Arthur J. Yates (1882-1961) and His Collection of Lepidoptera

The fine collection of Michigan Lepidoptera assembled by the late Arthur J. Yates has recently been donated by his wife, Mrs. Ethel K. Yates, to the Entomology Museum of Michigan State University

Insects Taken at Japanese Beetle Traps Baited with Anethole-Eugenol in Southern Michigan in 1968

A survey of the populations of Jap.anese beetles, Popillia japonica Newman, is made each year in southern Michigan to determine the abundance and distribution of this pest insect. Since little information is available about the insects that are attracted by Japanese beetle attractants in Michigan or anywhere in the United States, a study was made of the insects captured in Japanese beetle traps

A Taxonomic and Ecological Study of the Asilidae of Michigan

Seventy-two species of Asilidae have been recorded from Michigan. An additional seven which may occur are included. Keys to subfamilies, genera and species are given. Two subfamilies and twenty-five genera are represented. A discussion of specific identification, habitat, and distribution is given where possible. The Laphria canis complex, index complex, and aeatus complex are discussed. One new species, Laphria calvescenta is described. Laphria disparella has been raised from synonymy. Machimus virginicus was removed from Asilus sensu-latu and placed in the genus Machimus

Isophotonic reactor for the precise determination of quantum yields in gas, liquid, and multi-phase photoreactions

Photocatalytic processes are an emerging field with a multitude of potential applications ranging from waste and wastewater treatment over fine chemical production to artificial photosynthesis. Knowing the quantum yield in a photoreaction is thereby essential to both, the selection of suitable photocatalysts and the design of optimized photoreactors. Nevertheless, the precise determination of quantum yields as function of the operating conditions is still a challenge without standardized and reliable procedures and apparatuses. Herein a novel approach for the accurate determination of quantum yields based on a tailored, 3D-printable photoreactor and 3D optical modelling is reported. Besides wavelength, temperature, and reactant concentration control, the unique optical design of an isophotonic reactor enables the control of the local volumetric rate of photon absorption to be homogeneous throughout the reaction volume. The validity of the approach is demonstrated by determining the quantum yield of the standard potassium ferrioxalate actinometer. Further, the adaptability to any gas, liquid, or multi-phase photoreaction is outlined by showcasing the ability of the approach with an exemplary aerogel-supported titania-based methanol reforming photocatalyst. The revealed subtlety and complex nature of the quantum yield in the methanol reforming system highlights the need for meticulous analysis and standardization of the determination of quantum yields and thereby underlines the value of the proposed approach. Software tools and print files provided alongside the publication facilitate adaptation and further development of the approach by researchers in the field

Late Quaternary aeolian dynamics, pedostratigraphy and soil formation in the North European Lowlands – new findings from the Baruther ice-marginal valley

The construction of dunes in central Europe reflects ample sediment supply during the last deglacial hemicycle. A Quaternary inland dune complex in southern Brandenburg, Germany, was studied to determine the duration of recent pedogenesis, from two outcrops, which show buried paleosols. An integrative approach, which combined geomorphological, sedimentological, (paleo-)pedological and chronological methods was used to identify aeolian deposition events, ensuing pedogenesis and anthropogenic remobilization. At the outcrops, which were situated approximately 2 km apart from each other, in total twelve samples of the aeolian sands were dated using optically stimulated luminescence (OSL) and six using 14C dating. Although the dunes have similar morphological features, these forms have a different history of aeolian sand deposition and pedogenesis. At the older dune (Gl 1) the surface soil is a well developed Podzol, whereas soil development of the younger dune (Gl 2) is clearly in an initial state. The two dunes also differ in grain size distribution and in the presence of buried soils, thereby indicating a climatic impact on aeolian remobilization

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

Tumor necrosis factor receptor 2 (TNFR2) is a transmembrane receptor that promotes immune modulation and tissue regeneration and is recognized as a potential therapeutic target for multiple sclerosis (MS). However, TNFR2 also contributes to T effector cell function and macrophage-TNFR2 recently was shown to promote disease development in the experimental autoimmune encephalomyelitis (EAE) model of MS. We here demonstrate that systemic administration of a TNFR2 agonist alleviates peripheral and central inflammation, and reduces demyelination and neurodegeneration, indicating that protective signals induced by TNFR2 exceed potential pathogenic TNFR2-dependent responses. Our behavioral data show that systemic treatment of female EAE mice with a TNFR2 agonist is therapeutic on motor symptoms and promotes long-term recovery from neuropathic pain. Mechanistically, our data indicate that TNFR2 agonist treatment follows a dual mode of action and promotes both suppression of CNS autoimmunity and remyelination. Strategies based on the concept of exogenous activation of TNFR2 therefore hold great promise as a new therapeutic approach to treat motor and sensory disease in MS as well as other inflammatory diseases or neuropathic pain conditions

The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization of TNF-α largely failed in the treatment of neurodegenerative diseases. TNF-α exerts distinct functions depending on interaction with its two TNF receptors, whereby TNF receptor 1 (TNFR1) is associated with neuroinflammation and apoptosis and TNF receptor 2 (TNFR2) with neuroprotection and immune regulation. Here, we investigated the effect of administering the TNFR1-specific antagonist Atrosimab, as strategy to block TNFR1 signaling while maintaining TNFR2 signaling unaltered, in an acute mouse model for neurodegeneration. In this model, a NMDA-induced lesion that mimics various hallmarks of neurodegenerative diseases, such as memory loss and cell death, was created in the nucleus basalis magnocellularis and Atrosimab or control protein was administered centrally. We showed that Atrosimab attenuated cognitive impairments and reduced neuroinflammation and neuronal cell death. Our results demonstrate that Atrosimab is effective in ameliorating disease symptoms in an acute neurodegenerative mouse model. Altogether, our study indicates that Atrosimab may be a promising candidate for the development of a therapeutic strategy for the treatment of neurodegenerative diseases

Perfusion Abnormalities on 24-Hour Perfusion Imaging in Patients With Complete Endovascular Reperfusion.

BACKGROUND Perfusion abnormalities in the infarct and salvaged penumbra have been proposed as a potential reason for poor clinical outcome (modified Rankin Scale score >2) despite complete angiographic reperfusion (Thrombolysis in Cerebral Infarction [TICI3]). In this study, we aimed to identify different microvascular perfusion patterns and their association with clinical outcomes among TICI3 patients. METHODS University Hospital Bern's stroke registry of all patients between February 2015 and December 2021. Macrovascular reperfusion was graded using the TICI scale. Microvascular reperfusion status was evaluated within the infarct area on cerebral blood volume and cerebral blood flow perfusion maps obtained 24-hour postintervention. Primary outcome was functional independence (90-day modified Rankin Scale score 0-2) evaluated with the logistic regression analysis adjusted for age, sex, and 24-hour infarct volume from follow-up imaging. RESULTS Based on microvascular perfusion findings, the entire cohort (N=248) was stratified into one of the 4 clusters: (1) normoperfusion (no perfusion abnormalities; n=143/248); (2) hyperperfusion (hyperperfusion on both cerebral blood volume and cerebral blood flow; n=54/248); (3) hypoperfusion (hypoperfusion on both cerebral blood volume and cerebral blood flow; n=14/248); and (4) mixed (discrepant findings, eg, cerebral blood volume hypoperfusion and cerebral blood flow hyperperfusion; n=37/248). Compared with the normoperfusion cluster, patients in the hypoperfusion cluster were less likely to achieve functional independence (adjusted odds ratio, 0.3 [95% CI, 0.1-0.9]), while patients in the hyperperfusion cluster tended to have better outcomes (adjusted odds ratio, 3.3 [95% CI, 1.3-8.8]). CONCLUSIONS In around half of TICI3 patients, perfusion abnormalities on the microvascular level can be observed. Microvascular hypoperfusion, despite complete macrovascular reperfusion, is rare but may explain the poor clinical course among some TICI3 patients, while a detrimental effect of hyperperfusion after reperfusion could not be confirmed