CCD-based imaging and 3D space--time mapping of terahertz fields via Kerr frequency conversion

We investigate the spatially and temporally resolved four-wave mixing of terahertz (THz) fields and optical pulses in large-bandgap dielectrics, such as diamond. We show that it is possible to perform beam profiling and space–time resolved mapping of THz fields by encoding the spatial information into an optical signal, which can then be recorded by a standard CCD camera

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

International Impact of COVID-19 on the Diagnosis of Heart Disease

BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery of diagnostic care for cardiovascular disease, which remains the leading cause of death worldwide, have not been quantified.OBJECTIVES The study sought to assess COVID-19`s impact on global cardiovascular diagnostic procedural volumes and safety practices.METHODS The International Atomic Energy Agency conducted a worldwide survey assessing alterations in cardiovascular procedure volumes and safety practices resulting from COVID-19. Noninvasive and invasive cardiac testing volumes were obtained from participating sites for March and April 2020 and compared with those from March 2019. Availability of personal protective equipment and pandemic-related testing practice changes were ascertained.RESULTS Surveys were submitted from 909 inpatient and outpatient centers performing cardiac diagnostic procedures, in 108 countries. Procedure volumes decreased 42% from March 2019 to March 2020, and 64% from March 2019 to April 2020. Transthoradc echocardiography decreased by 59%, transesophageat echocardiography 76%, and stress tests 78%, which varied between stress modalities. Coronary angiography (invasive or computed tomography) decreased 55% (p < 0.001 for each procedure). hi multivariable regression, significantly greater reduction in procedures occurred for centers in countries with lower gross domestic product. Location in a low-income and lower-middle-income country was associated with an additional 22% reduction in cardiac procedures and less availability of personal protective equipment and teteheatth.CONCLUSIONS COVID-19 was associated with a significant and abrupt reduction in cardiovascular diagnostic testing across the globe, especially affecting the world's economically challenged. Further study of cardiovascular outcomes and COVID-19-related changes in care delivery is warranted. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Desiring To Be a Non-Birth Mother. Lesbian Women Narrating non Bio-Normative Maternal Identity in Italy

Over the past three decades, Western societies have witnessed transformations in lesbian motherhood. This study examines the emergence of de novo lesbian families in Italy, focusing on nonbirth lesbian mothers (NBLMs). It addresses a gap in existing literature by exploring how NBLMs construct their sense of self as mothers, moving beyond the focus on decision-making processes within lesbian couples planning parenthood. The research is situated within the Italian context, where parenting remains influenced by heteronormativity and monomaternalism. Using a qualitative approach, the study analyses retrospective narratives of 13 Italian NBLMs in lesbian families. It examines how these women articulate the emergence of maternal desire and anchor their self-definition as mothers, detaching motherhood from its biological roots. The study identifies a narrative structure situating these accounts along a continuum, from rejections of normative maternity to strategic adoptions of traditional family codes. Participants navigate between these poles, engaging in a dialectic that intertwines counter-narratives on motherhood with processes of norm re-appropriation. The findings illuminate the normalization of unconventional routes to maternity, and reveal metamorphoses of parenting paradigms and resistance to hegemonic motherhood narratives. Results contribute to nuanced comprehensions of contemporary familial configurations and foster pluralistic understandings of experiences within the maternal category

Throughput maximization and buffer design of robotized flexible production systems with feeder renewals and priority rules

Automation is a powerful way to reduce production costs. The growing market demand for a wide set of models and small batch production make flexible automated production systems an emerging need in several industries. The aim of this paper is to analyze and to maximize the performance of robotized flexible production systems consisting of a robot, feeder, working station, and unloading station, where the operations of the working cycle are scheduled using a sequencing algorithm based on priority rules. Since the working cycle is not predefined, the cycle time is strongly influenced by the parameters characterizing the workcell such as the workcell layout, the robot transfer movements, the feeder, the working operations, and the presence of a buffer between stations. In this work, we modeled the working cycle of a simple but representative layout of an industrial robotized flexible production system with and without buffer, and we implemented a recursive algorithm to estimate the cycle time. The analytical model derived was compared to the experimental results, obtained by using a prototype of the flexible production workcell. The results show that the analytical model is a powerful tool to estimate the performance of the workcell and to identify the design variables or their combinations that maximize the throughput

Hybrid Flexible Assembly Systems (H-FAS): Bridging the gap between traditional and fully flexible assembly systems

none4noAutomation can be a valid way to reduce production costs. Considering medium/low volumes and a wide set of different models, a mixed model assembly work cell is a proper automated production system. The authors have recently introduced a new class of flexible assembly systems (FAS), the F-FAS, in which highly flexible feeding systems are used to improve the flexibility and reduce the set-up times at batch change. Such systems, guaranteeing a higher level of flexibility than traditional automated FAS, show some limitations in terms of productivity, due to the stochastic process of feeding and reorientation of parts and to the time spent for image acquisition and processing. The aim of this paper is to introduce an innovative automated assembly work cell, called the hybrid flexible assembly system (H-FAS), that merges the traditional FAS bowl feeder utilisation with the innovative F-FAS feeding concepts. The paper analyses the main factors influencing the H-FAS design, productivity and cost. Moreover, through a comparative analysis between the different single cell assembly systems, it defines the working conditions in which they can be preferable.restrictedGiulio Rosati; Maurizio Faccio; Luca Barbazza; Aldo RossiRosati, Giulio; Faccio, Maurizio; Barbazza, Luca; Rossi, Ald