7,829 research outputs found

    Time course of muscle activation, energetics and mechanics of running in minimalist and traditional cushioned shoes during level running.

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    The study aimed to compare the ankle muscles activation, biomechanics and energetics of running in male runners during submaximal level run using minimalist (MinRS) and traditional cushioned (TrdRS) running shoes. During 45-min running in MinRS and TrdRS, the ankle muscles pre- and co-activation, biomechanics, and energetics of running of 16 male endurance runners (25.5 ± 3.5 yr) were assessed using surface electromyography (tibialis anterior and gastrocnemius lateralis), instrumented treadmill and indirect calorimetry, respectively. The net energy cost of running (C <sub>r</sub> ) was similar for both conditions (P = 0.25) with a significant increase over time (P < 0.0001). Step frequency (P < 0.001), and total mechanical work (P = 0.001) were significantly higher in MinRS than in TrdRS with no evolution over time (P = 0.28 and P = 0.85, respectively). The ankle muscles pre- and co-activation during the contact phase did not differ between the two shoe conditions (P ≥ 0.33) or over time (P ≥ 0.15). In conclusion, during 45-min running, Cr and muscle pre- and co-activation were not significantly different between MinRS and TrdRS with significantly higher step frequency and total mechanical work noted in the former than in the latter. Moreover, C <sub>r</sub> significantly increased during the 45-min trial in both shoe conditions along with no significant change over time in muscle activation and biomechanical variables

    Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss.

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    HER2/neu is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects. METHODS: Insulin sensitivity (minimal model) and serum HER-2 concentrations were evaluated in a cross sectional study in men (cohort 1, n = 167) and longitudinally after weight loss in obese subjects (cohort 2, n = 30). RESULTS: Serum HER-2 concentrations were positively associated with BMI and waist circumference (both r = 0.18, p = 0.02), post-load glucose (r = 0.28, p = 0.001) and fasting triglycerides (r = 0.26, p = 0.001); and negatively associated with insulin sensitivity (r = -0.29, p = 0.002, n = 109). Subjects with type 2 diabetes showed significantly increased soluble serum HER-2 concentrations. In different multivariate regression models, fasting triglycerides emerged as the factor that independently contributed to 10-11% of serum HER-2 variance.Serum HER-2 concentrations correlated significantly with fasting triglycerides and insulin sensitivity index in subjects from cohort 2. Weight loss led to a significant decrease of serum HER-2 concentrations. The change in serum HER-2 concentrations were significantly associated with the change in percent body fat and fasting triglycerides in young (below the median age of the cohort) subjects. CONCLUSIONS: Serum HER-2 concentrations might be implicated in the pathophysiology of insulin resistance and associated comorbidities

    CSA06 Computing, Software and Analysis challenge at the Spanish Tier-1 and Tier-2 sites

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    This note describes the participation of the Spanish centres PIC, CIEMAT and IFCA as Tier-1 and Tier-2 sites in the CMS CSA06 Computing, Software and Analysis challenge. A number of the facilities, services and workflows have been demonstrated at the 2008 25% scale. Very valuable experience has been gained running the complex computing system under realistic conditions at a significant scale. The focus of this note is on presenting achieved results, operational experience and lessons learnt during the challenge

    Enfermedad de Hirschsprung, a propĂłsito de un caso

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    Introduction: Hirschsprung's disease (HD) is within theclinical context one of Pediatric diseases that lowerIncidencehas, representing barely 2.7% of all of them, according todata from the American College of Pediatrics (ACP). However, its pathophysiologyand clinical behavior governed by the age of the patient are the main variablesthat complicate the diagnosis and give errors of up to 35%(ACP). The mortality of patients can amount up to 65% whenthe EH is complicated with a picture of Necrotizingenterocolitis, in a patient who has notbeen theeliminationof meconium within the first 12 hours of life must suspecteh, always takinginto account the patient's age and recallingthat preterm the same delay can be considered normal, while in the case oflarger aged patients the incidence of thedisease is lower, however the diagnostic probability should not be disregarded. Sepsis in abdominal origin andnecrotising enterocolitis are two of the major complicationsof which the physician should be prevented, even when, asreported in the present case, even patients who are opposedto the main factors of risk described in literature, such asage, can develop a HD box and a latent risk of complicationlikethe rest of patients that if shared these risk factors. Objective: To describe a case of Hirschsprung's disease. Material and methods: a descriptive, retrospective studyabout Hirschsprung's disease clinical case presenta-tion. Results: Describes a case of Hirschsprung's disease inpediatric patient with complications and resolution satisfactory quirurgica. Conclusions: The proper implementation of the clinicalmethod allows an accurate diagnosis and timely treatmentof Hirschsprung's disease.IntroducciĂłn: La Enfermedad deHirschsprung (EH) es dentro del contexto clĂ­nico-quirĂşrgico una de las patologĂ­as pediĂĄtricas que menor incidencia posee, representando a penas el 2,7% de todas ellas segĂşn datos del Colegio Americano de PediatrĂ­a (ACP). Sin embargo, su fisiopatologĂ­a y su comportamiento clĂ­nico regido por la edad del paciente son las principales variables que complican el diagnĂłstico y dan errores de hasta un 35% (ACP). La mortalidad de los pacientes puede ascender hasta un 65% cuando la EHse complica con un cuadro de enterocolitis necrotizante, en un paciente que no se ha conseguido la eliminaciĂłn de meconio dentro de las 12 primeras horas de vida deberĂĄ sospecharse de EH, siempre tomando en cuenta la edad del pacientey recordando que en pretĂŠrminos el retraso del mismopuede considerarse normal, mientras que en el caso de pacientes mĂĄs grandes de edadla incidencia de la patologĂ­a es menor, sin embargo la probabilidad diagnĂłstica no debe de ser menospreciada. La sepsis de origen abdominal y enterocolitis necrotizante son dos de las grandes complicaciones de las cuales el mĂŠdico debe estar prevenido, mĂĄs aĂşn, cuando, como se relata en el presente caso clĂ­nico, incluso pacientes que se contraponen a los principales factores de riesgo descritos por la literatura, como la edad, pueden desarrollar un cuadro de EH y tener un riesgo latente de complicaciĂłn al igual que el resto de pacientes que si comparten dichos factores de riesgos. Objetivo: Describir un caso clĂ­nico de Enfermedad de Hirschsprung. Material y mĂŠtodos: Se realizĂł un estudio descriptivo, retrospectivo, presentaciĂłn de caso clĂ­nico sobre Enfermedad de Hirschsprung. Resultados: Se describe un caso de Enfermedad de Hirschsprung en paciente pediĂĄtrico con complicaciones y resoluciĂłn quirpurgica satisfactoria. Conclusiones: La adecuada aplicaciĂłn del mĂŠtodo clĂ­nico permite un diagnĂłstico preciso y tratamiento oportuno de la Enfermedad de Hirschsprung

    Enfermedad de Hirschsprung, a propĂłsito de un caso

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    Introduction: Hirschsprung's disease (HD) is within theclinical context one of Pediatric diseases that lowerIncidencehas, representing barely 2.7% of all of them, according todata from the American College of Pediatrics (ACP). However, its pathophysiologyand clinical behavior governed by the age of the patient are the main variablesthat complicate the diagnosis and give errors of up to 35%(ACP). The mortality of patients can amount up to 65% whenthe EH is complicated with a picture of Necrotizingenterocolitis, in a patient who has notbeen theeliminationof meconium within the first 12 hours of life must suspecteh, always takinginto account the patient's age and recallingthat preterm the same delay can be considered normal, while in the case oflarger aged patients the incidence of thedisease is lower, however the diagnostic probability should not be disregarded. Sepsis in abdominal origin andnecrotising enterocolitis are two of the major complicationsof which the physician should be prevented, even when, asreported in the present case, even patients who are opposedto the main factors of risk described in literature, such asage, can develop a HD box and a latent risk of complicationlikethe rest of patients that if shared these risk factors. Objective: To describe a case of Hirschsprung's disease. Material and methods: a descriptive, retrospective studyabout Hirschsprung's disease clinical case presenta-tion. Results: Describes a case of Hirschsprung's disease inpediatric patient with complications and resolution satisfactory quirurgica. Conclusions: The proper implementation of the clinicalmethod allows an accurate diagnosis and timely treatmentof Hirschsprung's disease.IntroducciĂłn: La Enfermedad deHirschsprung (EH) es dentro del contexto clĂ­nico-quirĂşrgico una de las patologĂ­as pediĂĄtricas que menor incidencia posee, representando a penas el 2,7% de todas ellas segĂşn datos del Colegio Americano de PediatrĂ­a (ACP). Sin embargo, su fisiopatologĂ­a y su comportamiento clĂ­nico regido por la edad del paciente son las principales variables que complican el diagnĂłstico y dan errores de hasta un 35% (ACP). La mortalidad de los pacientes puede ascender hasta un 65% cuando la EHse complica con un cuadro de enterocolitis necrotizante, en un paciente que no se ha conseguido la eliminaciĂłn de meconio dentro de las 12 primeras horas de vida deberĂĄ sospecharse de EH, siempre tomando en cuenta la edad del pacientey recordando que en pretĂŠrminos el retraso del mismopuede considerarse normal, mientras que en el caso de pacientes mĂĄs grandes de edadla incidencia de la patologĂ­a es menor, sin embargo la probabilidad diagnĂłstica no debe de ser menospreciada. La sepsis de origen abdominal y enterocolitis necrotizante son dos de las grandes complicaciones de las cuales el mĂŠdico debe estar prevenido, mĂĄs aĂşn, cuando, como se relata en el presente caso clĂ­nico, incluso pacientes que se contraponen a los principales factores de riesgo descritos por la literatura, como la edad, pueden desarrollar un cuadro de EH y tener un riesgo latente de complicaciĂłn al igual que el resto de pacientes que si comparten dichos factores de riesgos. Objetivo: Describir un caso clĂ­nico de Enfermedad de Hirschsprung. Material y mĂŠtodos: Se realizĂł un estudio descriptivo, retrospectivo, presentaciĂłn de caso clĂ­nico sobre Enfermedad de Hirschsprung. Resultados: Se describe un caso de Enfermedad de Hirschsprung en paciente pediĂĄtrico con complicaciones y resoluciĂłn quirpurgica satisfactoria. Conclusiones: La adecuada aplicaciĂłn del mĂŠtodo clĂ­nico permite un diagnĂłstico preciso y tratamiento oportuno de la Enfermedad de Hirschsprung

    La participaciĂłn laboral de las mujeres: un reto para el bienestar social.

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    Este trabajo ha sido posible gracias a la cobertura de los proyectos de investigación “Riesgos y oportunidades a lo largo del curso de la vida en las sociedades postindustriales” (CICYT. Sec2003-06799), dirigido por Esping-Andersen (Universitat Pompeu Fabra) y “Nuevos Riesgos Sociales y Trayectorias de las Políticas del Bienestar” (NURSOPOB) (MEC, Plan Nacional de I+D+I), dirigidos por Luis Moreno (Unidad de Políticas Comparadas, CSIC). Agradezco a ambos el apoyo que me han prestado para poderle llevar a cabo, y de forma muy particular, a Ana Arriba y Luis Moreno, por sus comentarios y colaboración en versiones anteriores del mismo

    Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

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    A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE
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