Towards comprehensive characterisation and modelling of the forming and wrinkling mechanics of engineering fabrics

Through a combination of direct measurement and inverse modelling, a route to characterising the main mechanical forming properties of engineering fabric is demonstrated. The process involves just two experimental tests, a cantilever bending test and a modified version of the uniaxial bias extension test. The mechanical forming properties of a twill weave carbon fabric have been determined, including estimates of the in-plane bending stiffness and the torsional stiffness of a sheared fabric. As a result of measuring and incorporating all the main mechanical properties of the fabric in forming simulations (tensile, shear, out-of-plane bending, in-plane bending & torsion), the specimen size-dependent shear kinematics and wrinkling response measured in experiments, is faithfully reproduced in simulations of the uniaxial bias extension (UBE) test

On the impact of early marriage on schooling outcomes in sub-Saharan Africa and South West Asia

This paper examines the effect of age of marriage on women's schooling outcomes for 36 countries from Sub-Saharan Africa and South West Asia. We employ an instrumental variable approach to account for the endogeneity of early marriage driven by socio-economic and cultural factors. Our results show that delaying early marriage by one year is associated with an increase of half a year of education in Sub-Saharan Africa and nearly one third of a year of education in South West Asia as well as a lower likelihood of dropping out from secondary school of 5.5% in South West Asia

Monte Carlo model of the uncertainty of SEA loss factors

Finite Element Methods are widely used to model vibro-acoustic systems, but as the modal density becomes higher this type of model becomes inaccurate and impractical. This is why in the high modal density region the use of Statistical Energy Analysis (SEA) models has become increasingly popular. SEA has some obvious advantages such as its simple formal expression, being based on linear equation systems or the reduced number of variables involved. But SEA has drawbacks as well, such as the absence of local information or the necessity of frequency averaging. A key quantity in SEA models is the loss factor. This takes into account the energy dissipated within a given subsystem or when power flows from one subsystem to another. Even though analytical expressions exist for a number of subsystems of differing nature, the measurement of the loss factor is still advisable and a necessity for a large number of cases. The most commonly used method of measuring loss factors is the Power Injection Method. This method is based on the injection of power into every single subsystem in sequence while the energy in each subsystem is measured. In spite of its simplicity, there remain a number of problems where the accuracy of the results is influenced by various practical issues. In this paper, a Monte Carlo model is used to describe the uncertainty of a two subsystemproblem consisting of two planar elements connected along one side. The influence of the input variables is studied and the conditioning of the coefficient matrix that model the system is also taken into accoun

Qubit authentication

Secure communication requires message authentication. In this paper we address the problem of how to authenticate quantum information sent through a quantum channel between two communicating parties with the minimum amount of resources. Specifically, our objective is to determine whether one elementary quantum message (a qubit) can be authenticated with a key of minimum length. We show that, unlike the case of classical-message quantum authentication, this is not possible.Comment: LaTeX, 8 page

Application of Pyridazinediones in the Construction of Self-Immolative Scaffolds for Potential Use in Small Molecule–Drug Conjugates

Cancer constitutes one of the leading causes of death worldwide and research in this field is constantly aiming to discover and develop ever more efficient ways in which to treat and manage this disease. For much of the 20th century the leading strategy has been that of chemotherapy: a treatment invariably accompanied by undesirable side effects due to its lack of specificity. The field has therefore moved towards targeted-drug delivery, with antibody–drug conjugates (ADCs) having established themselves in this area with great success. Less work however has been undertaken on small molecule–drug conjugates (SMDCs) and this thesis describes the design of SMDC precursors based on the pyridazinedione (PD) molecule, as well as the development of a novel, sulfur-based self-immolative linker which could enable the attachment of drugs and fluorophores to such a construct. The first primary focus of this work centres around the PD core’s thiol reactive centres, with the exploration of whether thioaryl- or thioalkyl-PDs fare better when subjected to human serum- and tumour cell-mimicking conditions. It was found that a bis-thioaryl PD performed best, and its aromatic thiol substituents were subsequently derivatised for the purpose of attaching a fluorophore via a novel, sulfur-based self-immolative linker. The release of the fluorophore seen by LC-MS and the turn-on fluorescence observed by fluorescence spectroscopy both confirmed the self-degradative mechanism of this linker. The second primary objective of this work was to then install groups that are relevant to an SMDC precursor onto the N-handles of the PD core, culminating in the successful isolation of di-bromo PEG azide and PEG alkyne PDs. The latters’ bromine positions were then substituted with a derivatisable thiol to demonstrate that incorporating three distinct groups onto the same PD platform is possible, thus vindicating its versatility and modularity. Consequently, novel SMDC precursors have been synthesised whose functional groups have potential for future attachment of fluorophores, drugs and tumour-targeting ligands

Emerging actions of the nuclear receptor LRH-1 in the gut

AbstractLiver receptor homolog-1 (NR5A2) is a nuclear receptor originally identified in the liver and mostly known for its regulatory role in cholesterol and bile acid homeostasis. More recently, liver receptor homolog-1 has emerged as a key regulator of intestinal function, coordinating unanticipated actions, such as cell renewal and local immune function with important implications to common intestinal diseases, including colorectal cancer and inflammatory bowel disease. Unlike most of the other nuclear receptors, liver receptor homolog-1 acts as a constitutively active transcription factor to drive the transcription of its target genes. Liver receptor homolog-1 activity however is to a major extent regulated by different corepressors and posttranslational modifications, which may account for its tissue-specific functions. This review will provide an update on the molecular aspects of liver receptor homolog-1 action and focus on some emerging aspects of its function in normal and diseased gut. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease

Air gap influence on the vibro-acoustic response of Solar Arrays during launch

One of the primary elements on the space missions is the electrical power subsystem, for which the critical component is the solar array. The behaviour of these elements during the ascent phase of the launch is critical for avoiding damages on the solar panels, which are the primary source of energy for the satellite in its final configuration. The vibro-acoustic response to the sound pressure depends on the solar array size, mass, stiffness and gap thickness. The stowed configuration of the solar array consists of a multiple system composed of structural elements and the air layers between panels. The effect of the air between panels on the behaviour of the system affects the frequency response of the system not only modifying the natural frequencies of the wings but also as interaction path between the wings of the array. The usual methods to analyze the vibro-acoustic response of structures are the FE and BE methods for the low frequency range and the SEA formulation for the high frequency range. The main issue in the latter method is, on one hand, selecting the appropriate subsystems, and, on the other, identifying the parameters of the energetic system: the internal and coupling loss factors. From the experimental point of view, the subsystems parameters can be identified by exciting each subsystem and measuring the energy of all the subsystems composing the Solar Array. Although theoretically possible, in practice it is difficult to apply loads on the air gaps. To analyse this situation, two different approaches can be studied depending on whether the air gaps between the panels are included explicitly in the problem or not. For a particular case of a solar array of three wings in stowed configuration both modelling philosophies are compared. This stowed configuration of a three wing solar arrays in stowed configuration has been tested in an acoustic chamber. The measured data on the solar wings allows, in general, determining the loss factors of the configuration. The paper presents a test description and measurements on the structure, in terms of the acceleration power spectral density. Finally, the performance of each modelling technique has been evaluated by comparison between simulations with experimental results on a spacecraft solar array and the influence on the apparent properties of the system in terms of the SEA loss factors has been analyse

Definition of a labelling code for the noise emitted by machines

It has been increasingly realised that traditional parameters, such as A-weighted sound levels, sound power and noise spectra in octaves or third octaves are not enough to describe a sound and that machine labels should show more subjective information about the emitted noise. A new labelling system based on empirical data is proposed. The methodology of the study used as the basis for the proposal is explained, as well as the objective and subjective characteristics to be included in the new label. The uses and applications of the label are discussed briefly

La Ingeniería Divertida: Gravity Challenge.

La competición se utiliza en muchos entornos educativos, especialmente en el ámbito anglosajón, como medio para contribuir al desarrollo de las habilidades de los alumnos, aspecto este que se encuentra íntimamente ligado a la adquisición de determinadas competencias profesionales. En el sector de la ingeniería y arquitectura resulta de gran importancia y por ello, la Universidad Politécnica de Madrid ha organizado durante el curso 2006‐07 un conjunto de competiciones de estudiantes muy diversas. Una de estas competiciones es la denominada GRAVITY CHALLENGE, en la que los equipos participantes se enfrentaban al reto de lanzar un huevo desde una altura de 15 metros y conseguir que aterrice en el suelo sin romperse. Los equipos ganadores serían aquellos que lograsen este objetivo de la forma más creativa. En este trabajo se describe el procedimiento seguido para la organización de esta competición en la que participaron 27 equipos de distintas universidades. También se presentan los resultados y se hace una reflexión sobre los objetivos formativos que consideramos alcanzados