estevan de Herrera Ayala y Roxas ... : sobre la succession de el estado, y mayorazgo de las villas de Gumièl de Mercado, Villo-Vela, Valde-Esgueba, y demás à èl perteneciente, que vacò por muerte de el Duque don Luis Francisco de la Zerda ...

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