6 research outputs found
CAZADORES RECOLECTORES DE LA BOCA DEL ESTUARIO DEL RĂŤO GALLEGOS, SANTA CRUZ, ARGENTINA HUNTER GATHERERS AT THE RĂŤO GALLEGOS ESTUARY MOUTH, SANTA CRUZ, ARGENTINA
Se caracterizan las poblaciones de cazadores recolectores que habitaron el sur del estuario rĂo Gallegos, cuenca hĂdrica más austral de Patagonia continental argentina. Se acota cronolĂłgicamente parte del espacio utilizado mediante el fechado de suelos, relaciones geomorfolĂłgicas y el análisis de los conjuntos lĂticos. Se evalĂşa el papel del estuario como concentrador de mayor actividad humana en comparaciĂłn con espacios relativamente alejados del ámbito costero. Se concluye que el sector costero habrĂa tenido un uso más intensivo que el resto del valle del rĂo Gallegos y que a su vez, la costa del estuario fue ocupada más recurrentemente que el litoral atlántico. Estas ocupaciones pueden ser atribuidas a la parte final del Holoceno tardĂo.This contribution describes the populations of hunter-gatherer that inhabited the southern portion of the RĂo Gallegos estuary, the southernmost river basin of Argentinean continental Patagonia. Soil dating, geomorphological relationships, and the study of lithic assemblages are used to narrow down chronologically the use of space. The role of the estuary as a concentrator of human activity is evaluated by comparison to relatively distant upland spaces. We conclude that the coastal environment would have been used more intensively and recurrently than both the region upstream the Gallegos river and the neighbouring Atlantic coast. These occupations can be assigned to the terminal late Holocene
Simposio "Paisajes arqueolĂłgicos en circuitos turĂsticos no convencionales"
Los trabajos acadĂ©micos que aquĂ se reĂşnen son resultado de un simposio denominado “Paisajes arqueolĂłgicos en circuitos turĂsticos no convencionales” llevado a cabo, en julio del 2009, en el marco del 53o Congreso Internacional de Americanistas realizado en la ciudad de MĂ©xico D.F. La propuesta de este encuentro se desprende como una actividad programada por el proyecto de investigaciĂłn denominado “LĂnea de base arqueolĂłgica en la cuenca del rĂo Gallegos: su importancia para el desarrollo de un turismo sustentable” (29/A188), del cual somos responsables. Dicho proyecto contempla un área de demanda regional como es la gestiĂłn y la protecciĂłn del Patrimonio Cultural.
Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis
Background: Brown propolis is the major type of propolis found in Cuba; its principal component is nemorosone, the major constituent of Clusia rosea floral resins. Nemorosone has received increasing attention due to its strong in vitro anti-cancer action. The citotoxicity of nemorosone in several human cancer cell lines has been reported and correlated to the direct action it has on the estrogen receptor (ER). Breast cancer can be treated with agents that target estrogen-mediated signaling, such as antiestrogens. Phytoestrogen can mimic or modulate the actions of endogenous estrogens and the treatment of breast cancer with phytoestrogens may be a valid strategy, since they have shown anti-cancer activity.Methods: The aim of the present investigation was to assess the capacity of nemorosone to interact with ERs, by Recombinant Yeast Assay (RYA) and E-screen assays, and to determine by comet assay, if the compound causes DNA-damaging in tumoral and non-tumoral breast cells.Results: Nemorosone did not present estrogenic activity, however, it inhibited the 17-β-estradiol (E2) action when either of both methods was used, showing their antiestrogenicity. The DNA damage induced by the benzophenone in cancer and normal breast cells presented negative results.Conclusion: These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of the interaction between microglial/astrocytes cells and GB may constitute a potential therapeutic target to overcome tumor malignancy. In the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes-GB interactions, which is particularly the alterations that occur in the cell's extracellular matrix and the cytoskeleton. We overview the cytokines, chemokines, neurotrophic, morphogenic, metabolic factors, and non-coding RNAs actions crucial to these interactions. We have also discussed the most recent studies regarding the mechanisms of transportation and communication between microglial/astrocytes - GB cells, namely through the ABC transporters or by extracellular vesicles. Lastly, we highlight the therapeutic challenges and improvements regarding the crosstalk between these glial cells and GB