Additional file 4: Table S4. of Transcriptomic analysis reveals the key immune-related signalling pathways of Sebastiscus marmoratus in response to infection with the parasitic ciliate Cryptocaryon irritans

Immune systems with differentially expressed genes between C. irritans-infected (B, C, D, E) and non-infected (A) S. marmoratus. (DOCX 133 kb

Additional file 3: Table S3. of Transcriptome analysis of dormant tomonts of the marine fish ectoparasitic ciliate Cryptocaryon irritans under low temperature

KEGG pathway enrichment analysis of the differently expressed genes among low temperature treated (B) and untreated (A, C) C. irritans tomonts. (XLSX 16 kb

Supplementary_materials - De Novo KCNQ2 Mutation in One Case of Epilepsy of Infancy With Migrating Focal Seizures That Evolved to Infantile Spasms

<p>Supplementary_materials for De Novo KCNQ2 Mutation in One Case of Epilepsy of Infancy With Migrating Focal Seizures That Evolved to Infantile Spasms by Haolin Duan, Jing Peng, Miriam Kessi, and Fei Yin in Child Neurology Open</p

Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients

<div><p>Proofreading deficiencies of hepatitis B virus polymerase result in frequent DNA mutations in the hepatitis B virus genome. Here, we performed sequencing analysis of the hepatitis B virus polymerase gene to assess its association with the postoperative survival in 92 patients with HBV-related hepatocellular carcinoma by using the Kaplan–Meier method. The 2525, 2733, 2738, 2768, 2946, 3063, 3066, 3109, 31, 529, 735, 939, 1078, 1137, 1383, 1461, 1485, 1544, and 1613 mutation sites were identified as being associated with HCC outcomes by the log-rank test. After adjusting for clinical characteristics by using the Cox hazard model, site 31 (relative risk, 8.929; 95% confidence interval, 3.433–23.22; <i>P</i> = 0.000) in the spacer domain and sites 529 (relative risk, 5.656; 95% confidence interval, 1.599–19.999; <i>P</i> = 0.007) and 1078 (relative risk, 3.442; 95% confidence interval, 1.070–11.068; <i>P</i> = 0.038) in the reverse transcriptase domain of hepatitis B virus polymerase were identified as independent predictors of postoperative survival in hepatitis B virus related hepatocellular carcinoma. The mutations at the 31 (Ser314Pro), 529 (Asp480Asn), and 1078 (Ser663Ala) sites all resulted in amino acid changes in hepatitis B virus polymerase and were associated with shortened life-span. The 31 and 529 sites were located in the overlapping region for the PreS and S genes but did not induce amino acid substitution in these two regions. Our finding of the correlation between hepatitis B virus DNA polymerase mutations and hepatocellular carcinoma survival will help identify the patients subgroup with poor prognosis, and help the clinicians to refine the therapeutic decision individualized.</p></div

Incidence of measles in Henan in May 2009 and clusters detected with default (a) and selected maximum spatial cluster size using MCS-P (b).

<p>Administrative codes of 42 clustering counties are labeled. RR of each counties are presented as bar.</p

Univariate analysis of HBV polymerase gene mutations associated with postoperative survival in patients with HBV-HCC.

<p>Univariate analysis of HBV polymerase gene mutations associated with postoperative survival in patients with HBV-HCC.</p

Online marketing of a chosen company

The main goal of this thesis was evaluate the impact of indiviudal tools of communication mix on the results of the online campaign of the chosen brand. This campaign lasted for almost three months. The core of the campaign was consumer competition. The main goal of this campaign was sale increase and brand awareness. In the first part, I dealt with the tools of the communication mix from the point of view of the use in marketing and measuring their performance. In the second part, I analyzed the way brand worked with individual tools of commuciation mix and then I evaluated the tools according to established criteria such as impresion, interaction, web traffic and conversions. I used analytical tools to evaluate the success of each of the communication mix tools. After evaluating the communication mix tools, I suggested recommendations for further brand communication on the Internet. The biggest impact on the results of the campaign had Facebook, which clearly dominated among all of the tools from the point of view of all the criteria

Schema of the polymerase region and overlapping preS, S, and X regions.

<p>Schema of the polymerase region and overlapping preS, S, and X regions.</p

Average performance measures for different maximum spatial cluster sizes in 600-two-1.

<p>Average performance measures for different maximum spatial cluster sizes in 600-two-1.</p

Distribution of mutation frequency in the HBV polymerase region.

<p>The square indicates the mutations associated with survival in HBV-HCC, as determined by univariate analysis using the log-rank test; the rhombus indicates mutations that are not associated with HBV-HCC.</p