1,707 research outputs found

    Mouse Models of Allergic Diseases: TSLP and Its Functional Roles

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    ABSTRACTThe cytokine TSLP was originally identified in a murine thymic stromal cell line as a lymphoid growth factor. After the discovery of TSLP, extensive molecular genetic analyses and gene targeting experiments have demonstrated that TSLP plays an essential role in allergic diseases. In this review, we discuss the current status of TSLP and its functional role in allergic diseases particularly by focusing on effects of TSLP on haematopoietic cells in mouse models. It is our conclusion that a number of research areas, i.e., a new source of TSLP, effects of TSLP on non-haematopoietic and haematopoietic cells, synergistic interactions of cytokines including IL-25 and IL-33 and a regulation of TSLP expression and its function, are critically needed to understand the whole picture of TSLP involvement in allergic diseases. The mouse models will thus contribute further to our understanding of TSLP involvement in allergic diseases and development of therapeutic measures for human allergic diseases

    On the influence of time and space correlations on the next earthquake magnitude

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    A crucial point in the debate on feasibility of earthquake prediction is the dependence of an earthquake magnitude from past seismicity. Indeed, whilst clustering in time and space is widely accepted, much more questionable is the existence of magnitude correlations. The standard approach generally assumes that magnitudes are independent and therefore in principle unpredictable. Here we show the existence of clustering in magnitude: earthquakes occur with higher probability close in time, space and magnitude to previous events. More precisely, the next earthquake tends to have a magnitude similar but smaller than the previous one. A dynamical scaling relation between magnitude, time and space distances reproduces the complex pattern of magnitude, spatial and temporal correlations observed in experimental seismic catalogs.Comment: 4 Figure

    Note on the Form of Japanese Castle Walls

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    Vibrations of a Railway Bridge Pier

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