Characterization of the Nigerian Shoreline using Publicly-Available Satellite Imagery

Current methods of shoreline mapping include aerial and high-resolution satellite imagery and ground-based surveying, all of which require considerable investment of human and material resources. Mapping and continuous updating of the shoreline for developing countries, such as Nigeria, is a challenge. Most of the information on the Nigerian shoreline is based on ‘surveys of opportunity’ performed by various government agencies over a wide time span. Additional surveys conducted by the multi-national oil and gas companies exploring in the region are typically not available for use by government agencies. In cases where the data are available, the variety in methods used for shoreline mapping can result in inconsistencies

Develping a Methodology for the Mapping and Characterization of the Nigerian Coastline Using Remote Sensing

Coastline delineation is important in maritime boundary determination, as well as for analyzing coastline change rates due to coastal erosion, sea level change, storms, and other causes. Coastline change rate estimates depend on the uncertainty of the current and historical coastlines used in the analysis, which, in turn, depend on the surveying technologies and techniques that were originally used. Current techniques for coastline mapping include photogrammetric delineation using tide-coordinated aerial imagery. However, in many developing countries, the charted coastlines may have been inadequately and inconsistently mapped largely due to inadequate resources. This paper describes the use of an automated technique for coastline mapping and classification that is based on satellite imagery. A spectral analysis using different image bands can be used to define the land/water boundary and characterize the coastal area around the coastline. A first-order uncertainty analysis was also performed. The satellite-derived coastlines were compared to charted coastlines to evaluate the adequacy and consistency of the charted coastlines. The satellite-derived coastlines were also compared to coastlines derived from historical maps to assess changes and change rates. The results of the coastline uncertainty analysis were then used to compute propagated uncertainties in coastline change rate estimates and to gain greater insight into actual changes. The procedure was developed in a GIS environment using study sites along the Nigerian coastline. However, this procedure can be applied to other poorly charted/mapped coastal areas as well

Spectral characterization of the Nigerian shoreline using Landsat imagery

The challenges of shoreline mapping include the high costs of acquiring up-to-date survey data over the coastal area. As a result, in many developing countries, the shoreline has not been consistently mapped. The variety of methods used for this mapping and the large time differences between the surveys (on the order of decades) could result in inaccuracies in shoreline data. This study presents the development of a shoreline characterization procedure for the Nigerian coastline using satellite remote sensing technology. The study goal is to produce a complete, consistent and continuous shoreline map using publicly available data processed in a GIS environment. A spectral analysis using different satellite bands was conducted to define the land/water boundary and characterize the coastal area around the shoreline. The satellite-derived shorelines were compared to charted shorelines for adequacy and consistency. The procedure was developed based on study sites along the Nigerian coastline. Although the shoreline characterization procedure is developed based on datasets from Nigeria, the procedure should be suitable for use in mapping other developing areas around world

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

Abstract Background Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding anti-diabetic activity of the seeds. Methods A comprehensive literature search on articles published on phytochemical analysis and various pharmacological activities of Hunteria umbellate was carried out using search engines such as Google Scholar, PubMed and Science Direct. Results In this review, it was deduced that H. umbellate is employed in folk medicine as an elixir for obesity, fever, leprosy sores, menstrual pain, infertility, yaws, intestinal worms, abdominal discomfort and stomach ache. Due to their durability and immunity against termites, the stems are coveted and desired as timbers in the construction of houses, while the bark has been reportedly exported to Europe for medicinal uses. Pharmacological activities such as fertility enhancing, aphrodisiac, hypoglycemic, anti-inflammatory, has been ascribed to the different morphological organs of H. umbellate. Moreover, compounds belonging to important classes of secondary metabolites with biological activities such as triterpenoids, flavonoids, tannins, alkaloids, quinic acids have been identified and characterized from the plant. Conclusion From this review, it can be inferred that, numerous and bioactive principles with known biological usefulness are present in the extracts of H. umbellate and might be responsible for the observed biological and pharmacological activities

Computational prediction of nimbanal as potential antagonist of respiratory syndrome coronavirus

The high pathogenic nature of the Middle East Respiratory coronavirus (MER) and the associated high fatality rate demands an urgent attention from researchers. Because there is currently no approved drug for the management of the disease, research efforts have been intensified towards the discovery of a potent drug for the treatment of the disease. Papain Like protease (PLpro) is one of the key proteins involved in the viral replication. We therefore docked forty-six compounds already characterized from Azadirachta indica, Xylopia aethipica and Allium cepa against MERS-CoV-PLpro.The molecular docking analysis was performed with AutoDock 1.5.6 and compounds which exhibit more negative free energy of binding, and low inhibition constant (Ki) with the protein (MERS-CoV-PLpro) were considered potent. The physicochemical and pharmacokinetic properties of the compounds were predicted using the Swissadme web server.Twenty-two of the compounds showed inhibition potential similar to dexamethasone and remdesvir, which had binding affinity of −6.8 and −6.3 kcal/mol respectively. The binding affinity of the compounds ranged between −3.4 kcal/mol and −7.7 kcal/mol whereas; hydroxychloroquine had a binding affinity of −4.5 kcal/mol. Among all the compounds, nimbanal and verbenone showed drug likeliness, they did not violate the Lipinski rule neither were they inhibitors of drug-metabolizing enzymes. Both nimbanal and verbenone were further post-scored with MM/GBSA and the binding free energy of nimbanal (−25.51 kcal/mol) was comparable to that of dexamethasone (−25.46 kcal/mol). The RMSD, RMSF, torsional angle, and other analysis following simulation further substantiate the efficacy of nimbanal as an effective drug candidate. In conclusion, our study showed that nimbanal is a more promising therapeutic agent and could be a lead for the discovery of a new drug that may be useful in the management of severe respiratory coronavirus syndrome

Potential inhibitory properties of structurally modified quercetin/isohamnetin glucosides against SARS-CoV-2 Mpro; molecular docking and dynamics simulation strategies

Concerned organizations and individuals are fully engaged in seeking appropriate measures towards managing Severe Acute Respiratory Syndrome Coronavirus 2 (SAR-CoV-2) infection because of the unprecedented economic and health impact. SAR-CoV-2 Main protease (SARS-CoV-2 Mpro) is unique to the survival and viability of the virus. Therefore, inhibition of Mpro can block the viral propagation.Thirty (30) derivatives were built by changing the glucosides in the Meta and para position of quercetin and isohamnetin. Molecular docking analysis was used for the screening of the compounds. Dynamics simulation was performed to assess the stability of the best pose docked complex. Molecular mechanics binding free energy calculation was done by Molecular Mechanics/Poisson-Boltzmann Surface Area (MMPBSA).Overall analysis showed that the compounds are allosteric inhibitors of SARS-CoV-2 Mpro. Dynamic simulation analysis established the stability of Mpro-ISM-1, Mpro-ISD-3, Mpro-IST-2, Mpro-QM-2, and Mpro-QD-6 complexes with a maximum of 7 hydrogen bonds involved in their interaction. The MMPBSA binding free energies for ISM-1, ISD-3, IST-2, QM-2, and QD-6 were −92.47 ± 9.06, −222.27 ± 32.5, 180.72 ± 47.92, 156.46 ± 49.88 and −93.52 ± 48.75 kcal/mol respectively. All the compounds showed good pharmacokinetic properties, while only ISM-1 inhibits hERG and might be cardio-toxic.Observations in this study established that the glucoside position indeed influenced the affinity for SARS-CoV-2 Mpro. The study also suggested the potentials of ISD-3, QM-2 and QD-6 as potent inhibitors of the main protease, further experimental and clinical studies are however necessary to validate and establish the need for further drug development processes. Therefore, future studies will be on the chemical synthesis of the compounds and investigation of the in-vitro inhibition of SARS-CoV-2