Bisphosphonates et ostéonécrose maxillo-mandibulaire : synthèse

peer reviewe

Successful Treatment of Spondylodiscitis and Infectious Sacroiliitis due to Listeria monocytogenes using Meropenem as Salvage Therapy

Infectious sacroiliitis is a rare disease that can occur in conjunction with other osteoarticular infections. Furthermore, it is very unusual for Listeria monocytogenes to be identified in an osteoarticular infection, with spondylodiscitis being the most frequent such infection. We report a case of spondylodiscitis with infectious sacroiliitis due to infection with L. monocytogenes treated successfully with meropenem as salvage therapy

Ressort d'orthodontie hélicoïdal et son procédé de fabrication

Les trois auteurs: Marie-Pierryle Filleul, Jean-Maxime Terrasse et George Olivier ont l'affiliation suivante: Faculté d'Odontologie de Nancy (Université de Lorraine)Ressort d'orthodontie hélicoïdal et son procédé de fabricatio

Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009

International audienceBACKGROUND: To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.METHODOLOGY/PRINCIPAL FINDINGS: A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥ 1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20-59 years) and 73.3% in the elderly (≥ 60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive.CONCLUSIONS: Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥ 1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses

ANCA-negative associated vasculitis initially presenting with pulmonary embolism

Antineutrophil-cytoplasm antibodies (ANCA)-associated vasculitis are severe inflammatory pathologies that, although rare, may induce significant morbidity or death. Their impact on multiple organ systems implies an important variability in their clinical presentation, which might delay the diagnosis. In this setting we report on a case of ANCA-negative-associated vasculitis, initially presenting as pulmonary embolism with severe pulmonary infarction and digestive involvement. Literature is then discussed on these complications and their implications for therapy.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Bisphosphonates et ostéonécrose maxillomandibulaire

Today, bisphosphonates are very frequently used to relieve patients suffering from various bone diseases, mainly bone metastases and osteoporosis. They have been associated with numerous cases of maxillar and mandibullar osteonecrosis, a severe affection characterized by a high morbidity and for which no consensual treatment has been found yet. After a short update, the authors reviewed indications for bisphosphonates and its pharmacological properties. The pathogenesis, predisposing factors, symptoms, and clinical evaluation of this particular necrosis are described. Preventive and therapeutic managements are suggested. © 2008 Elsevier Masson SAS. All rights reserved.SCOPUS: sh.jinfo:eu-repo/semantics/publishe

Bisphosphonate-induced osteonecrosis of the jaw: A review of 2,400 patient cases

Purpose Bisphosphonates (BPs) are bone-remodeling inhibitors that are used to manage bone metastases and osteoporosis. Osteonecrosis of the jaw, however, can occur during treatment. This complication is poorly understood and is called "bisphosphonate-induced osteonecrosis of the jaw"(BIOJ). Methods We performed a PubMed-based review of all of the described cases of BIOJ from January 2003 (the year of the first description) to September 2009. Issues of clinical relevance, such as the primary diagnosis and type of treatment, were evaluated for each patient case. Results We retrieved 2,408 cases, 88% of which were associated with intravenous therapy, primarily withzoledronate. Of the total number of cases, 89% wereassociated with the treatment of a malignant condition,particularly multiple myeloma (43% of the cases). Of all the BIOJ cases, 67% were preceded by tooth extraction andonly 35% of patients were cured.Conclusion Prevention is better than treatment, and the establishment of meticulous oral hygiene and surgicalprocedures prior to commencing BP treatment is important for preventing BIOJ. Our review summarizes the currentknowledge about this severe complication. Future studies,especially basic research studies, are needed to better understand this devastating disease. © Springer-Verlag 2010.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Etude de la corrosion et de l'usure des pinces à couper les ligatures au cours de la stérilisation

L'objectif est l'étude de la corrosion et de l'usure des pinces à couper les ligatures au cours des cycles de stérilisation en respectant les normes concernant l'inactivation du prion. Le matériel consiste en 3 lots de 25 pinces à couper les ligatures à mors rapportés provenant de 3 fournisseurs différents (Dentaurum®, ETM® et RMO®), du fil de ligature de diamètre .010 pouces, soit 0,25mm, en acier inoxydable, et enfin 5 produits de prédésinfection (Ampholysine Plus®, Elusept®, Dy Septi®, Prédolyse®, Dentasept Ultra®). Après caractérisation des pinces (étude de la composition, de la dureté, et de la structure) puis des produits de prédésinfection (étude de la composition et du pH) la susceptibilité à la corrosion de chaque partie de ces pinces a été analysée, avec réalisation de couplages galvaniques de ces différents éléments. Le comportement électrochimique des pinces dans leur globalité a été étudié par immersion dans les différents produits de prédésinfection, ainsi que l'usure et l'apparition de traces de corrosion, ceci au fur et à mesure des cycles de stérilisation. L'observation des pinces a mis en évidence de faibles modifications aussi bien en termes de corrosion que d'usure. Quelque soit la marque des pinces, ou le produit de prédésinfection, la résistance au cours des cycles de stérilisation est satisfaisante.The aim of this work was to assess the effect of sterilization on ligature-cutting pliers, and more specifically the corrosion and wear of the plier's cutting edges, while respecting prion inactivation norms. Material included one set of 25 ligature-cutting pliers supplied by three major orthodontic distributors (Dentaurum®, ETM® and RMO®), .010 inch stainless steel orthodontic ligature wire and five disinfecting agents (Ampholysine Plus®, Elusept®, Dy Septi®, Prédolyse®, Dentasept Ultra®). Pliers (chemical composition, Vickers hardness, crystalline network) and disinfecting agents (chemical composition, pH) were initially characterized. Corrosion susceptibility of each single part of the different pliers was then analyzed, and galvanic coupling performed. Electrochemical behaviors of the whole pliers were studied by immersion in the various disinfecting agents. The pliers corrosion and wear were also observed with increasing number of sterilization cycles. Resistance to corrosion during sterilization cycles was found to be satisfactory, all pliers and disinfecting agents included.NANCY1-Bib. numérique (543959902) / SudocSudocFranceF

Effect of socioeconomic status on the relationship between atmospheric pollution and mortality

Current knowledge about potential interactions between socioeconomic status and the short‐ and long‐term effects of air pollution on mortality was reviewed. A systematic search of the Medline database through April 2006 extracted detailed information about exposure measures, socioeconomic indicators, subjects' characteristics and principal results. Fifteen articles (time series, case‐crossover, cohort) examined short‐term effects. The variety of socioeconomic indicators studied made formal comparisons difficult. One striking fact emerged: studies using socioeconomic characteristics measured at coarser geographic resolutions (city‐ or county‐wide) found no effect modification, but those using finer geographic resolutions found mixed results, and five of six studies using individually‐measured socioeconomic characteristics found that pollution affected disadvantaged subjects more. This finding was echoed by the six studies of long‐term effects (cohorts) identified; these had substantial methodological differences, which we discuss extensively. Current evidence does not yet justify a definitive conclusion that socioeconomic characteristics modify the effects of air pollution on mortality. Nevertheless, existing results, most tending to show greater effects among the more deprived, emphasise the importance of continuing to investigate this topic

Incidence des cancers ORL en Belgique en regard des données mondiales et françaises

The squamous cell carcinomas of the upper aerodigestive tracts are frequent neoplasia, with as much as 466,831 and 168,368 cases diagnosed in 2008 among men and women worldwide, respectively. As such, they make up the sixth most frequent neoplasia among men and the eighth among women. Their frequency shows interesting variations covering the last 20 years, with an ascending tendency among women, which is higher in Europe, and a descending tendency in men, maximal in the USA. The comparison with the Belgian official data reveals a striking elevation of incidence of these cancers between both sexes, with important regional differences in Belgium. Finally, when we compare Belgian and French data, these cancers seem more frequent in France in men, but there is an opposite tendency among women, in which the carcinoma of the larynx is most represented in Belgium. Although the limited quality of the data limits the interpretation of these data, they seem to be partly in line with the evolution of the risk factors of these pathologies. ©John Libbey Eurotext.SCOPUS: ar.jinfo:eu-repo/semantics/publishe