Re-drawing existing powers over natural resources for food security at the light of a natural resources constrained world

7 pagesInternational audienceFood security is inextricably dependent both on the availability and on the access to natural resources necessary for food production (land, water, seeds and others). The availability of these resources is in turn inevitably linked to the capacity of the Earth to produce food, and thus to the maintenance of the Earth's life-support systems. However, the maintenance of this capacity and of the systems on which it depends is clearly endangered by human activities and by the current forms of using natural resources

Définitions des ressources naturelles et implications pour la démarche juridique

Contribution publiée in Penser une démocratie alimentaire Volume II – Proposition Lascaux entre ressources naturelles et besoins fondamentaux, F. Collart Dutilleul et T. Bréger (dir), Inida, San José, 2014, pp. 71-77International audienceLa construction d’un droit dédié aux ressources naturelles nécessite de s’accorder préalablement sur les notions clés. A cet égard, les choix effectués ne seront pas indifférents ou dépourvus de conséquences : ils reflètent les valeurs considérées comme fondamentales dans nos sociétés. Bien que les choix de vocabulaire soient essentiellement des choix politiques, nous soutenons que le concept légal de « ressources naturelles » devrait satisfaire aux objectifs de maintien des systèmes supportant la vie sur Terre et de satisfaction des besoins fondamentaux humains

APC selectively mediates response to chemotherapeutic agents in breast cancer

BACKGROUND: The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70 % of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the Apc(Min/+) mouse crossed to the Polyoma middle T antigen (PyMT) transgenic model, we identified enhanced breast tumorigenesis and alterations in genes critical in therapeutic resistance independent of Wnt/β-catenin signaling. Apc mutation changed the tumor histopathology from solid to squamous adenocarcinomas, resembling the highly aggressive human metaplastic breast cancer. Mechanistic studies in tumor-derived cell lines demonstrated that focal adhesion kinase (FAK)/Src/JNK signaling regulated the enhanced proliferation downstream of Apc mutation. Despite this mechanistic information, the role of APC in mediating breast cancer chemotherapeutic resistance is currently unknown. METHODS: We have examined the effect of Apc loss in MMTV-PyMT mouse breast cancer cells on gene expression changes of ATP-binding cassette transporters and immunofluorescence to determine proliferative and apoptotic response of cells to cisplatin, doxorubicin and paclitaxel. Furthermore we determined the added effect of Src or JNK inhibition by PP2 and SP600125, respectively, on chemotherapeutic response. We also used the Aldefluor assay to measure the population of tumor initiating cells. Lastly, we measured the apoptotic and proliferative response to APC knockdown in MDA-MB-157 human breast cancer cells after chemotherapeutic treatment. RESULTS: Cells obtained from MMTV-PyMT;Apc(Min/+) tumors express increased MDR1 (multidrug resistance protein 1), which is augmented by treatment with paclitaxel or doxorubicin. Furthermore MMTV-PyMT;Apc(Min/+) cells are more resistant to cisplatin and doxorubicin-induced apoptosis, and show a larger population of ALDH positive cells. In the human metaplastic breast cancer cell line MDA-MB-157, APC knockdown led to paclitaxel and cisplatin resistance. CONCLUSIONS: APC loss-of-function significantly increases resistance to cisplatin-mediated apoptosis in both MDA-MB-157 and the PyMT derived cells. We also demonstrated that cisplatin in combination with PP2 or SP600125 could be clinically beneficial, as inhibition of Src or JNK in an APC-mutant breast cancer patient may alleviate the resistance induced by mutant APC. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1456-x) contains supplementary material, which is available to authorized users

Evaluation of the quality of Quickbird fused products

International audienceMost of the satellite sensors, presently operating in the optical domain, are providing a data set comprising multispectral images at a low spatial resolution and images at a higher spatial resolution but with a lower spectral content. The trend of satellite sensors is similar to the present situation. The idea of fusing multispectral images with a highest spatial resolution enables the creation of useful products for a set of applications. This paper aims at evaluating a set of methods for construction of synthetic multispectral images having a highest spatial resolution available within the data set. These methods are evaluated through the construction of fused products from a set of Quickbird panchromatic and multispectral images. Of interest are the most used methods: the Intensity-Hue-Saturation method, the Brovey transform, the multiplicative methods and a set of methods derived from the ARSIS concept. The different methods are shortly presented. These methods are tested in a dataset from the area of Madrid. The dataset proposed a good diversity of landscape allowing the measure of the impact of fusion methods on different cases. The resulting images are evaluated through visual criteria from a set of photointerpreters. They classified the fused products and pro-vided a ranking for the visual quality. Then the proposed protocol defined by Wald et al. (1997) is applied to all methods. A set of quantitative parameters is computed allowing an objective comparison of the results. Finally a new parameter allowing the quantification of the information brought by the fusion method is proposed. This parameter is based on the analysis of the difference of the real structures of a multispectral image and of the computed structures of the fused products. It is applied to the different methods and favors the evaluation of the impact of an algorithm on the resulting images. Some conclusions are drawn on the ranking of the different methods and on the appropriate parameters for the evaluation of the quality of fused products

A Natural Resource-Systems approach: Targeting the Ecological Transition at the Regional Scale

Chapitre de l’ouvrage collectif Penser une démocratie alimentaire Volume II – Proposition Lascaux entre ressources naturelles et besoins fondamentaux, F. Collart Dutilleul et T. Bréger (dir), Inida, San José, 2014, pp. 143-167.International audienceHuman history can be mirrored in a geo-history of natural resources. Humans, by over-exploiting resources (“forcing”), have produced extensive land use changes and have altered complex food webs, ecosystems, and habitats with as a consequence systematic natural biocapacity erosion, biodiversity loss, energy crises, pollution, climate deregulation. In other terms, a global resources “rush” has led to chronic socio-ecosystemic deficits, thus creating the conditions for local and global state shifts within the biosphere and / or society.Therefore, research must serve to increase human understanding of those resources and how best to use them for the public good

Fusion of SPOT5 multispectral and Ikonos panchromatic images

International audienceThe offer of high spectral and high spatial resolutions images has grown in the last decade. It is know possible to obtain data from different sources with different spatial and spec-tral resolutions. The field of data fusion of remotely sensed data grown also very fast in the last years. In this paper, an algorithm allowing the merging of SPOT 5 images and Ikonos images are proposed. This algorithm is based on the ARSIS concept and presents an implementation for a ratio of spatial resolution equal to 10. The ARSIS concept is first detailed. Then, the way of de-fining a new implementation based on this concept is presented, allowing to understand how to define new implementations and to develop new solutions based on this concept. The proposed algorithm is developed, describing the different steps for building a fused product from a SPOT 5 multispectral data at 10 m and from a IKONOS panchromatic data at 1 m. Some other methods are proposed. The evaluation of the quality of the different methods is achieved using a set of quantitative quality parameters. The visual quality of the products are evaluated by a set of inter-preters. Conclusions are drawn on the quality of the proposed products

Comparing alternating pressure mattresses and high-specification foam mattresses to prevent pressure ulcers in high-risk patients: the PRESSURE 2 RCT

Background: Pressure ulcers (PUs) are a burden to patients, carers and health-care providers. Specialist mattresses minimise the intensity and duration of pressure on vulnerable skin sites in at-risk patients. Primary objective: Time to developing a new PU of category ≥ 2 in patients using an alternating pressure mattress (APM) compared with a high-specification foam mattress (HSFM). Design: A multicentre, Phase III, open, prospective, planned as an adaptive double-triangular group sequential, parallel-group, randomised controlled trial with an a priori sample size of 2954 participants. Randomisation used minimisation (incorporating a random element). Setting: The trial was set in 42 secondary and community inpatient facilities in the UK. Participants: Adult inpatients with evidence of acute illness and at a high risk of PU development. Interventions and follow-up: APM or HSFM – the treatment phase lasted a maximum of 60 days; the final 30 days were post-treatment follow-up. Main outcome measures: Time to event. Results: From August 2013 to November 2016, 2029 participants were randomised to receive either APM (n = 1016) or HSFM (n = 1013). Primary end point – 30-day final follow-up: of the 2029 participants in the intention-to-treat population, 160 (7.9%) developed a new PU of category ≥ 2. There was insufficient evidence of a difference between groups for time to new PU of category ≥ 2 [Fine and Gray model HR 0.76, 95% confidence interval (CI) 0.56 to 1.04; exact p-value of 0.0890 and 2% absolute difference]. Treatment phase sensitivity analysis: 132 (6.5%) participants developed a new PU of category ≥ 2 between randomisation and end of treatment phase. There was a statistically significant difference in the treatment phase time-to-event sensitivity analysis (Fine and Gray model HR 0.66, 95% CI 0.46 to 0.93; p = 0.0176 and 2.6% absolute difference). Secondary end points – 30-day final follow-up: new PUs of category ≥ 1 developed in 350 (17.2%) participants, with no evidence of a difference between mattress groups in time to PU development, (Fine and Gray model HR 0.83, 95% CI 0.67 to 1.02; p-value = 0.0733 and absolute difference 3.1%). New PUs of category ≥ 3 developed in 32 (1.6%) participants with insufficient evidence of a difference between mattress groups in time to PU development (Fine and Gray model HR 0.81, 95% CI 0.40 to 1.62; p = 0.5530 and absolute difference 0.4%). Of the 145 pre-existing PUs of category 2, 89 (61.4%) healed – there was insufficient evidence of a difference in time to healing (Fine and Gray model HR 1.12, 95% CI 0.74 to 1.68; p = 0.6122 and absolute difference 2.9%). Health economics – the within-trial and long-term analysis showed APM to be cost-effective compared with HSFM; however, the difference in costs models are small and the quality-adjusted life-year gains are very small. There were no safety concerns. Blinded photography substudy – the reliability of central blinded review compared with clinical assessment for PUs of category ≥ 2 was ‘very good’ (kappa statistic 0.82, prevalence- and bias-adjusted kappa 0.82). Quality-of-life substudy – the Pressure Ulcer Quality of Life – Prevention (PU-QoL-P) instrument meets the established criteria for reliability, construct validity and responsiveness. Limitations: A lower than anticipated event rate. Conclusions: In acutely ill inpatients who are bedfast/chairfast and/or have a category 1 PU and/or localised skin pain, APMs confer a small treatment phase benefit that is diminished over time. Overall, the APM patient compliance, very low PU incidence rate observed and small differences between mattresses indicate the need for improved indicators for targeting of APMs and individualised decision-making. Decisions should take into account skin status, patient preferences (movement ability and rehabilitation needs) and the presence of factors that may be potentially modifiable through APM allocation, including being completely immobile, having nutritional deficits, lacking capacity and/or having altered skin/category 1 PU. Future work: Explore the relationship between mental capacity, levels of independent movement, repositioning and PU development. Explore ‘what works for whom and in what circumstances’. Trial registration: Current Controlled Trials ISRCTN01151335. Funding: This project was funded by the National Institute for Health Research Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 52. See the NIHR Journals Library website for further project information

Learning anatomy - a pain in the neck?

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Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis.

Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation of antiretroviral therapy (ART) in relation to the start of antituberculosis therapy