Additional file 1: of The management strategies of cancer-associated anorexia: a critical appraisal of systematic reviews

Search method. (DOCX 14 kb

Image_2_A PD-L1 Negative Advanced Gastric Cancer Patient With a Long Response to PD-1 Blockade After Failure of Systematic Treatment: A Case Report.pdf

BackgroundIt was widely accepted that programmed death-ligand 1 (PD-L1) positive, tumor mutational burden-high (TMB-H) or microsatellite instability-high (MSI-H) tumor are prone to have better treatment response to immune checkpoint blockade. The value of immune checkpoint blockade in PD-L1 negative gastric cancer patients has been questioned due to lower objective response rate (ORR).Case PresentationWe report an unusual case of a PD-L1 negative, proficient mismatch repair (pMMR)/microsatellite stability (MSS), tumor mutational burden-low (TMB-L) gastric cancer patient who achieved good response to immune checkpoint blockade after failure of systematic treatment. Multiple lymph nodes and bone metastases are the main characteristics of this patient. The patient survived for more than 30 months after diagnosis.ConclusionsThis case suggested that PD-L1 negative gastric cancer patient may also benefit from immune checkpoint blockade. In gastric cancer, patients with lymph node metastasis may be potential beneficiaries.</p

MOESM2 of A technical appraisal of guidelines for the management of skin rash in patients on chemotherapy and targeted therapy

Additional file 2. Internet list

Interaction effects between irrigation rates, sand content (0–15 cm), and slope on cotton yield in a 72-ha field in Hale County, Texas in 2017.

Interaction effects between irrigation rates, sand content (0–15 cm), and slope on cotton yield in a 72-ha field in Hale County, Texas in 2017.</p

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Soil texture and EC_a variability for two fields within a 194-ha farm in Hale County, Texas.

Soil texture and ECa variability for two fields within a 194-ha farm in Hale County, Texas.</p

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Linear mixed-effects model for predicting cotton lint yield using irrigation rates, soil properties, and topography in two fields within a 194-ha farm in Hale County, Texas in 2017.

Linear mixed-effects model for predicting cotton lint yield using irrigation rates, soil properties, and topography in two fields within a 194-ha farm in Hale County, Texas in 2017.</p

Study site with irrigation treatment design in two fields of a 194-ha farm in Hale County, Texas in 2017 (basemap source: Esri, DigitalGlobe, GeoEye, i-cubed, USDA FSA, USGS, AEX, Getmapping, Aerogrid, IGN, IGP, swisstopo, and the GIS User Community).

Study site with irrigation treatment design in two fields of a 194-ha farm in Hale County, Texas in 2017 (basemap source: Esri, DigitalGlobe, GeoEye, i-cubed, USDA FSA, USGS, AEX, Getmapping, Aerogrid, IGN, IGP, swisstopo, and the GIS User Community).</p