Genome-wide association study using haplotype libraries and repeated-measures model to identify candidate genomic regions for stillbirth in Holstein cattle

© 2022, The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).[EN] Reduced fertility is one of the main causes of economic losses on dairy farms, resulting in economic losses estimated at $938 per stillbirth case in Holstein herds. The identification of genomic regions associated with stillbirth could help to develop better management and breeding strategies aimed to reduce the frequency of undesirable gestation outcomes. Here, 10,570 cows and 50,541 birth records were used to perform a haplotype-based GWAS. A total of 41 significantly associated pseudo-SNPs (haplotypes within haplotype blocks converted to a binary classification) were identified after Bonferroni adjustment for multiple tests. A total of 117 positional candidate genes were annotated within or close (in a 200-kb interval) to significant pseudo-SNPs (haplotype blocks). The guilt-by-association functional prioritization identified 31 potential functional candidate genes for reproductive performance out of the 117 positional candidate genes annotated. These genes play crucial roles in biological processes associated with pregnancy persistence, fetus development, immune response, among others. These results helped us to better understand the genetic basis of stillbirth in dairy cattle and may be useful for the prediction of stillbirth in Holstein cattle, helping to reduce the related economic losses caused by this phenotypeSIThe authors acknowledge the funding for this study, which was supported by the Ontario Ministry of Agriculture, Food, and Rural Affairs (OMAFRA, Ontario, Canada), Ontario Ministry of Research and Innovation, Agriculture and Agri-Food Canada (AAFC, Ontario, Canada), and Natural Sciences and Engineering Research Council of Canada (NSERC, Ontario, Canada) Discovery Grant. This study (FDE.13.17) was also supported by the Sustainable Beef and Forage Science Cluster (Alberta, Canada) funded by the Canadian Beef Cattle Check-Off, Beef Cattle Research Council (BCRC), Alberta Beef Producers, Alberta Cattle Feeders' Association, Beef Farmers of Ontario, La Federation des Productuers de bovins du Quebec, and AAFC's Canadian Agricultural Partnership. This study is a part of the Food from Thought research program at the University of Guelph, which is funded in part by the Canada First Research Excellence Fund. The authors have not stated any conflicts of interes

Effects of consumption of galactooligosaccharides obtained through whey enzymatically modified on the faecal flora and nutritional parameters of hamsters

The aim of this research was to evaluate the influence of wheyenzymatically modified rich in galactooligosaccharides in thenutritional characteristics and effects in the microflora of cecumcontents by the study with Golden Syrian hamsters (Mesocricetusauratus) for 28 days (controlled conditions). Three isoproteic dietswere prepared (20% w/w): C (casein), W (whey) and G (wheymodified). The groups studied differed positively from the C regardingfeed and protein efficiency ratio. The relationships (w/w) oforgan/body were found proportional in all diets. The counts ofprobiotics from the cecum contents the groups showed no difference.The pHs of studied groups were lower than C, this acidity can atimpairs the ability of pathogens to grow in the intestine. Resultssuggest that using whey enzymatically modified rich ingalactooligosaccharides could replace the standard diet withnutritional efficiency and possible inhibit the microorganismspathogenic without induce damage in health.Fil: Dos Santos Da Fonseca, Renata Aline. Universidade Federal Do Rio Grande; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Rodrigues Machado, Adriana. Universidade Federal Do Rio Grande; BrasilFil: Muniz Moreira, Lidiane. Universidade Federal Do Rio Grande; BrasilFil: Rodrigues, Rosane S.. Universidade Federal de Pelotas; BrasilFil: Machado, Mirian. Universidade Federal de Pelotas; BrasilFil: Souza Soares, Leonor A.. Universidade Federal Do Rio Grande; BrasilFil: Burkert, Carlos André V.. Universidade Federal Do Rio Grande; BrasilFil: Burkert, Janaína Fernandes de Medeiros. Universidade Federal Do Rio Grande; Brasi

BRSMT Vencedora: cultivar semiprecoce de arroz de terras altas.

A BRSMT Vencedora é uma cultivar de produtividade similar à das principais variedades em cultivo nas terras altas, porém, apresenta, em relação a cada uma delas, vantagens importantes que a transformam em uma opção de cultivo relevante. Esta cultivar está sendo recomendada para plantio nos Estados de Goiás, Minas Gerais, Mato Grosso do Sul, Mato Grosso, Roraima e Pará.bitstream/item/60526/1/Comt72.pd

Extensão de recomendação da cultivar de arroz de terras altas "BRS Soberana" para Goiás.

A BRS Soberana originou-se de um cruzamento triplo realizado pela Embrapa Arroz e Feijão, em 1990, envolvendo os genitores Cuiabana, CNAx 1235-8-3 e CNA 6673. A fim de compensar a redução da disponibilidade de sementes da BRS Primavera, a Embrapa Arroz e Feijão lançou uma nova cultivar de padrão próximo ao dela, a BRS Soberana, que se mostrara, inicialmente, melhor adaptada ao Estado do Mato Grosso.bitstream/CNPAF/21541/1/comt_73.pd

BRSMT Vencedora: cultivar semiprecoce de arroz de terras altas.

A BRSMT Vencedora é uma cultivar de produtividade similar à das principais variedades em cultivo nas terras altas, porém, apresenta, em relação a cada uma delas, vantagens importantes que a transformam em uma opção de cultivo relevante. Esta cultivar está sendo recomendada para plantio nos Estados de Goiás, Minas Gerais, Mato Grosso do Sul, Mato Grosso, Roraima e Pará.bitstream/CNPAF/21533/1/comt_72.pd