Additional file 6: Figure S6. of Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Flow cytometric apoptosis assay. Dose-effect curves for leukemia cell lines treated with THC in a dose-dependent manner are shown. Student’s t-test analysis demonstrates significance (p < 0.05) of induction of apoptosis. Experiments were performed in triplicates. Methanol as drug carrier was applicated at the highest tested dose (left panels). Non-linear regression analysis was performed to compute IC50s (right panels). (TIFF 536 kb

Additional file 10: Figure S10. of Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Reduction of the viable leukemia population upon treatment with THC. Immunphenotyping of the leukemic clone in a FSC/SSC scatter plot was performed in a patient with refractory ALL and >90 % blasts in the peripheral blood. Reduction of the population was followed after exposure to THC for 48 h. Proportion of the remaining viable cell proportion is shown in a dose-effect plot. (TIFF 282 kb