学会抄録

video relating to fig.2(b) Originally published in Optics Express on 13 June 2016 (oe-24-12-12969

Pointing instability.avi

The video shows the pulsed 266 nm laser beam spot recorded at the focal plane of a plano-concave silica lens with 500 mm focal length. The measured laser power was 202 mW

Studies on the Selectivity Between Nickel-Catalyzed 1,2-<i>cis</i>-2-Amino Glycosylation of Hydroxyl Groups of Thioglycoside Acceptors with C(2)-Substituted Benzylidene <i>N</i>‑Phenyl Trifluoroacetimidates and Intermolecular Aglycon Transfer of the Sulfide Group

The stereoselective synthesis of saccharide thioglycosides containing 1,2-<i>cis</i>-2-amino glycosidic linkages is challenging. In addition to the difficulties associated with achieving high α-selectivity in the formation of 1,2-<i>cis</i>-2-amino glycosidic bonds, the glycosylation reaction is hampered by undesired transfer of the anomeric sulfide group from the glycosyl acceptor to the glycosyl donor. Overcoming these obstacles will pave the way for the preparation of oligosaccharides and glycoconjugates bearing the 1,2-<i>cis</i>-2-amino glycosidic linkages because the saccharide thioglycosides obtained can serve as donors for another coupling iteration. This approach streamlines selective deprotection and anomeric derivatization steps prior to the subsequent coupling event. We have developed an efficient approach for the synthesis of highly yielding and α-selective saccharide thioglycosides containing 1,2-<i>cis</i>-2-amino glycosidic bonds, via cationic nickel-catalyzed glycosylation of thioglycoside acceptors bearing the 2-trifluoromethylphenyl aglycon with <i>N</i>-phenyl trifluoroacetimidate donors. The 2-trifluoromethylphenyl group effectively blocks transfer of the anomeric sulfide group from the glycosyl acceptor to the C(2)-benzylidene donor and can be easily installed and activated. The current method also highlights the efficacy of the nickel catalyst selectively activating the C(2)-benzylidene imidate group in the presence of the anomeric sulfide group on the glycosyl acceptors

A Novel One-Pot Route for Large-Scale Synthesis of Novel Magnetic CNTs/Fe@C Hybrids and Their Applications for Binary Dye Removal

Novel magnetic CNTs/Fe@C was prepared via an easy and one-pot method with a high specific surface area (186.3 m²/g) and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectra, etc., and it was used for dye removal. Adsorption experiments showed significant differences between single and binary dye systems. The initial adsorption capacities to methylene blue (MB), methyl orange (MO), and neutral red (NR) were 132.58, 16.53, and 98.81 mg/g, and the adsorption equilibrium time was 80, 40, and 10 min, respectively. The MB-MO dye system showed a cooperative adsorption. Its adsorption capacities increased by 30% and 35%, and equilibrium time decreased by 25% and 50%, whereas the MB-NR system presented a competitive adsorption. Its adsorption capacities decreased by 20% and 33%, and its equilibrium time was elongated 2-fold. Various isotherms and kinetic models were used to fit the data and investigate the adsorption processes as well as mechanisms. Interactions between dyes in the solution and their adsorption mechanisms onto CNTs/Fe@C were also studied through Fourier transform infrared (FT-IR), Raman spectra, and zeta potential. This study indicated that CNTs/Fe@C can be used as a promising adsorbent for large-scale applications, and cooperative and competitive adsorption in binary dye systems has an influence upon the adsorption process, which can help address dye pollution efficiently

Supplementary Figures and Tables from Efficient removal of tetracycline with KOH-activated graphene from aqueous solution

Activated graphene absorbents with high specific surface area (SSA) were prepared by an easy KOH-activated method, and were applied in absorbing antibiotics, such as tetracycline (TC). After activation, many micropores were introduced to graphene oxide sheets, leading to higher SSA and many new oxygen-containing functional groups, which gave KOH-activated graphene excellent adsorption capacity (approx. 532.59 mg g⁻¹) of TC. Further study on the adsorption mechanism showed that the Langmuir isotherm model and the pseudo-second-order kinetic model fitted with experiment data. To further understand the adsorption process, the effects of solid–liquid ratio, pH, ionic strength and coexisting ions were also investigated. The results revealed that, compared with pH and ionic strength, solid–liquid ratio and coexisting ions (Cu²⁺, CrO₄²⁻) had more significant influence over the adsorption performance. The findings provide guidance for application of KOH-activated graphene as a promising alternative adsorbent for antibiotics removal from aqueous solutions

Visualization 5: Experimental study of low-loss single-mode performance in anti-resonant hollow-core fibers

video referred in the manuscript above fig.2 Originally published in Optics Express on 13 June 2016 (oe-24-12-12969

Scalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and T_N Antigen via Nickel Catalysis

The highly α-selective and scalable synthesis of the Fmoc-protected GalNAc-threonine amino acid and T_N antigen in gram scale (0.5–1 g) is described. The challenging 1,2-<i>cis</i>-2-amino glycosidic bond is addressed through a coupling of threonine residues with C(2)-<i>N</i>-<i>ortho</i>-(trifluoro­methyl)­benzyliden­amino trihaloacetimidate donors mediated by Ni­(4-F-PhCN)₄(OTf)₂. The desired 1,2-<i>cis</i>-2-amino glycoside was obtained in 66% yield (3.77 g) with α-only selectivity and subsequently transformed into the Fmoc-protected GalNAc-threonine and T_N antigen. This operationally simple procedure no longer requires utilization of the commonly used C(2)-azido donors and overcomes many of the limitations associated with the synthesis of 1,2-<i>cis</i> linkage

Additional file 1: Figure S1. of Disruption of clathrin-dependent trafficking results in the failure of grass carp reovirus cellular entry

Cell viability was assessed using a Muse Count and Viability Kit to determine the safety of applied inhibitors. (PPT 917 kb

Downregulation of splicing regulator RBFOX1 compromises visual depth perception

<div><p>Rbfox1 is a splicing regulator that has been associated with various neurological conditions such as autism spectrum disorder, mental retardation, epilepsy, attention-deficit/hyperactivity disorder and schizophrenia. We show that in adult rodent retinas, Rbfox1 is expressed in all types of retinal ganglion cells (RGCs) and in certain subsets of amacrine cells (ACs), within the inner nuclear (INL) and ganglion cell (GCL) layers. In the INL, all Rbfox1-positive cells were colocalized with GABAergic ACs, however not all GABAergic ACs were immunostained for Rbfox1. In the GCL, a vast majority of GABAergic dACs were Rbfox1-immunopositive. Furthermore, all cholinergic starburst ACs (SACs) in the INL (type a) and in the GCL (type b) were Rbfox1 positive. The expression of Rbfox1 in the retina significantly overlapped with expression of Rbfox2, another member of Rbfox family of proteins. Rbfox2, in addition to RGCs and ACs, was also expressed in horizontal cells. In developing retinas at E12 and E15, Rbfox1 is localized to the cytoplasm of differentiating RGCs and ACs. Between P0 and P5, Rbfox1 subcellular localization switched from cytoplasmic to predominantly nuclear. Downregulation of <i>Rbfox1</i> in adult <i>Rbfox1</i>^loxP/loxP mice had no detectable effect on retinal gross morphology. However, the visual cliff test revealed marked abnormalities of depth perception of these animals. RNA sequencing of retinal transcriptomes of control and <i>Rbfox1</i> knockout animals identified a number of Rbfox1-regulated genes that are involved in establishing neuronal circuits and synaptic transmission, including Vamp1, Vamp2, Snap25, Trak2, and Slc1A7, suggesting the role of Rbfox1 in facilitating synaptic communications between ACs and RGCs.</p></div

Flower phenotypes of <i>NGAL1</i> OE lines.

<p>A. Floral tissues of wild type and <i>NGAL1</i> OE plants. Note the conspicuous absence of the flower petals in <i>NGAL1</i> OE lines. B–E. Individual flower phenotypes of wild type and <i>NGAL1</i> OE plants. Individual flowers from wild type (B), two <i>NGAL1</i> OE lines, OE-2 (C and E) and OE-3 (D), were shown. Note the filamentous structure found in some flowers from OE lines (pointed by the white arrow head).</p